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Skin Diseases: Causes, Impacts, and Advances in Treatment and Prevention

A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Dermatology".

Deadline for manuscript submissions: 20 April 2027 | Viewed by 320

Editors


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Guest Editor
Department of Dermatology, Jagiellonian University Medical College, Botaniczna 3, 31-503 Cracow, Poland
Interests: atopic dermatitis; biologics and targeted therapies in dermatology; skin barrier and microbiome; metabolism in the skin; superficial fungal infections; skin cancers

E-Mail Website
Guest Editor
Department of Dermatology, Jagiellonian University Medical College, Botaniczna 3, 31-503 Cracow, Poland
Interests: allergic dermatoses; atopic dermatitis;dermatologic mycology;tienas;dermatophytes
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Special Issue Information

Dear Colleagues,

Skin diseases are among the most common health conditions worldwide and cause a great burden for patients and health systems. They lead to sleep disturbance, psychosocial distress, and social stigma. Frequently, the impact of dermatological conditions remains underestimated due to the low immediate mortality rate. However, their real influence lies in the long-term morbidity and substantial social costs they entail.

Understanding skin diseases requires integrating knowledge of genetic and environmental factors that, in combination with behavioral factors, lead to distinct pathophysiological processes, including epidermal barrier disruption, dysregulation of immune system function, and alterations in the microbiome. There are complex relationships with other disorders, including immune, metabolic, and psychiatric conditions, which have a significant impact on the clinical presentation and the outcomes of the treatment. Finally, global-scale challenges emerge that include such biological factors as increasing resistance to antimicrobial treatment, but also societal factors such as inequities in access to modern diagnostic and therapeutic methods. The ultimate goal is to provide a preventive and precision-based system that will be based on patient-centered care.

The optimization of this process is only possible with a better understanding of the etiology of skin disorders. Current advances in targeted therapy have changed our view on treatment in dermatology, and more sophisticated tools are being developed to facilitate these therapeutic methods. On the other hand, the role of additional non-pharmacological approaches is being acknowledged—patient education, lifestyle modifications, and psychological interventions are foundations in multiple dermatoses. It is now time to highlight the direct relationship between disease etiology, its impact on patients' lives, and the resulting approach to not only treatment, but also prevention.

The goal of this Special Issue, “Skin Diseases: Causes, Impacts, and Advances in Treatment and Prevention”, is to gather high-quality works that investigate the mechanisms, epidemiology, and management of dermatologic disease, with a particular emphasis on innovative strategies. This Special Issue aims to cover a broad range of topics, focusing on the relationships between the pathophysiology of skin diseases, targeted prevention strategies, personalized medicine approaches, novel pharmacological treatments, and the role of health services in dermatological management.

We would like to invite researchers to submit their original work, reviews, and any other papers that will help to enhance our understanding and improve care for dermatological patients.

We look forward to receiving your contributions!

Dr. Przemysław Halubiec
Dr. Andrzej Jaworek
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin diseases
  • epidemiology
  • pathophysiology
  • immune dysregulation
  • skin barrier dysfunction
  • targeted therapy
  • precision medicine
  • prevention strategies
  • patient-centered care

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Published Papers (1 paper)

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Research

13 pages, 651 KB  
Article
Clinical Patterns in Patients with Basal Cell Carcinoma: A 10-Year Single-Center Retrospective Study
by Eliza Rebeka Siemaszko-Oniszczuk, Przemysław Hałubiec, Anna Wojas-Pelc and Andrzej Kazimierz Jaworek
Medicina 2026, 62(9), 1696; https://doi.org/10.3390/medicina62091696 - 4 Sep 2026
Abstract
Background and Objectives: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer, and its global incidence rate constantly rises. However, there are no current epidemiological data for many regions, including Małopolska in southern Poland. This study aimed to characterize the [...] Read more.
Background and Objectives: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer, and its global incidence rate constantly rises. However, there are no current epidemiological data for many regions, including Małopolska in southern Poland. This study aimed to characterize the clinical and histological profile of patients with BCC and to identify factors associated with local recurrence and the presence of multiple tumors. Materials and Methods: We performed a single-center, retrospective observational study consistent with STROBE guidelines at the Department of Dermatology and Allergology, University Hospital in Cracow. The included patients were adults with at least one histologically confirmed BCC treated between 2015 and 2025. Demographic, clinical, histopathological, and follow-up data were collected at patient and lesion levels. The results were evaluated using univariable tests, multivariable logistic regression, Kaplan–Meier survival analysis, and generalized estimating equations. Results: We included 108 patients (median age at first diagnosis, 73 years; 52% male) with 418 BCCs; the median follow-up duration was 84 months. Superficial BCC was the most common subtype among lesions with available histological subtype information (56%). The head and neck region was the most frequent anatomical site in this group (51%). Multiple BCCs were present in 62% of patients. Longer follow-up was independently associated with the presence of multiple BCCs. A history of actinic keratoses showed a positive but statistically nonsignificant association with multiple BCCs. Recurrence was observed in 15 lesions (3.6%). Female sex and H-zone involvement showed higher odds of recurrence. Conclusions: In this elderly cohort, multiple BCC tumors may reflect longer follow-up and cumulative actinic damage. Recurrence was relatively infrequent but associated with clinically relevant features, including H-zone involvement and female sex. These findings support an individualized, multifactorial approach to treatment and follow-up, taking into account age, sex, lesion burden, anatomical location, and histological subtype. Full article
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