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Biomedical Nanostructured Materials and Coatings

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (15 October 2020) | Viewed by 3705

Special Issue Editors

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Guest Editor
Head of Department of Materials Science and Physics of Metals, Ufa University of Science and Technology, 32 Zaki Validi Street, 450000 Ufa, Russia
Interests: functional coatings; corrosion; plasma electrolytic processes
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Guest Editor
Ufa State Aviation Technical University, Ufa, Russia
Interests: bulk nanostructured materials; severe plastic deformation; nanotechnologies; medical implants

Special Issue Information

Dear Colleagues,

Since 1965, when Prof. Per-Ingvar Brånemark in Sweden put a first dental Ti implant into a volunteer, a vast human population has received medical treatments using materials and devices for internal fixation. One to five out of every hundred people surrounding us carry either a dental or an orthopedic implant. Unfortunately, 5% to 20% of the cases need a revision surgery because of various complications, including those induced by a foreign body reaction. Developing new biomedical materials and coatings is highly driven by the demands of this immense market, which has already reached 4 Billion USD worldwide for dental implants only, and which continues to grow with at least 5% CAGR.

New biomedical devices must be strong, smart, and friendly. Current advances in nanotechnologies offer a wide range of nanostructured materials and coatings showing higher strength and better short-term bioactivity and long-term biocompatibility than the previous generation of medical devices. For example, titanium alloy Ti-6Al-4V, being the most widely used for implant applications due to its high strength and bioinertness, carries 6% of aluminum proven to promote Alzheimer’s disease under long exposure. Its nanostructured alternative—commercially pure titanium—reaches the same and even higher strength. Moreover, nano-Ti does not carry unwanted alloying elements; therefore, stronger, smaller and safer implants are already being produced using this material. Numerous varieties of the surface treatments and coatings, both of inorganic and organic nature, help to fine tune the human body reaction to the device implantation. For example, titanium orthopedic joint replacement implants must have an osteoconductive coating in the area of the contact with the bone. By contrast, titanium plates used in traumatology should not osseointegrate, leaving the possibility to remove them after the fracture heals; therefore, this device should have a nonfouling coating. The coatings open up possibilities not only to produce different device types, but also to personalize the device itself, for example, through slow release of a drug prescribed to the person.

This Special Issue welcomes papers concerned with new bulk nanostructured metals and alloys obtained via severe plastic deformation (SPD) for biomedical applications. Nanostructuring of metallic materials by various SPD techniques comprises grain refinement of the microstructure down to a submicron or nanosized range, as well as the formation of nanoclusters and nanoprecipitates of a secondary phase, which essentially influences the mechanical and functional properties of the materials. With regard to medical applications, the creation of nanostructures in metals and alloys by SPD processing has been shown to improve mechanical, corrosion, and biomedical properties. Moreover, this Special Issue welcomes papers devoted to the surface modification of bulk nanomaterials and coatings, including nanostructured, nanolayer, nanoporous, nanoparticle-containing coatings obtained by anodizing, plasma electrolytic oxidation, physical and chemical vapor deposition, atomic layer deposition, and other techniques. Surface modification plays the most important role, creating the interface to the human body and improving the design and biocompatibility of the devices.

We believe that the cutting-edge research performed in this area and published in this Special Issue will contribute to the mass production of medical devices which will increase life expectancy and life quality in our society.

Therefore, the area of interest of this Special Issue Biomedical Nanostructured Materials and Coatings includes but is not limited to the following topics:

  1. Bulk nanostructured metallic materials for implant applications;
  2. Biodegradable nanostructured materials for temporary implants;
  3. Nanoporous coatings for biomedical applications;
  4. Multilayer nanostructured coatings for medical implants;
  5. Coatings with bioactive nanoparticles;
  6. Biomimetic materials and coatings;
  7. Interaction of coatings and nanostructured substrate as insights into the better biocompatibility.

Prof. Dr. Evgeny V. Parfenov
Prof. Dr. Ruslan Z. Valiev
Guest Editors

Manuscript Submission Information

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  • Bulk nanostructured metallic biomaterials
  • Nanostructured coatings
  • Metal implants
  • Biocompatible metal materials
  • Bioactive coatings

Published Papers (1 paper)

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20 pages, 6579 KiB  
Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages
by Tobias Schmitz, Maren Jannasch, Tobias Weigel, Claus Moseke, Uwe Gbureck, Jürgen Groll, Heike Walles and Jan Hansmann
Materials 2020, 13(5), 1142; - 4 Mar 2020
Cited by 9 | Viewed by 3207
Implants elicit an immunological response after implantation that results in the worst case in a complete implant rejection. This biomaterial-induced inflammation is modulated by macrophages and can be influenced by nanotopographical surface structures such as titania nanotubes or fractal titanium nitride (TiN) surfaces. [...] Read more.
Implants elicit an immunological response after implantation that results in the worst case in a complete implant rejection. This biomaterial-induced inflammation is modulated by macrophages and can be influenced by nanotopographical surface structures such as titania nanotubes or fractal titanium nitride (TiN) surfaces. However, their specific impact on a distinct macrophage phenotype has not been identified. By using two different levels of nanostructures and smooth samples as controls, the influence of tubular TiO2 and fractal TiN nanostructures on primary human macrophages with M1 or M2-phenotype was investigated. Therefore, nanotopographical coatings were either, directly generated by physical vapor deposition (PVD) or by electrochemical anodization of titanium PVD coatings. The cellular response of macrophages was quantitatively assessed to demonstrate a difference in biocompatibility of nanotubes in respect to human M1 and M2-macrophages. Depending on the tube diameter of the nanotubular surfaces, low cell numbers and impaired cellular activity, was detected for M2-macrophages, whereas the impact of nanotubes on M1-polarized macrophages was negligible. Importantly, we could confirm this phenotypic response on the fractal TiN surfaces. The results indicate that the investigated topographies specifically impact the macrophage M2-subtype that modulates the formation of the fibrotic capsule and the long-term response to an implant. Full article
(This article belongs to the Special Issue Biomedical Nanostructured Materials and Coatings)
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