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Special Issue "Fluorescent Sensors for Selective Detection"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: 14 December 2018

Special Issue Editor

Guest Editor
Assoc. Prof. Hisashi Satoh

Division of Environmental Engineering, Faculty of Engineering, Hokkaido University
Website | E-Mail
Interests: sensor development; wastewater treatments; environmental water quality management

Special Issue Information

Dear Colleagues,

Reliable detection of organic and inorganic matter and microorganisms is an important task for environmental monitoring, medical diagnostics, food safety, industrial quality control, agriculture and security. At present, we are using traditional analytical techniques, such as a gas or liquid chromatography, atomic absorption or emission spectroscopy (AAS/AES), inductively coupled plasma (ICP), mass spectroscopy and polymerase chain reaction (PCR), for their detection. These techniques are highly accurate and sensitive to specific analytes of interest, but they are costly, available only in large centralized laboratories and require extensive sample pre-treatment, making it difficult for on-site, real-time, or in situ detection. In light of these drawbacks, development of novel analytical methods, which have higher sensitivity and selectivity, a shorter response time, and lower costs, have attracted recent attention. Among the currently developed sensors, one based on fluorescence detection is one of the most common analytical tools due to simplicity, low cost, high sensitivity and fast response. In this Special Issue, we will welcome submissions on articles addressing the sensor technology based on fluorescence measurements.

Assoc. Prof. Hisashi Satoh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fluorescent sensor
  • Simple detection
  • On-site analysis
  • Sensitivity
  • Selectivity
  • Response time
  • Cost
  • Organic matter
  • Inorganic matter
  • Microorganisms

Published Papers (5 papers)

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Research

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Open AccessArticle A Straightforward Substitution Strategy to Tune BODIPY Dyes Spanning the Near-Infrared Region via Suzuki–Miyaura Cross-Coupling
Materials 2018, 11(8), 1297; https://doi.org/10.3390/ma11081297
Received: 2 July 2018 / Revised: 23 July 2018 / Accepted: 24 July 2018 / Published: 27 July 2018
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Abstract
In this study, a series of new red and near-infrared (NIR) dyes derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) were developed by introducing thiophene and its derivatives to the 3- and 5- positions of the dichloroBODIPY core. For the first time, cyclictriol boronates and N-methyliminodiacetic acid
[...] Read more.
In this study, a series of new red and near-infrared (NIR) dyes derived from 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) were developed by introducing thiophene and its derivatives to the 3- and 5- positions of the dichloroBODIPY core. For the first time, cyclictriol boronates and N-methyliminodiacetic acid (MIDA) boronate were used as organoboron species to couple with 3,5-dichloroBODIPY via the one-step Suzuki–Miyaura cross-coupling. Six kinds of thieno-expended BODIPY dyes were synthesized in acceptable yields ranging from 31% to 79%. All six dyes showed different absorption and emission wavelengths spanning a wide range (c.a. 600–850 nm) in the red and NIR regions with relatively high quantum yields (19–85%). Cellular imaging of 8-(2,6-dimethylphenyl)-re3,5-di(2-thienyl)-BODIPY (dye 1) was conducted using bovine cumulus cells, and the fluorescence microscopy images indicated that the chromophore efficiently accumulated and was exclusively localized in the cytoplasm, suggesting it could be utilized as a subcellular probe. All six dyes were characterized using 1H-NMR and mass spectrometry. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Selective Detection)
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Figure 1

Open AccessFeature PaperArticle Specificities and Efficiencies of Primers Targeting Candidatus Phylum Saccharibacteria in Activated Sludge
Materials 2018, 11(7), 1129; https://doi.org/10.3390/ma11071129
Received: 7 May 2018 / Revised: 28 June 2018 / Accepted: 2 July 2018 / Published: 3 July 2018
PDF Full-text (2081 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Candidatus Saccharibacteria is a well-described candidate phylum that has not been successfully isolated. Nevertheless, its presence was suggested by 16S rRNA gene sequencing data, and it is frequently detected in natural environments and activated sludge. Because pure culture representatives of Candidatus Saccharibacteria are
[...] Read more.
Candidatus Saccharibacteria is a well-described candidate phylum that has not been successfully isolated. Nevertheless, its presence was suggested by 16S rRNA gene sequencing data, and it is frequently detected in natural environments and activated sludge. Because pure culture representatives of Candidatus Saccharibacteria are lacking, the specificity of primers for the determination of their abundance and diversity should be carefully evaluated. In this study, eight Candidatus Saccharibacteria-specific primers were selected from previous studies and evaluated for their coverage against a public database, annealing temperature of the combined primer sets, as well as their utilization to determine the detection frequencies and phylogenetic diversity by cloning analysis, and in quantification by quantitative polymerase chain reaction (PCR). Among the eight primers, four primers (TM7314F, TM7580F, TM7-910R, and TM7-1177R) showed high coverage. Cloning analysis showed that four primer sets (TM7314F and TM7-910R, TM7314F and TM7-1177R, TM7580F and TM7-910R, and TM7580F and TM7-1177R) yielded high detection frequencies for Candidatus Saccharibacteria in activated sludge from a wastewater treatment plant in Higashihiroshima City, Japan. Quantitative PCR results indicated that the primer set containing TM7314F and TM7-910R was superior for the specific detection of Candidatus Saccharibacteria in activated sludge. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Selective Detection)
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Open AccessArticle Extreme Ultraviolet to Visible Dispersed Single Photon Detection for Highly Sensitive Sensing of Fundamental Processes in Diverse Samples
Materials 2018, 11(6), 869; https://doi.org/10.3390/ma11060869
Received: 24 April 2018 / Revised: 17 May 2018 / Accepted: 17 May 2018 / Published: 23 May 2018
Cited by 1 | PDF Full-text (929 KB) | HTML Full-text | XML Full-text
Abstract
The detection of a single photon is the most sensitive method for sensing of photon emission. A common technique for single photon detection uses microchannel plate arrays combined with photocathodes and position sensitive anodes. Here, we report on the combination of such detectors
[...] Read more.
The detection of a single photon is the most sensitive method for sensing of photon emission. A common technique for single photon detection uses microchannel plate arrays combined with photocathodes and position sensitive anodes. Here, we report on the combination of such detectors with grating diffraction spectrometers, constituting a low-noise wavelength resolving photon spectroscopy apparatus with versatile applicability. We recapitulate the operation principle of such detectors and present the details of the experimental set-up, which we use to investigate fundamental mechanisms in atomic and molecular systems after excitation with tuneable synchrotron radiation. Extensions for time and polarization resolved measurements are described and examples of recent applications in current research are given. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Selective Detection)
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Figure 1

Open AccessArticle 3-[Bis(pyridin-2-ylmethyl)amino]-5-(4-carboxyphenyl)-BODIPY as Ratiometric Fluorescent Sensor for Cu2+
Materials 2018, 11(5), 814; https://doi.org/10.3390/ma11050814
Received: 8 April 2018 / Revised: 7 May 2018 / Accepted: 14 May 2018 / Published: 16 May 2018
PDF Full-text (2861 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
We developed an asymmetric fluorescent sensor 1 for Cu2+, based on 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY), by introducing 4-carboxyphenyl and bis(pyridin-2-ylmethyl)amine groups at the 5- and 3-positions, respectively, of the BODIPY core. We then investigated the photophysical and cation-sensing properties of the
[...] Read more.
We developed an asymmetric fluorescent sensor 1 for Cu2+, based on 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY), by introducing 4-carboxyphenyl and bis(pyridin-2-ylmethyl)amine groups at the 5- and 3-positions, respectively, of the BODIPY core. We then investigated the photophysical and cation-sensing properties of the sensor. BODIPY 1 showed large absorption and fluorescence spectral shifts on binding to Cu2+. The fluorescence peak at 580 nm red-shifted to 620 nm. The binding stoichiometry of BODIPY 1 and Cu2+ was 1:3. The ratio of the fluorescence intensity at 620 nm to that at 580 nm (F620/F580) increased with increasing concentration of Cu2+ (3–10 equiv); this enabled ratiometric determination of Cu2+. Although BODIPY 1 showed good selectivity for Cu2+, there was an interfering effect of Fe3+. BODIPY 1 could be used for the naked-eye detection of Cu2+ in a water-containing sample. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Selective Detection)
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Review

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Open AccessReview Recent Advances in Fluorescent Probes for Lipid Droplets
Materials 2018, 11(9), 1768; https://doi.org/10.3390/ma11091768
Received: 19 August 2018 / Revised: 14 September 2018 / Accepted: 14 September 2018 / Published: 18 September 2018
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Abstract
Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is
[...] Read more.
Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is of the highest importance to have reliable imaging tools. In this review, we focus on recent advances in the development of selective fluorescent probes for LDs. Their photophysical properties are described, and their advantages and drawbacks in fluorescence imaging are discussed. At last, we review the reported applications using these probes including two-photon excitation, in vivo and tissue imaging, as well as LDs tracking. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Selective Detection)
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Graphical abstract

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper:Article

Title:Single-photon detection for highly sensitive sensing of fundamental processes in all aggregate phases

Author(s) Andreas Hans, Philipp Schmidt, Christian Ozga, Arno Ehresmann, and André Knie 

Affiliation(s): Institute of Physics, University of Kassel, 34132 Kassel, Germany 

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