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Open AccessArticle

Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China
2
School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(8), 381; https://doi.org/10.3390/md18080381
Received: 6 July 2020 / Revised: 21 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
The chemical investigation of a methanol extract of the deep-sea-derived fungus Diaporthe longicolla FS429 led to the isolation of two novel diterpenoids longidiacids A and B (1 and 2), two new polyketides (3 and 4), two new cytochalasin analogues longichalasins A and B (6 and 8) and three known analogues 5, 7, 9. Their structures were elucidated through comprehensive spectroscopic analysis, while the absolute configurations were established by the comparison of the experimental and quantum chemical calculated ECD spectra. The structure of compound 7 was confirmed through X-ray diffraction for the first time. In the bioassays compound 8 exhibited antiproliferative effects against SF-268, with an IC50 value of 16.44 μM. Moreover, compounds 1 and 8 were detected to inhibit 35.4% and 53.5% of enzyme activity of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) at a concentration of 50 μM. View Full-Text
Keywords: bioactive metabolites; deep-sea derived-fungus; Diaporthe longicolla; bioactivities bioactive metabolites; deep-sea derived-fungus; Diaporthe longicolla; bioactivities
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MDPI and ACS Style

Liu, Z.; Chen, Y.; Li, S.; Wang, Q.; Hu, C.; Liu, H.; Zhang, W. Bioactive Metabolites from the Deep-Sea-Derived Fungus Diaporthe longicolla FS429. Mar. Drugs 2020, 18, 381.

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