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Advanced Materials for Bone Regeneration and Treatment

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 631

Special Issue Editors


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Guest Editor
1. School of Dentistry Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
2. Department of Metallurgical and Materials Engineering, The University of São Paulo, Sao Paulo, Brazil
Interests: osteoarthritis; cartilage repair; orthopaedic biologics; cell therapy; tissue engineering; orthopaedics; sports medicine
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Guest Editor
1. Center for Natural and Human Sciences, Federal University of ABC, Santo André, Brazil
2. School of Biomedical Engineering, Faculdade Israelita de Ciência das Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, State of São Paulo, Brazil
Interests: biomaterials; bioceramics; tissue engineering; bioactive glasses; magnetic hyperthermia; brachytherapy; cancer treatment; bone regeneration

Special Issue Information

Dear Colleagues,

This Special Issue of Materials focuses on cutting-edge advancements in Tissue Engineering Applied to Bone Regeneration and Treatment. Emphasizing the latest research, we seek to explore innovative strategies for bone regeneration, bone diseases, bone cancer, and bone infections using bioceramics, composites, and nanomaterials, as well as their integration with stem cells or 3D-printing technologies. We aim to provide a comprehensive overview of current methodologies and future directions in the field, highlighting both the potential and challenges of these technologies. Submissions of original articles and reviews are welcome, particularly those that offer new insights into the application of tissue engineering for bone regeneration and treatment. This issue promises to be an invaluable resource for researchers and practitioners dedicated to advancing bone health and therapeutic interventions.

Dr. Daniela Franco Bueno
Dr. Roger Borges
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • bone regeneration
  • bone diseases
  • 3d printing
  • bioceramics
  • composites
  • nanomaterials
  • stem cells
  • drug delivery

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Published Papers (1 paper)

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Research

14 pages, 2100 KiB  
Article
Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold with BMP-2 Protein in a Rabbit Model
by Giulio Edoardo Vigni, Mariano Licciardi, Lorenzo D’itri, Francesca Terracina, Sergio Scirè, Giuseppe Arrabito, Bruno Pignataro, Lawrence Camarda, Giovanni Cassata, Roberto Puleio, Lucio Di Silvestre and Luca Cicero
Materials 2025, 18(10), 2234; https://doi.org/10.3390/ma18102234 - 12 May 2025
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Abstract
Extensive bone loss represents a great challenge for orthopedic and reconstructive surgery. On an in vivo rabbit model, the healing of two bone defects on a long bone, tibia, was studied. A polybutylene succinate (PBS) microfibrillar scaffold was implemented with BMP-2 protein and [...] Read more.
Extensive bone loss represents a great challenge for orthopedic and reconstructive surgery. On an in vivo rabbit model, the healing of two bone defects on a long bone, tibia, was studied. A polybutylene succinate (PBS) microfibrillar scaffold was implemented with BMP-2 protein and hydroxyapatite (HA) as potential osteogenic factors. The present study was carried out on 6 male New Zealand white (4–6 months old) rabbits in vivo model. One bone defect was created in each subject on the tibia. The controls were left to heal spontaneously while the study samples were treated with the polybutylene succinate (PBS) microfibrillar scaffolds doped with BMP-2 and HA. Histological and immunohistochemical analyses were performed after euthanasia at 3 and 6 months. The bone defect treated with the BMP-2 PBS scaffold shows, from 3 months, a significantly increased presence of activated osteoblasts with mineralized bone tissue deposition. This study confirms the great potential of PBS scaffolds in the clinical treatment of bone defects. Full article
(This article belongs to the Special Issue Advanced Materials for Bone Regeneration and Treatment)
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