Special Issue "Bioactive Compounds from Marine Sediment Derived Fungi"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Dr. Ekaterina Yurchenko
Website
Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences, Vladivostok, Russian Federation
Interests: bioactive compounds; secondary metabolites; marine invertebrates; marine fungi; cytoprotection; cytotoxicity, structure-activity relationships
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Special Issue Information

Dear Colleagues,

Marine sediments reflect the extreme marine environmental conditions of sea waters as well as coastal areas. A wide variety of inhabitants of marine sediments makes this ecosystem highly competitive, which affects the metabolism of organisms. Marine-sediment-derived microfilamentous fungi are able to produce many low-molecular-weight secondary metabolites to adapt to such conditions. Over the past decade, interest in the study of secondary metabolites of marine-sediment-derived fungi has been steadily growing: from 10–15 papers (30–50 new compounds) in 2009–2010 to more than 30 articles (120–140 new metabolites) in the past two years. The most diverse structural types of substances and various types of biological activity of marine lead molecules and drugs are the result of a chemical study of microfilamentous fungi metabolomes. The newest technological advances in methods for isolating and identifying compounds now make it possible to detect minor individual compounds from marin- sediment-derived fungi as well as to study these metabolome.

Thus, chemical diversity investigation of marine-sediment-derived fungi is one of the most dynamically developing fields of marine natural products chemistry. As the Guest Editor of this Special Issue of Marine Drugs, I invite you to contribute papers describing isolation and identification of individual compounds from marine-sediment-derived fungi as well as studying these biological activities. Moreover, manuscripts describing metabolomic investigation of marine-sediment-derived fungi are also welcome.

Dr. Ekaterina Yurchenko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine sediments
  • fungi
  • natural products
  • biologically active compounds
  • metabolome
  • secondary metabolites

Published Papers (2 papers)

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Research

Open AccessArticle
Hatsusamides A and B: Two New Metabolites Produced by the Deep-Sea-Derived Fungal Strain Penicillium steckii FKJ-0213
Mar. Drugs 2020, 18(10), 513; https://doi.org/10.3390/md18100513 - 12 Oct 2020
Abstract
Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by [...] Read more.
Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic acid B-trichodermamide C hybrid structure and a new analog of aspergillazines, respectively. The absolute configuration of 1 was determined by comparing the values of tanzawaic acid B and trichodermamide C in the literatures, such as 1H-nuclear magnetic resonance (1H-NMR) data and optical rotation, after hydrolysis of 1. Compounds 14 were evaluated for cytotoxicity and anti-malarial activities. Compounds 1 and 3 exhibited weak anti-malarial activity at half-maximal inhibitory concentration (IC50) values of 27.2 and 78.5 µM against the K1 strain, and 27.9 and 79.2 µM against the FCR3 strain of Plasmodium falciparum, respectively. Furthermore, 1 exhibited cytotoxicity against HeLa S3, A549, Panc1, HT29 and H1299 cells, with IC50 values of 15.0, 13.7, 12.9, 6.8, and 18.7 μM, respectively. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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Open AccessArticle
Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429
Mar. Drugs 2020, 18(8), 381; https://doi.org/10.3390/md18080381 - 23 Jul 2020
Abstract
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues [...] Read more.
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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