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Biomaterials Modification, Characterization and Applications
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Biomaterials Modification, Characterization and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 3020

Special Issue Editor

Prof. Dr. Wanjun Liu

E-Mail Website
Guest Editor
College of Textiles, Donghua University, Shanghai 201620, China
Interests: biomaterials; islet encapsulation; bioprinting; hydrogels; nanofibers; textiles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials play crucial roles in various fields, including medicine, tissue engineering, and drug delivery, due to their ability to interact with biological systems. The modification, characterization, and application of biomaterials are key areas of research for improving their performances and expanding their range of uses.

The modification of biomaterials involves tailoring their properties to meet specific requirements for different applications. This can include making surface modifications to enhance biocompatibility, the incorporation of bioactive molecules to promote cell adhesion or changes in mechanical properties for tissue engineering applications.

The characterization of biomaterials is essential to understand their structures, properties, and interactions with biological systems. Techniques such as spectroscopy, microscopy, mechanical testing, and degradation studies are typically used to analyze the chemical compositions, morphologies, mechanical strengths, degradation kinetics, and biological responses of biomaterials.

The applications of biomaterials are diverse and include medical implants, drug delivery systems, scaffolds for tissue regeneration, and diagnostic tools. Biomaterials are used in orthopedic implants, dental materials, cardiovascular devices, and neural interfaces, among others, to improve patient outcomes and quality of life.

Overall, the field of biomaterials continues to evolve through advancements in their modification, characterization, and innovative application, enabling progress in healthcare, biotechnology, and materials science.

This Special Issue will cover current research progress on developing novel biomaterials with enhanced properties, improving characterization techniques to better understand their behavior in complex environments, and exploring new applications in emerging fields such as bioelectronics and personalized medicine.

You may choose our Joint Special Issue in Polymers.

Prof. Dr. Wanjun Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • tissue engineering
  • drug delivery
  • biomedicine

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Published Papers (2 papers)

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20 pages, 6734 KB  
Article
Modification of Natural Clays with Magnetite to Provide Boosted Antimicrobial Properties and Chemopreventive Activity Against Melanoma
by Alicja Wójcik, Jakub Matusiak, Marta Trzaskowska, Aleksandra Maciejczyk, Paulina Kazimierczak, Katarzyna Suśniak, Krzysztof Palka, Izabela Korona-Glowniak, Wojciech Franus and Agata Przekora
Materials 2025, 18(20), 4759; https://doi.org/10.3390/ma18204759 - 17 Oct 2025
Viewed by 600
Abstract
Historically, clays have been widely used for the treatment of wounds and to stop hemorrhaging. The aim of this study was to combine four natural clay minerals (kaolinite, glauconite, montmorillonite, and bentonite) with magnetite (Fe3O4) nanoparticles to produce Fe [...] Read more.
Historically, clays have been widely used for the treatment of wounds and to stop hemorrhaging. The aim of this study was to combine four natural clay minerals (kaolinite, glauconite, montmorillonite, and bentonite) with magnetite (Fe3O4) nanoparticles to produce Fe3O4–clay complexes with enhanced antimicrobial properties and chemopreventive activity against melanoma. The magnetite–clay complexes were synthesized by the chemical co-precipitation method and characterized using XRD, TEM, STEM-EDS, SEM, and SQUID magnetometer. Antimicrobial properties were determined by evaluation of MIC values. The most promising materials were also subjected to direct contact antibacterial test according to the OECD standard for porous materials. Cytotoxicity of the complexes towards melanoma cells and normal human skin fibroblasts was assessed by MTT assay. We performed XRD, which confirmed the formation of Fe3O4–clay complex materials. It was also proven that complexes exhibited superparamagnetic properties. Microbiological experiments clearly revealed that modification of natural clays with magnetite significantly boosted their antimicrobial properties. Fe3O4–montmorillonite and Fe3O4–bentonite showed the strongest antimicrobial activity. Moreover, the mentioned complexes had the ability to reduce the viability of melanoma cells by 35–40%, while exhibiting no cytotoxicity against the normal human fibroblast (BJ) cell line, which is an extremely desirable feature. Thus, it may be concluded that Fe3O4–montmorillonite and Fe3O4–bentonite complexes hold promise for use in the management of infected wounds and wounds after melanoma excision. Full article
(This article belongs to the Special Issue Biomaterials Modification, Characterization and Applications)
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25 pages, 6838 KB  
Article
Films Based on Chitosan/Konjac Glucomannan Blend Containing Resveratrol for Potential Skin Application
by Karolina Kulka-Kamińska, Marzanna Kurzawa and Alina Sionkowska
Materials 2025, 18(2), 457; https://doi.org/10.3390/ma18020457 - 20 Jan 2025
Cited by 1 | Viewed by 1886
Abstract
Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is a natural substance that exhibits a range of biological activities, including the scavenging of free radicals and anti-inflammatory and anti-aging effects. In this [...] Read more.
Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is a natural substance that exhibits a range of biological activities, including the scavenging of free radicals and anti-inflammatory and anti-aging effects. In this study, chitosan/konjac glucomannan resveratrol-enriched thin films were prepared. The enrichment of biomaterials with active ingredients is a common practice, as it allows the desired properties to be obtained in the final product. To characterize the films, several analyses were performed, including infrared spectroscopy, imaging of the samples by SEM and AFM techniques, swelling analysis in pH 5.5 and 7.4, mechanical and antioxidant assays, contact angle measurements, and determination of the resveratrol release profile under the skin mimicking conditions. Resveratrol incorporation into the matrices resulted in modifications to the chemical structure and film morphology. The mechanical characteristics of films with additives were found to undergo deterioration. The sample containing 10% of resveratrol exhibited a higher swelling degree than other films. The resveratrol-modified films demonstrated a notable antioxidant capacity, a reduced contact angle, and enhanced wettability. The resveratrol release occurred rapidly initially, with a maximum of 84% and 56% of the substance released depending on the sample type. Thus, the proposed formulations have promising properties, in particular good swelling capacity, high antioxidant potential, and improved wettability, and may serve as skin dressings after further investigation. Full article
(This article belongs to the Special Issue Biomaterials Modification, Characterization and Applications)
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