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Medicina
Special Issues
Updates on Risk Factors, Prevention and Treatment of Knee Disease
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Updates on Risk Factors, Prevention and Treatment of Knee Disease

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3507

Special Issue Editors

Prof. Dr. Giuseppe Solarino

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Guest Editor
Orthopaedic and Trauma Unit, Department of Basic Medical Sciences, Neurscience and Sense Organs, School of Medicine, AOU Consorziale Policlinico, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy
Interests: knee; trauma; fracture; hip; arthroplasty
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giuseppe Maccagnano

E-Mail Website
Guest Editor
Orthopaedics Unit, Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia, 71122 Foggia, Italy
Interests: shoulder; knee; hip; trauma
Special Issues, Collections and Topics in MDPI journals
Dr. Michele Coviello

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Guest Editor Assistant
Orthopaedics Unit, Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia, 71122 Foggia, Italy
Interests: shoulder; knee; arthroscopy; trauma; fracture

Special Issue Information

Dear Colleagues,

The knee joint is a complex structure susceptible to a wide range of pathologies, each with significant implications for patient function and quality of life. While osteoarthritis has been a primary focus in knee research, other conditions such as fractures and ligament and meniscus injuries also contribute substantially to the burden of knee disease. A comprehensive Special Issue addressing the spectrum of knee pathologies is necessary to advance our understanding, prevention, and treatment strategies.

This Special Issue aims to provide a comprehensive overview of the latest research and clinical practices in knee pathology, covering the aetiology, risk factors, prevention, diagnosis, treatment options, rehabilitation, and patient outcomes. This issue will also explore biomechanics, imaging, regenerative medicine, and patient-centred care aspects related to knee health.

In addition, authors are encouraged to submit papers discussing surgical treatments and conservative strategies for knee disease.

These contributions can be in the form of original articles, technical notes, or review articles.

Prof. Dr. Giuseppe Solarino
Prof. Dr. Giuseppe Maccagnano
Guest Editors

Dr. Michele Coviello
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sports medicine
  • trauma
  • degenerative
  • regenerative
  • rehabilitation
  • prevention

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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14 pages, 682 KiB  
Article
Anterolateral Ligament Reconstruction Combined with Anterior Cruciate Ligament Reconstruction: Clinical and Functional Outcomes
by Giuseppe Danilo Cassano, Lorenzo Moretti, Michele Coviello, Ilaria Bortone, Mariapia Musci, Ennio Favilla and Giuseppe Solarino
Medicina 2025, 61(6), 1011; https://doi.org/10.3390/medicina61061011 - 28 May 2025
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Abstract
Background and Objectives: The anterior cruciate ligament (ACL) is crucial for knee stability, preventing anterior displacement of the tibia and rotation relative to the femur. Despite ACL reconstruction (ACLR), residual instability is common, affecting knee function. Anterolateral ligament reconstruction (ALLR) alongside ACLR [...] Read more.
Background and Objectives: The anterior cruciate ligament (ACL) is crucial for knee stability, preventing anterior displacement of the tibia and rotation relative to the femur. Despite ACL reconstruction (ACLR), residual instability is common, affecting knee function. Anterolateral ligament reconstruction (ALLR) alongside ACLR improves outcomes, as the ALL plays a significant role in rotational stability. This study aims to assess the clinical and functional outcomes of the ACLR+ALLR combination using biomechanical testing in patients with at least ten months of follow-up. Materials and Methods: This cross-sectional comparative cohort study involves patients with ACLR. Inclusion criteria were adult patients who underwent ACLR within the last 3 years, with the same surgical technique performed by a single operator. Patients underwent anamnestic and clinical evaluation and completed Lysholm and KOOS questionnaires. Biomechanical tests included a Unilateral Drop Jump, a Countermovement Jump with knee rotation, and a five-repetition Sit-To-Stand. Force platforms, a camera, and surface electromyography were used to assess biomechanical stability and joint function. Results: This study included 18 subjects, 5 with ACLR and ALLR, and 13 with ACLR alone. The groups showed no significant differences in the KOOS and Lysholm scales and clinical outcomes. Muscle trophism reduction compared to the contralateral limb was noted in both groups. Biomechanical evaluations showed no difference in Quadriceps muscle activity during the landing phase of the Drop Jump. However, the ACL-ALL group exhibited fewer spikes and fewer knee joint angular excursions during ground impact stabilization. In the 5-STS task, a significant difference was observed in the vertical force peak. Differences in muscle activity during foot rotation and force components during the jumping phase were noted in the Countermovement Jump. Conclusions: ACLR combined with ALLR shows similar perceived joint function but improved biomechanical joint stability. Further studies with larger samples and longer follow-ups are needed for validation. Full article
(This article belongs to the Special Issue Updates on Risk Factors, Prevention and Treatment of Knee Disease)
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17 pages, 2811 KiB  
Systematic Review
Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials—SYSADOAs Are Effective and Safe for Knee OA
by Yong-Beom Park and Jun-Ho Kim
Medicina 2025, 61(2), 331; https://doi.org/10.3390/medicina61020331 - 13 Feb 2025
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Abstract
Background and Objective: According to international guidelines, glucosamine and chondroitin, regarded as slow-acting drugs for osteoarthritis (SYSADOAs), have been first-line treatments for knee osteoarthritis (OA); however, their efficacies remain controversial. Additionally, the efficacies of plant extract cocktails, SKI306X, and its newer formulation, [...] Read more.
Background and Objective: According to international guidelines, glucosamine and chondroitin, regarded as slow-acting drugs for osteoarthritis (SYSADOAs), have been first-line treatments for knee osteoarthritis (OA); however, their efficacies remain controversial. Additionally, the efficacies of plant extract cocktails, SKI306X, and its newer formulation, SKCPT, have not been well investigated. To evaluate the effectiveness and safety of symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) in patients with knee OA. Materials and Methods: Electronic databases were systematically searched to identify randomized controlled trials (RCTs) assessing the effectiveness and safety of SYSADOAs, including chondroitin sulfate, glucosamine sulfate, and SKCPT/SKI306X. The outcomes included pain relief, functional improvements, and safety profiles. The outcome measurements were compared between the treatment and control groups, including placebo and non-placebo groups, within and after 3 months of follow-up. Results: Analysis of 21 RCTs showed significantly greater improvement in pain relief in the treatment group compared with the placebo group both within (standard mean difference [SMD], 0.38; 95% confidence interval [CI], 0.18–0.57; p < 0.001) and after 3 months of follow-up (SMD, 0.22; 95%CI, 0.03–0.42 p = 0.023). The treatment group also showed significantly greater functional improvements regardless of follow-up. Pain and functional improvement did not differ significantly between the treatment and non-placebo groups. Regarding the safety profile, the risk ratios did not differ significantly between the treatment and control groups, including the placebo and non-placebo subgroups. Conclusions: Glucosamine, chondroitin, and SKCPT/SKI306X improved the pain and function and were non-inferior to pharmacologic drugs for up to 12 months. These findings support the clinical use of these SYSADOAs to treat knee OA. Level of Evidence: Therapeutic Level II. Full article
(This article belongs to the Special Issue Updates on Risk Factors, Prevention and Treatment of Knee Disease)
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