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Special Issue "Synthesis, Characterization, and Biomedical and Pharmaceutical Applications of Ionic Liquids—In Memory of Professor Cinzia Chiappe"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Dr. Lorenzo Guazzelli
E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, Italy
Interests: ionic liquids; dicationic ionic liquids; biobased ionic liquids; deep eutectic solvents; physicochemical and antimicrobial properties

Special Issue Information

Dear Colleagues,

Ionic liquids have attracted an enormous deal of interest in the last twenty years thanks to their peculiar and yet tunable physicochemical properties. Indeed, ionic liquids have found application in a wide and very disparate range of applications. Although some research areas have reached a reasonable maturity level, others still appear in their infancy. One example of such underdeveloped arenas, albeit with immense potential, is represented by the use of ionic liquids in biomedical and pharmaceutical applications. Some exciting work (e.g., drug delivery systems, API-ILs, antimicrobial/anticancer agents) has been reported thus far, but it is indeed clear that further investigations will be crucial in defining the scope of ionic liquids in this area. Several different aspects still need to be understood in depth, and multidisciplinary approaches will be instrumental for the challenging task of identifying and designing optimal ionic liquids. The ultimate goal is no less than the development of future therapies, together with the implementation of platform systems endowed with beneficial properties, for human health.

Therefore, in this Special Issue, both novel ionic liquids as well as the relationship between properties and constitutive ions will be highlighted and discussed, with special emphasis on their potential to impact the biomedical sector.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Dr. Lorenzo Guazzelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ionic liquids
  • physicochemical properties
  • toxicity
  • biodegradability
  • drug delivery
  • API-ILs
  • antimicrobial properties
  • prodrugs
  • biotechnology
  • biomedical application
  • biomedical analytics
  • biosensor
  • ionogel
  • ionomics

Published Papers (2 papers)

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Research

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Article
Biodegradation of L-Valine Alkyl Ester Ibuprofenates by Bacterial Cultures
Materials 2021, 14(12), 3180; https://doi.org/10.3390/ma14123180 - 09 Jun 2021
Cited by 1 | Viewed by 597
Abstract
Nowadays, we consume very large amounts of medicinal substances. Medicines are used to cure, halt, or prevent disease, ease symptoms, or help in the diagnosis of illnesses. Some medications are used to treat pain. Ibuprofen is one of the most popular drugs in [...] Read more.
Nowadays, we consume very large amounts of medicinal substances. Medicines are used to cure, halt, or prevent disease, ease symptoms, or help in the diagnosis of illnesses. Some medications are used to treat pain. Ibuprofen is one of the most popular drugs in the world (it ranks third). This drug enters our water system through human pharmaceutical use. In this article, we describe and compare the biodegradation of ibuprofen and ibuprofen derivatives—salts of L-valine alkyl esters. Biodegradation studies of ibuprofen and its derivatives have been carried out with activated sludge. The structure modifications we received were aimed at increasing the biodegradation of the drug used. The influence of the alkyl chain length of the ester used in the biodegradation of the compound was also verified. The biodegradation results correlated with the lipophilic properties (log P). Full article
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Review

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Review
Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
Materials 2021, 14(21), 6231; https://doi.org/10.3390/ma14216231 - 20 Oct 2021
Viewed by 461
Abstract
The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly [...] Read more.
The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs’ aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided. Full article
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