Venous Thromboembolism: Diagnosis, Management, and Treatment

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Hematology and Immunology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 846

Special Issue Editors


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Guest Editor
Unit of Internal Medicine, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95123 Catania, Italy
Interests: vascular disease; venous thromboembolism; superficial vein thrombosis

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Guest Editor
Unit of Angiology, Cardio-Thoraco-Vascular Department, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95123 Catania, Italy
Interests: vascular disease; venous thromboembolism; superficial vein thrombosis; vascular ultrasound
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Special Issue Information

Dear Colleagues,

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a common and serious clinical condition and a leading cause of preventable morbidity and mortality worldwide. Since Virchow’s early description of the mechanisms of thrombosis, important progress has been made in understanding VTE as a multifactorial disease driven by genetic predisposition, acquired risk factors, and alterations in coagulation and vascular biology. Despite these advances, VTE remains frequently underdiagnosed and is associated with significant acute and long-term complications.

The primary aim of this Special Issue is to provide a rigorous and comprehensive overview of contemporary approaches to the diagnosis, management, and treatment of VTE. This collection seeks to critically appraise current evidence, address ongoing controversies, and highlight areas requiring further investigation by integrating insights from basic, translational, and clinical research.

This Special Issue places particular emphasis on cutting-edge research, including advances in diagnostic algorithms, imaging modalities, biomarkers, and risk stratification strategies, as well as evolving anticoagulant therapies and interventional techniques. Emerging concepts such as immunothrombosis, personalized thromboprophylaxis, and the application of real-world data and artificial intelligence are also within its scope.

We invite submissions of original research articles, systematic and narrative reviews, meta-analyses, and consensus or position papers addressing all aspects of VTE. Contributions focusing on special populations, real-world clinical practice, long-term outcomes, and innovative methodological approaches are particularly encouraged.

Dr. Marco Mangiafico
Dr. Luca Costanzo
Guest Editors

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Keywords

  • venous thromboembolism
  • pulmonary embolism
  • superficial vein thrombosis
  • deep vein thrombosis
  • immunothrombosis
  • cancer-associated thrombosis
  • catheter-related thrombosis

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Published Papers (1 paper)

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16 pages, 731 KB  
Systematic Review
Patient Satisfaction with Anticoagulation for Venous Thromboembolic Disease: A Systematic Review of Oral and Parenteral Regiments
by Eleftheria Elmina Lefkou, Anastasia Fragkaki, Maria Mirsini Miliori, Dimitra Latsou, Kalliopi Panagiotopoulou, Paraskevi Kotsi, Grigorios Gerotziafas and Maria Geitona
Medicina 2026, 62(4), 783; https://doi.org/10.3390/medicina62040783 - 17 Apr 2026
Viewed by 533
Abstract
Background and Objectives: Venous thromboembolic disease (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of morbidity and mortality worldwide and imposes a substantial financial burden on health systems due to both the direct and indirect costs [...] Read more.
Background and Objectives: Venous thromboembolic disease (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of morbidity and mortality worldwide and imposes a substantial financial burden on health systems due to both the direct and indirect costs of acute management and long-term complications. This systematic review aimed to assess patient satisfaction with anticoagulation therapy for VTE and to highlight potential differences according to the type of anticoagulant. The review focused on factors influencing the patient experience, such as perceived efficacy, ease of use, adverse effects, and health-related quality of life. Materials and Methods: A systematic review, without quantitative meta-analysis, was conducted in accordance with PRISMA 2020 guidelines. Articles were identified through searches in major databases (PubMed, Scopus, Cochrane Library and others) using keywords including “patient satisfaction”, “anticoagulation”, “venous thromboembolic disease”, and “quality of life”. In total, 21 studies published between 2009 and 2025 met the inclusion criteria. The studies assessed patient satisfaction with different types of anticoagulation, including vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs), and low-molecular-weight heparin (LMWH) injections. Results: Across the included studies, patients generally reported higher levels of treatment satisfaction with DOACs compared with VKAs, mainly due to the absence of routine laboratory monitoring and fewer dietary restrictions. However, satisfaction varied according to age, sex, and clinical status. In specific patient populations, such as those with cancer-associated thrombosis, factors including fewer drug–drug interactions and perceptions of safety with LMWH appeared to influence treatment choice and satisfaction. Adverse effects, particularly bleeding, were identified as major drivers of dissatisfaction. Several studies suggested that higher treatment satisfaction was associated with better adherence, while quality of life appeared to improve in patients treated with DOACs in comparison with VKAs. Conclusions: Patient satisfaction is a critical component of successful VTE management. Overall, DOACs appear to be associated with higher treatment satisfaction than traditional therapies such as VKAs, although further high-quality research is needed to individualise anticoagulation strategies. Systematic incorporation of patient-reported satisfaction into clinical decision-making and into international guidelines may improve adherence, enhance quality of life, and ultimately increase the effectiveness of anticoagulation therapy. Full article
(This article belongs to the Special Issue Venous Thromboembolism: Diagnosis, Management, and Treatment)
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