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Surface Modification of Functional Scaffolds and Biomaterials
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Surface Modification of Functional Scaffolds and Biomaterials

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 12484

Special Issue Editor

Prof. Dr. Anderson de Oliveira Lobo

E-Mail Website
Guest Editor
Department of Materials Engineering, Federal University of Piauí, Teresina, Brazil
Interests: biomaterials; tissue engineering; biocompatibility in vitro and in vivo assays polymers; bioceramics; metal alloys; spinning techniques; plasma etching; atomic layer deposition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Functional scaffolds and biomaterials for tissue engineering place high demands on materials and exceed the passive biocompatibility requirements previously considered acceptable for biomedical implants. Along with (bio)-degradability, the activation of specific cell–material interactions and a three-dimensional environment that mimics the nanostructured components of the human body are challenges and pre-requisites for the organization of living cells in functional tissues. In this Special Issue, we will focus on papers related to rational design, surface modifications, and characterization of functional biomaterials, including hydrogels and stimuli-responsive materials.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome. Critical reviews on specific modern topics such as bio-compatibility of functional scaffolds and biomimetic materials are particularly welcome. The authors are encouraged to submit manuscripts reporting unexpected results, providing they can present scientifically spotless explanations.

Prof. Dr. Anderson Oliveira Lobo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomimetic materials
  • Self-assembly
  • Bioprinting functional hydrogels to mimic natural tissues
  • Hydrogels
  • Nanoceramics
  • Atomic layer deposition
  • Surface properties
  • Nanostructuring
  • Functionalization

Published Papers (4 papers)

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Research

21 pages, 6657 KiB  
Article
Development of Composite Scaffolds Based on Cerium Doped-Hydroxyapatite and Natural Gums—Biological and Mechanical Properties
by Marcus Vinicius Beserra dos Santos, Lorenna Bastos Nogueira Rocha, Ewerton Gomes Vieira, Ana Leite Oliveira, Anderson Oliveira Lobo, Maria Acelina Martins de Carvalho, Josy Anteveli Osajima and Edson Cavalcanti Silva-Filho
Materials 2019, 12(15), 2389; https://doi.org/10.3390/ma12152389 - 26 Jul 2019
Cited by 22 | Viewed by 3617
Abstract
Hydroxyapatite (HAp) is a ceramic material composing the inorganic portion of bones. Ionic substitutions enhance characteristics of HAp, for example, calcium ions (Ca2+) by cerium ions (Ce3+). The use of HAp is potentialized through biopolymers, cashew gum (CG), and [...] Read more.
Hydroxyapatite (HAp) is a ceramic material composing the inorganic portion of bones. Ionic substitutions enhance characteristics of HAp, for example, calcium ions (Ca2+) by cerium ions (Ce3+). The use of HAp is potentialized through biopolymers, cashew gum (CG), and gellan gum (GG), since CG/GG is structuring agents in the modeling of structured biocomposites, scaffolds. Ce-HApCG biocomposite was synthesized using a chemical precipitation method. The obtained material was frozen (–20 °C for 24 h), and then vacuum dried for 24 h. The Ce-HApCG was characterized by X-Ray diffractograms (XRD), X-ray photoemission spectra (XPS), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy dispersive spectroscopy (EDS). XRD and FTIR showed that Ce-HApCG was successfully synthesized. XRD showed characteristic peaks at 2θ = 25.87 and 32.05, corresponding to the crystalline planes (0 0 2) and (2 1 1), respectively, while phosphate bands were present at 1050 cm−1 and 1098 cm−1, indicating the success of composite synthesis. FESEM showed pores and incorporated nanostructured granules of Ce-HApCG. The mechanical test identified that Ce-HApCG has a compressive strength similar to the cancellous bone’s strength and some allografts used in surgical procedures. In vitro tests (MTT assay and hemolysis) showed that scaffold was non-toxic and exhibited low hemolytic activity. Thus, the Ce-HApCG has potential for application in bone tissue engineering. Full article
(This article belongs to the Special Issue Surface Modification of Functional Scaffolds and Biomaterials)
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16 pages, 3296 KiB  
Article
In Vivo Evaluation of the Genotoxic Effects of Poly (Butylene adipate-co-terephthalate)/Polypyrrole with Nanohydroxyapatite Scaffolds for Bone Regeneration
by Conceição de Maria Vaz Elias, Antônio Luiz Martins Maia Filho, Laryssa Roque da Silva, Fabrício Pires de Moura do Amaral, Thomas J. Webster, Fernanda Roberta Marciano and Anderson Oliveira Lobo
Materials 2019, 12(8), 1330; https://doi.org/10.3390/ma12081330 - 24 Apr 2019
Cited by 11 | Viewed by 3122
Abstract
Here, butylene adipate-co-terephthalate/polypyrrole with nanohydroxyapatite (PBAT/PPy/nHAp) scaffolds were fabricated and characterized. The electrospinning process was carried out using 12 kV, a needle of 23 G, an infusion pump set at 0.3 mL/h, and 10 cm of distance. Afterwards, nHAp was directly electrodeposited onto [...] Read more.
Here, butylene adipate-co-terephthalate/polypyrrole with nanohydroxyapatite (PBAT/PPy/nHAp) scaffolds were fabricated and characterized. The electrospinning process was carried out using 12 kV, a needle of 23 G, an infusion pump set at 0.3 mL/h, and 10 cm of distance. Afterwards, nHAp was directly electrodeposited onto PBAT/PPy scaffolds using a classical three-electrode apparatus. For in vivo assays (comet assay, acute and chronic micronucleus), 60 male albino Wistar rats with 4 groups were used in each test (n = 5): PBAT/PPy; PBAT/PPy/nHAp; positive control (cyclophosphamide); and the negative control (distilled water). Peripheral blood samples were collected from the animals to perform the comet test after 4 h (for damage) and 24 h (for repair). In the comet test, it was shown that the scaffolds did not induce damage to the % DNA tail and neither for tail length. After the end of 48 h (for acute micronucleus) and 72 h (for chronic micronucleus), bone marrow was collected from each rat to perform the micronucleus test. All of the produced scaffolds did not present genotoxic effects, providing strong evidence for the biological application of PBAT/PPy/nHAp scaffolds. Full article
(This article belongs to the Special Issue Surface Modification of Functional Scaffolds and Biomaterials)
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18 pages, 5303 KiB  
Article
Use of Statistical Design Strategies to Produce Biodegradable and Eco-Friendly Films from Cashew Gum Polysaccharide and Polyvinyl Alcohol
by Maurício V. Cruz, Marcos A. Pereira-Júnior, Karla A. Batista and Kátia F. Fernandes
Materials 2019, 12(7), 1149; https://doi.org/10.3390/ma12071149 - 09 Apr 2019
Cited by 4 | Viewed by 2396
Abstract
This work reports the production and characterization of biodegradable and eco-friendly films based on cashew gum polysaccharide (CGP) and polyvinyl alcohol (PVA), using the statistical design strategy. Results show that CGP/PVA films are pH stimuli-responsive, allowing their use in a magnitude of biotechnological [...] Read more.
This work reports the production and characterization of biodegradable and eco-friendly films based on cashew gum polysaccharide (CGP) and polyvinyl alcohol (PVA), using the statistical design strategy. Results show that CGP/PVA films are pH stimuli-responsive, allowing their use in a magnitude of biotechnological applications. The morphological and dimensional characterization evidences a positive influence of polymers in the dimensional properties. In addition, the microstructural analysis shows that films have different morphologies depending on the content of polymers and oxidant agent. On the other hand, the thickness and light transmission values are positively influenced by CGP and PVA and negatively influenced by NaIO4. Results from mechanical properties show that the traction force is positively influenced by NaIO4, while the elongation is only affected by the PVA concentration. In summary, considering the morphological, optical and mechanical properties of the CGP/PVA films it is possible to suggest their utilization in different fields as promising packaging materials or matrices for immobilization and/or encapsulation of biomolecules. Full article
(This article belongs to the Special Issue Surface Modification of Functional Scaffolds and Biomaterials)
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13 pages, 2422 KiB  
Article
Cell Viability of Porous Poly(d,l-lactic acid)/Vertically Aligned Carbon Nanotubes/Nanohydroxyapatite Scaffolds for Osteochondral Tissue Engineering
by Thiago Domingues Stocco, Eliane Antonioli, Conceição de Maria Vaz Elias, Bruno Vinícius Manzolli Rodrigues, Idália Aparecida Waltrick de Brito Siqueira, Mario Ferretti, Fernanda Roberta Marciano and Anderson Oliveira Lobo
Materials 2019, 12(6), 849; https://doi.org/10.3390/ma12060849 - 13 Mar 2019
Cited by 19 | Viewed by 2852
Abstract
Treatment of articular cartilage lesions remains an important challenge. Frequently the bone located below the cartilage is also damaged, resulting in defects known as osteochondral lesions. Tissue engineering has emerged as a potential approach to treat cartilage and osteochondral defects. The principal challenge [...] Read more.
Treatment of articular cartilage lesions remains an important challenge. Frequently the bone located below the cartilage is also damaged, resulting in defects known as osteochondral lesions. Tissue engineering has emerged as a potential approach to treat cartilage and osteochondral defects. The principal challenge of osteochondral tissue engineering is to create a scaffold with potential to regenerate both cartilage and the subchondral bone involved, considering the intrinsic properties of each tissue. Recent nanocomposites based on the incorporation of nanoscale fillers into polymer matrix have shown promising results for the treatment of osteochondral defects. In this present study, it was performed using the recently developed methodologies (electrodeposition and immersion in simulated body fluid) to obtain porous superhydrophilic poly(d,l-lactic acid)/vertically aligned carbon nanotubes/nanohydroxyapatite (PDLLA/VACNT-O:nHAp) nanocomposite scaffolds, to analyze cell behavior and gene expression of chondrocytes, and then assess the applicability of this nanobiomaterial for osteochondral regenerative medicine. The results demonstrate that PDLLA/VACNT-O:nHAp nanocomposite supports chondrocytes adhesion and decreases type I Collagen mRNA expression. Therefore, these findings suggest the possibility of novel nanobiomaterial as a scaffold for osteochondral tissue engineering applications. Full article
(This article belongs to the Special Issue Surface Modification of Functional Scaffolds and Biomaterials)
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