Diabetes and Cardiovascular Disease: Addressing Mechanisms and Therapeutic Strategies Across the Cardiometabolic Continuum
A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Cardiology".
Deadline for manuscript submissions: 30 October 2026 | Viewed by 2082
Editors
Interests: clinical cardiology; angiology; cardiovascular imaging; diabetic heart disease; cardiometabolism
Interests: diabetes treatment; cardiovascular disease prevention; antidiabetic agents; exercise; hypoglycemia; continuous glucose monitoring
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to introduce this Special Issue on “Diabetes and Cardiovascular Disease: Addressing Mechanisms and Therapeutic Strategies Across the Cardiometabolic Continuum”.
Diabetes mellitus represents a major global public health challenge and is among the leading causes of morbidity and mortality worldwide. In addition to its detrimental effects on quality of life and functional capacity, diabetes is associated with a broad spectrum of chronic complications encompassing both microvascular and macrovascular disease, as well as acute metabolic disturbances.
Macrovascular complications, namely coronary artery disease, stroke, and peripheral artery disease—collectively referred to as atherosclerotic cardiovascular disease—account for the majority of deaths and healthcare expenditures in people living with diabetes.
Cardiovascular disease remains the dominant cause of mortality in this population, with approximately 70% of individuals with diabetes aged ≥65 years dying from cardiovascular causes.
Beyond atherosclerotic disease, diabetes mellitus is an independent risk factor for heart failure, with observational studies demonstrating a two- to five-fold increased risk compared with individuals without diabetes, accompanied by poorer clinical outcomes.
These data underscore that diabetes and cardiovascular disease are interrelated, co-evolving manifestations along a shared cardiometabolic continuum.
Despite substantial progress in glycemic control, lipid management, and blood pressure reduction, residual cardiometabolic risk remains high, highlighting persistent gaps in mechanistic understanding and therapeutic implementation. This evolving field represents both significant challenges and important opportunities, particularly in elucidating pathogenic pathways linking metabolic dysfunction to cardiovascular injury and in developing integrated, disease-modifying treatment strategies.
This Special Issue aims to present the most recent advances related to mechanisms and therapeutic strategies addressing diabetes and cardiovascular disease across the cardiometabolic continuum. We welcome contributions covering basic, translational, and clinical research, including cardiometabolic pathophysiology, atherosclerotic cardiovascular disease, heart failure in diabetes, cardioprotective glucose-lowering therapies, residual cardiovascular risk, and integrated cardiometabolic care models.
We look forward to your contributions and to sharing research that advances the understanding, prevention, and management of diabetes and cardiovascular disease in an integrated, patient-centered manner.
Dr. Petra Grubić Rotkvić
Guest Editor Assistant
Dr. Maja Cigrovski Berković
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes mellitus
- cardiovascular disease
- cardiometabolism
- diabetic heart disease
- atherosclerosis
- diabetic macrovascular complications
- diabetes treatment
- obesity
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