Submit to Marine Drugs Review for Marine Drugs Propose a Special Issue

Journal Menu

Journal Browser

► Journal Browser

Marine Fatty Acids-2016

Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Related Special Issue
Published Papers

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 January 2016) | Viewed by 134760

Share This Special Issue

Special Issue Editors

Dr. Andrew P. Desbois

E-Mail Website
Guest Editor

Institute of Aquaculture, University of Stirling, Stirling, Stirlingshire, FK9 4LA, UK
Interests: Discovery and development of antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Dr. Valerie Smith

E-Mail Website
Guest Editor

Scottish Oceans Institute, East Sands, University of St Andrews, St Andrews, Fife KY16 8LB, UK
Interests: marine microbiology and comparative immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In 2013, we issued a call for manuscript submissions to a special issue of Marine Drugs dedicated to marine fatty acids, Marine Fatty Acids-2013. This initial call resulted in the publication of 14 invited and offered manuscripts, including two review articles. The breadth of subject matter covered was considerable and included articles focusing on the in vitro and in vivo biological activities of marine-derived fatty acids and lipids (e.g., anti-viral, anti-microbial and anti-inflammatory properties), the clinical effects of dietary omega-3 fatty acid supplements, and further contributions devoted to fatty acid biosynthesis and lipid metabolism pathways of marine organisms. Following the success of the special issue in 2013, as Guest Editors we call again on researchers and scholars in the field to contribute manuscripts to be considered for inclusion in this second Marine Fatty Acids special issue of the journal. In particular, we welcome original research articles, comprehensive reviews and timely mini-reviews related to all aspects of marine fatty acids. Accepted manuscripts will be published Open Access.

Dr. Valerie J. Smith
Dr. Andrew P. Desbois
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Antimicrobial
eicosapentaenoic acid
glycolipid
lipids
marine chemical ecology
monounsaturated fatty acids
natural products
omega-3
phospholipid
polyunsaturated fatty acids
signalling

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Marine Fatty Acids-2013 in Marine Drugs (14 articles)

Published Papers (10 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

2105 KiB

Open AccessArticle

High-EPA Biomass from Nannochloropsis salina Cultivated in a Flat-Panel Photo-Bioreactor on a Process Water-Enriched Growth Medium

by Hamed Safafar, Michael Z. Hass, Per Møller, Susan L. Holdt and Charlotte Jacobsen

Mar. Drugs 2016, 14(8), 144; https://doi.org/10.3390/md14080144 - 29 Jul 2016

Cited by 51 | Viewed by 9726

Abstract

Nannochloropsis salina was grown on a mixture of standard growth media and pre-gasified industrial process water representing effluent from a local biogas plant. The study aimed to investigate the effects of enriched growth media and cultivation time on nutritional composition of Nannochloropsis salina biomass, with a focus on eicosapentaenoic acid (EPA). Variations in fatty acid composition, lipids, protein, amino acids, tocopherols and pigments were studied and results compared to algae cultivated on F/2 media as reference. Mixed growth media and process water enhanced the nutritional quality of Nannochloropsis salina in laboratory scale when compared to algae cultivated in standard F/2 medium. Data from laboratory scale translated to the large scale using a 4000 L flat panel photo-bioreactor system. The algae growth rate in winter conditions in Denmark was slow, but results revealed that large-scale cultivation of Nannochloropsis salina at these conditions could improve the nutritional properties such as EPA, tocopherol, protein and carotenoids compared to laboratory-scale cultivated microalgae. EPA reached 44.2% ± 2.30% of total fatty acids, and α-tocopherol reached 431 ± 28 µg/g of biomass dry weight after 21 days of cultivation. Variations in chemical compositions of Nannochloropsis salina were studied during the course of cultivation. Nannochloropsis salina can be presented as a good candidate for winter time cultivation in Denmark. The resulting biomass is a rich source of EPA and also a good source of protein (amino acids), tocopherols and carotenoids for potential use in aquaculture feed industry. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

414 KiB

Open AccessArticle

Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies

by Biljana Ilievska, Thorsteinn Loftsson, Martha Asdis Hjalmarsdottir and Gudrun Marta Asgrimsdottir

Mar. Drugs 2016, 14(6), 105; https://doi.org/10.3390/md14060105 - 1 Jun 2016

Cited by 17 | Viewed by 9394

Abstract

The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia. Therefore, free polyunsaturated fatty acids from cod liver oil or other fish oils can be used as safe and natural antibacterial agents. In this study, ointment compositions containing free fatty acids as active antibacterial agents were prepared by using various natural waxes and characterized. The effects of different waxes, such as carnauba wax, ozokerite wax, laurel wax, beeswax, rice bran wax, candelilla wax and microcrystalline wax, in the concentration range of 1% to 5% (w/w) on the ointment texture, consistency and stability were evaluated. The results showed significant variations in texture, sensory and rheological profiles. This was attributed to the wax’s nature and chain composition. Microcrystalline wax gave the best results but laurel wax, beeswax and rice bran wax exhibited excellent texturing, similar sensory profiles and well-balanced rheological properties. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

238 KiB

Open AccessArticle

Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast

by Flore Dagorn, Aurélie Couzinet-Mossion, Melha Kendel, Peter G. Beninger, Vony Rabesaotra, Gilles Barnathan and Gaëtane Wielgosz-Collin

Mar. Drugs 2016, 14(6), 104; https://doi.org/10.3390/md14060104 - 24 May 2016

Cited by 17 | Viewed by 6750

Abstract

Economic exploitation is one means to offset the cost of controlling invasive species, such as the introduced Pacific oyster (Crassostrea gigas Thunberg) on the French Atlantic coast. Total lipid and phospholipid (PL) fatty acids (FAs) and sterols were examined in an invasive population of C. gigas in Bourgneuf Bay, France, over four successive seasons, with a view to identify possible sources of exploitable substances. The total lipid level (% dry weight) varied from 7.1% (winter) to 8.6% (spring). Of this, PLs accounted for 28.1% (spring) to 50.4% (winter). Phosphatidylcholine was the dominant PL throughout the year (up to 74% of total PLs in winter). Plasmalogens were identified throughout the year as a series of eleven dimethylacetals (DMAs) with chain lengths between C₁₆ and C₂₀ (up to 14.5% of PL FAs + DMAs in winter). Thirty-seven FAs were identified in the PL FAs. Eicosapentaenoic acid (20:5n-3 EPA/7.53% to 14.5%) and docosahexaenoic acid (22:6n-3 DHA/5.51% to 9.5%) were the dominant polyunsaturated FAs in all seasons. Two non-methylene-interrupted dienoic (NMID) FAs were identified in all seasons: 7,13-docosadienoic and 7,15-docosadienoic acids, the latter being present at relatively high levels (up to 9.6% in winter). Twenty free sterols were identified, including cholesterol at 29.9% of the sterol mixture and about 33% of phytosterols. C. gigas tissues thus contained exploitable lipids for health benefits or as a potential source of high-quality commercial lecithin. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

2244 KiB

Open AccessArticle

Comparative Studies on the Characteristic Fatty Acid Profiles of Four Different Chinese Medicinal Sargassum Seaweeds by GC-MS and Chemometrics

by Zhen Chen, Yibing Xu, Tao Liu, Lining Zhang, Hongbing Liu and Huashi Guan

Mar. Drugs 2016, 14(4), 68; https://doi.org/10.3390/md14040068 - 29 Mar 2016

Cited by 26 | Viewed by 8253

Abstract

Sargassum seaweeds produce abundant biomass in China and have long been used as herbal medicine and food. Their characteristic fatty acid (FA) profiles and related potential function in promoting cardiovascular health (CVH) have not been systematically investigated. In this study, FA profiles of four medicinal Sargassum were characterized using GC-MS. Principal component analysis was used to discriminate the four medicinal Sargassum, and orthogonal projection to latent structures discriminant analysis was carried out between the two official species HAI ZAO and between the two folk medicine species HAI QIAN. In all of the algae investigated, the major SFA and MUFA were palmitic and stearic acid, respectively, while the major PUFAs were linoleic, arachidonic, and eicosapentaenoic acid. S. fusiforme and S. horneri had higher concentrations of PUFAs. With respect to CVH, all of the studied species, particularly S. fusiforme, exhibited satisfactory levels such as PUFA/SFA ratio and n-6/n-3 ratio. Each species possesses a unique FA profile and is discriminated clearly. Potential key FA markers (between the two Chinese official species, and between the two folk species) are assessed. The study provides characteristic fatty acid profiles of four Chinese medicinal Sargassum and their related potential function in promoting CVH. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

926 KiB

Open AccessFeature PaperArticle

Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum

by Mary L. Hamilton, Stephen Powers, Johnathan A. Napier and Olga Sayanova

Mar. Drugs 2016, 14(3), 53; https://doi.org/10.3390/md14030053 - 9 Mar 2016

Cited by 80 | Viewed by 8953

Abstract

We have created via metabolic engineering a heterotrophic strain of Phaeodactylum tricornutum that accumulates enhanced levels of the high value omega-3 long chain polyunsaturated fatty acid (LC-PUFAs) docosahexaenoic acid (DHA). This was achieved by generation of transgenic strains in which the Δ5-elongase from Ostreococcus tauri was co-expressed with a glucose transporter from the moss Physcomitrella patens. This double transformant has the capacity to grow in the dark in liquid medium supplemented with glucose and accumulate substantial levels of omega-3 LC-PUFAs. The effects of glucose concentrations on growth and LC-PUFA production of wild type and transformed strains cultivated in the light and dark were studied. The highest omega-3 LC-PUFAs accumulation was observed in cultures grown under mixotrophic conditions in the presence of 1% glucose (up to 32.2% of total fatty acids, TFA). Both DHA and EPA are detected at high levels in the neutral lipids of transgenic cells grown under phototrophic conditions, averaging 36.5% and 23.6% of TFA, respectively. This study demonstrates the potential for P. tricornutum to be developed as a viable commercial strain for both EPA and DHA production under mixo- and heterotrophic conditions. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

Review

Jump to: Research

2236 KiB

Open AccessReview

Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids

by Elisabete Da Costa, Joana Silva, Sofia Hoffman Mendonça, Maria Helena Abreu and Maria Rosário Domingues

Mar. Drugs 2016, 14(5), 101; https://doi.org/10.3390/md14050101 - 19 May 2016

Cited by 96 | Viewed by 13719

Abstract

In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated fatty acids (PUFAs) like n-3 α-linolenic (ALA 18:3), eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6). GLs comprise three major classes: monogalactosyldiacyl glycerolipids (MGDGs), digalactosyl diacylglycerolipids (DGDGs) and sulfoquinovosyl diacylglycerolipids (SQDGs), whose composition in FA directly depends on the growth conditions. Some of these lipids are high value-added compounds with antitumoral, antimicrobial and anti-inflammatory activities and also with important nutritional significance. To fully explore GLs’ bioactive properties it is necessary to fully characterize their structure and to understand the relation between the structure and their biological properties, which can be addressed using modern mass spectrometry (MS)-based lipidomic approaches. This review will focus on the up-to-date FA composition of GLs identified by MS-based lipidomics and their potential as phytochemicals. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

2107 KiB

Open AccessFeature PaperReview

Bacterial Long-Chain Polyunsaturated Fatty Acids: Their Biosynthetic Genes, Functions, and Practical Use

by Kiyohito Yoshida, Mikako Hashimoto, Ryuji Hori, Takumi Adachi, Hidetoshi Okuyama, Yoshitake Orikasa, Tadashi Nagamine, Satoru Shimizu, Akio Ueno and Naoki Morita

Mar. Drugs 2016, 14(5), 94; https://doi.org/10.3390/md14050094 - 12 May 2016

Cited by 87 | Viewed by 14712

Abstract

The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic mechanisms and functions of LC-PUFAs in bacteria compared to those in higher organisms, a combination of genetic, bioinformatic, and molecular biological approaches to LC-PUFA-producing bacteria and some eukaryotes have revealed the notably diverse organization of the pfa genes encoding a polyunsaturated fatty acid synthase complex (PUFA synthase), the LC-PUFA biosynthetic processes, and tertiary structures of the domains of this enzyme. In bacteria, LC-PUFAs appear to take part in specific functions facilitating individual membrane proteins rather than in the adjustment of the physical fluidity of the whole cell membrane. Very long chain polyunsaturated hydrocarbons (LC-HCs) such as hentriacontanonaene are considered to be closely related to LC-PUFAs in their biosynthesis and function. The possible role of LC-HCs in strictly anaerobic bacteria under aerobic and anaerobic environments and the evolutionary relationships of anaerobic and aerobic bacteria carrying pfa-like genes are also discussed. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

1919 KiB

Open AccessReview

Lipid Production from Nannochloropsis

by Xiao-Nian Ma, Tian-Peng Chen, Bo Yang, Jin Liu and Feng Chen

Mar. Drugs 2016, 14(4), 61; https://doi.org/10.3390/md14040061 - 25 Mar 2016

Cited by 258 | Viewed by 19768

Abstract

Microalgae are sunlight-driven green cell factories for the production of potential bioactive products and biofuels. Nannochloropsis represents a genus of marine microalgae with high photosynthetic efficiency and can convert carbon dioxide to storage lipids mainly in the form of triacylglycerols and to the ω-3 long-chain polyunsaturated fatty acid eicosapentaenoic acid (EPA). Recently, Nannochloropsis has received ever-increasing interests of both research and public communities. This review aims to provide an overview of biology and biotechnological potential of Nannochloropsis, with the emphasis on lipid production. The path forward for the further exploration of Nannochloropsis for lipid production with respect to both challenges and opportunities is also discussed. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

4493 KiB

Open AccessReview

Biologically Active Oxylipins from Enzymatic and Nonenzymatic Routes in Macroalgae

by Mariana Barbosa, Patrícia Valentão and Paula B. Andrade

Mar. Drugs 2016, 14(1), 23; https://doi.org/10.3390/md14010023 - 20 Jan 2016

Cited by 69 | Viewed by 8728

Abstract

Marine algae are rich and heterogeneous sources of great chemical diversity, among which oxylipins are a well-recognized class of natural products. Algal oxylipins comprise an assortment of oxygenated, halogenated, and unsaturated functional groups and also several carbocycles, varying in ring size and position in lipid chain. Besides the discovery of structurally diverse oxylipins in macroalgae, research has recently deciphered the role of some of these metabolites in the defense and innate immunity of photosynthetic marine organisms. This review is an attempt to comprehensively cover the available literature on the chemistry, biosynthesis, ecology, and potential bioactivity of oxylipins from marine macroalgae. For a better understanding, enzymatic and nonenzymatic routes were separated; however, both processes often occur concomitantly and may influence each other, even producing structurally related molecules. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Graphical abstract

1048 KiB

Open AccessReview

Omega-3 Fatty Acids and Skeletal Muscle Health

by Stewart Jeromson, Iain J. Gallagher, Stuart D. R. Galloway and D. Lee Hamilton

Mar. Drugs 2015, 13(11), 6977-7004; https://doi.org/10.3390/md13116977 - 19 Nov 2015

Cited by 143 | Viewed by 33940

Abstract

Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be modified by the prior nutritional status of the muscle. The influence of nutrition on skeletal muscle has the potential to substantially impact physical function and whole body metabolism. Animal and cell based models show that omega-3 fatty acids, in particular those of marine origin, can influence skeletal muscle metabolism. Furthermore, recent human studies demonstrate that omega-3 fatty acids of marine origin can influence the exercise and nutritional response of skeletal muscle. These studies show that the prior omega-3 status influences not only the metabolic response of muscle to nutrition, but also the functional response to a period of exercise training. Omega-3 fatty acids of marine origin therefore have the potential to alter the trajectory of a number of human diseases including the physical decline associated with aging. We explore the potential molecular mechanisms by which omega-3 fatty acids may act in skeletal muscle, considering the n-3/n-6 ratio, inflammation and lipidomic remodelling as possible mechanisms of action. Finally, we suggest some avenues for further research to clarify how omega-3 fatty acids may be exerting their biological action in skeletal muscle. Full article

(This article belongs to the Special Issue Marine Fatty Acids-2016)

► Show Figures

Journal Menu

Journal Browser

Marine Fatty Acids-2016

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Related Special Issue

Published Papers (10 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI