Cell- and Molecular-Mediated Drug Delivery for Bone and Cartilage Repair

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 566

Special Issue Editors


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Guest Editor
1. Sports Medicine Division, Institute of Orthopedics and Traumatology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil
2. Hospital Sírio Libanês, Sao Paulo, Brazil
Interests: bone defects; orthopaedic biologics; cell therapy; tissue engineering; dentistry; cleft lip and palate
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Guest Editor
1. School of Dentistry Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
2. Department of Metallurgical and Materials Engineering, The University of São Paulo, Sao Paulo, Brazil
Interests: osteoarthritis; cartilage repair; orthopaedic biologics; cell therapy; tissue engineering; orthopaedics; sports medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue on "Cell- and Molecular-Mediated Drug Delivery for Bone and Cartilage Repair".

Bone and cartilage injuries represent a significant clinical challenge, remaining a major hurdle in the effective treatment and improvement of patients' clinical outcomes.

Cellular and molecular approaches in drug delivery hold tremendous potential to enhance tissue repair, reduce side effects, and improve patient outcomes. Recent advancements in drug delivery systems have revolutionized treatment strategies, offering targeted, efficient, and sustained therapeutic effects.

We look forward to receiving your contributions.

Dr. Tiago Lazzaretti Fernandes
Dr. Daniela Franco Bueno
Guest Editors

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Keywords

  • drug delivery systems
  • drug discovery
  • bone repair
  • cartilage repair
  • molecular therapies
  • cellular approaches
  • tissue engineering
  • nanotechnology
  • stem cell therapy
  • biomaterials
  • osteoarthritis
  • therapy

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Published Papers (1 paper)

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Research

15 pages, 4708 KB  
Article
mRNA-Based Combination Therapy for Inflammation-Driven Osteoarthritis Induced by Monosodium Iodoacetate
by Yuki Terai, Erica Yada, Hideyuki Nakanishi and Keiji Itaka
Pharmaceutics 2025, 17(10), 1254; https://doi.org/10.3390/pharmaceutics17101254 - 24 Sep 2025
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Abstract
Background/Objectives: Osteoarthritis (OA) is a progressive joint disease characterized by inflammation, cartilage degradation, and subchondral bone changes, for which effective disease-modifying therapies are lacking. Messenger RNA (mRNA)-based therapeutics offer a versatile approach to modulate joint pathology, but their application to OA remains limited. [...] Read more.
Background/Objectives: Osteoarthritis (OA) is a progressive joint disease characterized by inflammation, cartilage degradation, and subchondral bone changes, for which effective disease-modifying therapies are lacking. Messenger RNA (mRNA)-based therapeutics offer a versatile approach to modulate joint pathology, but their application to OA remains limited. Methods: We evaluated intra-articular delivery of therapeutic mRNAs using polyplex nanomicelles, a non-inflammatory and minimally invasive carrier system, in a rat model of inflammation-driven OA induced by monosodium iodoacetate (MIA). Results: IL-1 receptor antagonist (IL-1Ra) mRNA reduced synovial inflammation and alleviated pain and swelling. RUNX1 mRNA, a transcription factor critical for chondrogenesis, supported chondrocyte viability, type II collagen expression, and cartilage structure. Under conditions of pronounced inflammation, however, the protective effects of RUNX1 mRNA alone were modest. Notably, combined administration of IL-1Ra and RUNX1 mRNAs produced synergistic therapeutic benefits, with enhanced chondroprotection and preservation of subchondral bone integrity. Conclusions: These findings suggest that while RUNX1 is essential for maintaining cartilage homeostasis, effective control of joint inflammation is required for its therapeutic activity. Dual mRNA therapy delivered by polyplex nanomicelles therefore represents a promising strategy to address the multifactorial pathology of OA. Full article
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