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Medicina
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Burn Injuries: From Intensive Care to Rehabilitation—Multidisciplinary Approaches to Optimizing...
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Burn Injuries: From Intensive Care to Rehabilitation—Multidisciplinary Approaches to Optimizing Survival, Function, and Quality of Life

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Intensive Care/ Anesthesiology".

Deadline for manuscript submissions: 1 July 2026 | Viewed by 896

Special Issue Editors

Prof. Dr. Leila Harhaus-Wähner

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Guest Editor
Department of Hand, Replantation, and Microsurgery, BG Trauma Center Berlin, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
Interests: plastic and reconstructive surgery; reconstructive surgery; nerve regeneration
Dr. Martin Aman

E-Mail Website
Guest Editor
Department of Hand, Replantation, and Microsurgery, BG Trauma Center Berlin, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
Interests: plastic and reconstructive surgery; reconstructive surgery; nerve regeneration
Dr. Felix Klimitz

E-Mail Website
Guest Editor
Division of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, CT, USA
Interests: burns; plastic and reconstructive surgery; hand surgery

Special Issue Information

Dear Colleagues,

Over the decades, advances in resuscitation protocols, critical care, and surgical reconstruction have markedly improved survival after severe burn injuries. As mortality declines, there is increasing recognition of the long-term consequences of burn trauma and the need for coordinated, burn-specific rehabilitation to ensure that survivors regain independence, psychological well-being, and social participation. This Special Issue, “Burn Injuries: From Intensive Care to Rehabilitation—Multidisciplinary Approaches to Optimizing Survival, Function, and Quality of Life”, will highlight multidisciplinary approaches spanning from acute resuscitation, surgical, and intensive care to inpatient and community-based rehabilitation. A particular emphasis will be placed on comprehensive burn rehabilitation programs grounded in the International Classification of Functioning, Disability and Health (ICF) framework that integrate the physical, psychological, and social dimensions of recovery. We welcome original research, clinical trials, and reviews addressing innovations in critical care, reconstructive surgery, scar management, pain and mental health interventions, and outcome measurement in burn rehabilitation. Together, these contributions will contribute to a holistic understanding of recovery after burn injuries that extends beyond survival toward full reintegration and long-term well-being.

Prof. Dr. Leila Harhaus-Wähner
Dr. Martin Aman
Dr. Felix Klimitz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • burn injury
  • intensive care
  • multidisciplinary rehabilitation
  • quality of life
  • functional recovery
  • psychological outcomes
  • return to work

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Published Papers (1 paper)

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Research

14 pages, 1368 KB  
Article
Detection of Liver Dysfunction in Severe Burn Injury with Bedside Measurement of Perfusion
by Marianne Kruse, András Varga, Berthold Hoppe, Alexander Hoenning, Martin Aman, Klaus Hahnenkamp, Marc Dominik Schmittner and Volker Gebhardt
Medicina 2026, 62(3), 466; https://doi.org/10.3390/medicina62030466 - 28 Feb 2026
Viewed by 605
Abstract
Background and Objectives: Severe burn injuries are still associated with high mortality. The length of intensive care stay is strongly influenced by the severity of organ failure, with multi-organ failure being the main cause of death in up to 40% of cases. [...] Read more.
Background and Objectives: Severe burn injuries are still associated with high mortality. The length of intensive care stay is strongly influenced by the severity of organ failure, with multi-organ failure being the main cause of death in up to 40% of cases. Liver dysfunction is the second most common organ failure. Conventional diagnosis relies on static laboratory parameters that reflect damage already caused. Measuring the hepatic clearance of indocyanine green (LiMON®) offers a dynamic, bedside method for detecting liver dysfunction early, enabling timely therapy adjustments. Materials and Methods: In this prospective single-centre observational study, all patients admitted to the Unfallkrankenhaus Berlin Burns Centre from October 2022 to September 2024 with ≥30% TBSA burns were included. Liver function was assessed via LiMON® within 24 h post-injury and every 48 h until day 14 or ICU discharge. Static liver parameters were measured in parallel. Results: We included a total of 23 patients. An initial measurement was only successful in 18 cases. On admission, six patients (33%) had normal liver function with a plasma duration rate (PDR) > 18% (PDR 30.9 ± 7.3%), while 12 (67%) showed reduced clearance (PDR 14.5 ± 2.6%). In 75% of cases (n = 9), function recovered within 48 h. Based on PDR progression, four liver function patterns were defined: “stable”, “recovery”, “late insufficiency”, and “failure”; a fifth pattern included all patients who were deceased during this study (“death”). These groups differed in fluid therapy, plasma transfusion, and catecholamines administered. PDR correlated well with aminotransferase levels. Conclusions: Dynamic liver function monitoring enables earlier detection of impairment than static markers. Early identification of at-risk patients could guide fluid management and improve outcomes. LiMON® is a valuable tool in burn care, though alternative methods may be needed in patients with severe systemic hypoperfusion. Full article
(This article belongs to the Special Issue Burn Injuries: From Intensive Care to Rehabilitation—Multidisciplinary Approaches to Optimizing Survival, Function, and Quality of Life)
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