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Advances in the Treatment and Rehabilitation of Stroke Patients

A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Neurology".

Deadline for manuscript submissions: 20 March 2027 | Viewed by 316

Editors


E-Mail Website
Guest Editor
Department of Health Sciences, University of Burgos, Burgos, Spain
Interests: stroke rehabilitation; neurological physiotherapy; neurorehabilitation; functional recovery; disability; therapeutic exercise; quality of life; patient-centered care; multidisciplinary rehabilitation; health sciences

E-Mail Website
Guest Editor
Department of Health Sciences, University of Burgos, Burgos, Spain
Interests: stroke rehabilitation; neurorehabilitation; neurological physiotherapy; functional recovery; motor recovery; neuroplasticity; rehabilitation technologies; therapeutic exercise; quality of life; multidisciplinary care

Special Issue Information

Dear Colleagues,

Stroke remains one of the leading causes of mortality and long-term disability worldwide, representing a major clinical, social, and economic challenge. Despite substantial advances in prevention and acute stroke management, many survivors continue to experience persistent motor, cognitive, communicative, swallowing, and functional impairments that significantly affect independence and quality of life. Consequently, there is a growing need for innovative, multidisciplinary, and evidence-based approaches aimed at improving recovery and long-term outcomes in stroke patients.

This Special Issue, entitled “Advances in the Treatment and Rehabilitation of Stroke Patients”, aims to provide an updated overview of current developments and emerging trends in stroke treatment and neurorehabilitation. The scope of this Special Issue includes acute stroke management, secondary prevention, neuroplasticity, motor and cognitive recovery, functional rehabilitation, dysphagia management, assistive technologies, telerehabilitation, robotic rehabilitation, virtual reality, wearable devices, and the implementation of artificial intelligence in clinical practice.

Particular attention will be given to multidisciplinary and patient-centered approaches that promote functional independence, participation, and quality of life. This Special Issue also seeks to explore innovative therapeutic strategies and translational research that may contribute to optimizing rehabilitation outcomes and healthcare delivery for stroke survivors.

We welcome original research articles, systematic reviews, meta-analyses, clinical studies, and high-quality narrative reviews related to stroke treatment and rehabilitation.

We look forward to receiving your valuable contributions.

Dr. Jessica Fernández-Solana
Dr. Mirian Santamaría-Peláez
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • neurorehabilitation
  • functional recovery
  • neuroplasticity
  • stroke treatment
  • robotic rehabilitation
  • telerehabilitation
  • artificial intelligence
  • virtual reality
  • multidisciplinary care
  • quality of life

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Published Papers (1 paper)

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Research

24 pages, 2216 KB  
Article
Pre-Thrombolysis Biological Correlates of Admission Glasgow Coma Scale in Older Adults with Acute Ischemic Stroke: A Retrospective Single-Center Cohort Study
by Sorina Nicoleta Munteanu, Adrian Stan, Aurel Nechita, Dorel Firescu, Mihai Cristian Marinescu, Claudiu Elisei Tanase, Ioana Navalici, Dana Tutunaru, Mihaela Moisei and Aurelia Romila
Medicina 2026, 62(9), 1692; https://doi.org/10.3390/medicina62091692 - 3 Sep 2026
Viewed by 173
Abstract
Background and Objectives: Biological correlates of baseline clinical responsiveness remain incompletely characterized in older adults with acute ischemic stroke treated with intravenous thrombolysis. We evaluated associations between admission Glasgow Coma Scale (GCS) and pre-thrombolysis hematologic, inflammatory, iron-status, and micronutrient parameters. Materials and [...] Read more.
Background and Objectives: Biological correlates of baseline clinical responsiveness remain incompletely characterized in older adults with acute ischemic stroke treated with intravenous thrombolysis. We evaluated associations between admission Glasgow Coma Scale (GCS) and pre-thrombolysis hematologic, inflammatory, iron-status, and micronutrient parameters. Materials and Methods: This retrospective single-center cohort included 95 unique patients aged ≥65 years, all treated with intravenous alteplase between 2020 and 2024. Admission GCS ranged from 11 to 14. Spearman correlations used original GCS scores. Principal proportional odds models used ordered GCS categories of 11–12, 13, and 14, and were adjusted for age, sex, and admission National Institutes of Health Stroke Scale (NIHSS), with false discovery rate corrections. Sensitivity analyses additionally considered clinician-documented aphasia, congestive heart failure, atrial fibrillation, and reperfusion status for 24 h GCS change. Results: Admission GCS correlated most strongly with RDW-CV (rho = −0.843; 95% bootstrap CI, −0.892 to −0.774) and MCV (rho = 0.779; 95% CI, 0.668 to 0.866). Principal adjusted odds ratios per one-SD increase were 5.68 for hemoglobin, 3.01 for log-transformed ferritin, 4.71 for serum iron, 4.71 for log-transformed vitamin B12, 0.20 for C-reactive protein, and 0.019 for RDW-CV (all FDR-adjusted p < 0.001). Association directions remained consistent in sensitivity analyses. MCV showed an exploratory nonlinear association. No biomarker was associated with the direction of 24 h GCS change after FDR correction, including reperfusion-adjusted models. Conclusions: Pre-thrombolysis biological parameters were concurrently associated with baseline GCS within this single-center cohort and restricted GCS range. These associations do not establish causality, independence from unmeasured lesion location or infarct volume, predictive utility, or early neurological recovery. Prospective external validation is required. Full article
(This article belongs to the Special Issue Advances in the Treatment and Rehabilitation of Stroke Patients)
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