Special Issue "Bioactive Compounds from Marine Sediment Derived Fungi"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 15 February 2022.

Special Issue Editor

Dr. Ekaterina Yurchenko
E-Mail Website
Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation
Interests: bioactive compounds; secondary metabolites; marine invertebrates; marine fungi; cytoprotection; cytotoxicity, structure-activity relationships
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Special Issue Information

Dear Colleagues,

Marine sediments reflect the extreme marine environmental conditions of sea waters as well as coastal areas. A wide variety of inhabitants of marine sediments makes this ecosystem highly competitive, which affects the metabolism of organisms. Marine-sediment-derived microfilamentous fungi are able to produce many low-molecular-weight secondary metabolites to adapt to such conditions. Over the past decade, interest in the study of secondary metabolites of marine-sediment-derived fungi has been steadily growing: from 10–15 papers (30–50 new compounds) in 2009–2010 to more than 30 articles (120–140 new metabolites) in the past two years. The most diverse structural types of substances and various types of biological activity of marine lead molecules and drugs are the result of a chemical study of microfilamentous fungi metabolomes. The newest technological advances in methods for isolating and identifying compounds now make it possible to detect minor individual compounds from marin- sediment-derived fungi as well as to study these metabolome.

Thus, chemical diversity investigation of marine-sediment-derived fungi is one of the most dynamically developing fields of marine natural products chemistry. As the Guest Editor of this Special Issue of Marine Drugs, I invite you to contribute papers describing isolation and identification of individual compounds from marine-sediment-derived fungi as well as studying these biological activities. Moreover, manuscripts describing metabolomic investigation of marine-sediment-derived fungi are also welcome.

Dr. Ekaterina Yurchenko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine sediments
  • fungi
  • natural products
  • biologically active compounds
  • metabolome
  • secondary metabolites

Published Papers (6 papers)

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Research

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Article
Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage
Mar. Drugs 2021, 19(10), 553; https://doi.org/10.3390/md19100553 - 29 Sep 2021
Viewed by 272
Abstract
Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the skin and mucosal surfaces. Staphylococcus aureus infection can develop, not only from minor scratches of the skin, but this pathogen can also actively promote [...] Read more.
Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the skin and mucosal surfaces. Staphylococcus aureus infection can develop, not only from minor scratches of the skin, but this pathogen can also actively promote epithelial breach. The effect of cerebroside flavuside B from marine sediment-derived fungus Penicillium islandicum (Aniva Bay, the Sea of Okhotsk) on viability, apoptosis, total caspase activity, and cell cycle in human epidermal keratinocytes HaCaT line co-cultivated with S. aureus, as well as influence of flavuside B on LPS-treated HaCaT cells were studied. Influence of flavuside B on bacterial growth and biofilm formation of S. aureus and its effect on the enzymatic activity of sortase A was also investigated. It was found S. aureus co-cultivated with keratinocytes induces caspase-depended apoptosis and cell death, arrest cell cycle in the G0/G1 phase, and increases in cellular immune inflammation. Cerebroside flavuside B has demonstrated its antimicrobial and anti-inflammatory properties, substantially eliminating all the negative consequences caused by co-cultivation of keratinocytes with S. aureus or bacterial LPS. The dual action of flavuside B may be highly effective in the treatment of bacterial skin lesions and will be studied in the future in in vivo experiments. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Article
Structurally Diverse Polycyclic Salicylaldehyde Derivative Enantiomers from a Marine-Derived Fungus Eurotium sp. SCSIO F452
Mar. Drugs 2021, 19(10), 543; https://doi.org/10.3390/md19100543 - 26 Sep 2021
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Abstract
To enlarge the chemical diversity of Eurotium sp. SCSIO F452, a talented marine-derived fungus, we further investigated its chemical constituents from a large-scale fermentation with modified culture. Four pairs of new salicylaldehyde derivative enantiomers, euroticins F-I (14), as well [...] Read more.
To enlarge the chemical diversity of Eurotium sp. SCSIO F452, a talented marine-derived fungus, we further investigated its chemical constituents from a large-scale fermentation with modified culture. Four pairs of new salicylaldehyde derivative enantiomers, euroticins F-I (14), as well as a known one eurotirumin (5) were isolated and characterized. Compound 1 features an unprecedented constructed 6/6/6/5 tetracyclic structures, while 2 and 3 represent two new types of 6/6/5 scaffolds. Their structures were established by comprehensive spectroscopic analyses, X-ray diffraction, 13C NMR, and electronic circular dichroism calculations. Selected compounds showed significant inhibitory activity against α-glucosidase and moderate cytotoxic activities against SF-268, MCF-7, HepG2, and A549 cell lines. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Article
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera
Mar. Drugs 2020, 18(12), 608; https://doi.org/10.3390/md18120608 - 30 Nov 2020
Cited by 2 | Viewed by 891
Abstract
Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds [...] Read more.
Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Article
Hatsusamides A and B: Two New Metabolites Produced by the Deep-Sea-Derived Fungal Strain Penicillium steckii FKJ-0213
Mar. Drugs 2020, 18(10), 513; https://doi.org/10.3390/md18100513 - 12 Oct 2020
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Abstract
Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by [...] Read more.
Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic acid B-trichodermamide C hybrid structure and a new analog of aspergillazines, respectively. The absolute configuration of 1 was determined by comparing the values of tanzawaic acid B and trichodermamide C in the literatures, such as 1H-nuclear magnetic resonance (1H-NMR) data and optical rotation, after hydrolysis of 1. Compounds 14 were evaluated for cytotoxicity and anti-malarial activities. Compounds 1 and 3 exhibited weak anti-malarial activity at half-maximal inhibitory concentration (IC50) values of 27.2 and 78.5 µM against the K1 strain, and 27.9 and 79.2 µM against the FCR3 strain of Plasmodium falciparum, respectively. Furthermore, 1 exhibited cytotoxicity against HeLa S3, A549, Panc1, HT29 and H1299 cells, with IC50 values of 15.0, 13.7, 12.9, 6.8, and 18.7 μM, respectively. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Article
Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429
Mar. Drugs 2020, 18(8), 381; https://doi.org/10.3390/md18080381 - 23 Jul 2020
Viewed by 852
Abstract
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues [...] Read more.
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Review

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Review
Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies
Mar. Drugs 2021, 19(2), 88; https://doi.org/10.3390/md19020088 - 04 Feb 2021
Cited by 1 | Viewed by 848
Abstract
Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their [...] Read more.
Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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