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Bioactive Substances from Marine Sediments, Invertebrates and Algae Derived Fungi

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A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 8690

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Special Issue Editor

Dr. Ekaterina Yurchenko

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Guest Editor

G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences, Vladivostok, Russia
Interests: bioactive compounds; secondary metabolites; marine invertebrates; marine fungi; cytoprotection; cytotoxicity; structure–activity relationships
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The intensive study of marine fungi as producers of biologically active compounds began in the early 2000s. As a result, about 8,000 new metabolites from marine fungi have been described to date, and the richest sources of them are marine sediments, invertebrates, and algae.

In marine sediments, marine fungi are in a competitive relationship with prokaryotes, which causes them to produce secondary metabolites not only with antibacterial and cytotoxic activity, but also with antioxidant and anti-inflammatory properties. The discovery in invertebrate-associated fungi of compounds similar in structure and activity to substances isolated from invertebrates raises the question of the level of relationships between sponges, holothurians, corals and their fungal symbionts. Fungi isolated from the surface or from the thallus of algae are also of particular interest. The most diverse structural types of substances and various types of biological activity of molecules are the result of a chemical study of the metabolomes of microfilamentous fungi. The latest technological advances in compound isolation and identification methods now allow the detection of minor individual compounds from marine fungi as well as the study of their metabolome.

This Special Issue of Marine Drugs invites the submission of articles that address the isolation and identification of individual compounds from fungi derived from marine sediments, invertebrates and algae, and the study of their biological activity. In addition, manuscripts that describe the metabolic studies of these fungi are welcome.

Dr. Ekaterina Yurchenko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

marine fungi
sediments
invertebrates
algae
natural compounds
secondary metabolites
biological activity

Related Special Issue

Bioactive Compounds from Marine Sediment Derived Fungi in Marine Drugs (10 articles)

Published Papers (4 papers)

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Research

13 pages, 21278 KiB

Open AccessArticle

Mechanisms of Antitumor Invasion and Metastasis of the Marine Fungal Derivative Epi-Aszonalenin A in HT1080 Cells

by Yi Liu, Liyuan Lin, Haiyan Zheng, Yuan-Lin He, Yanmei Li, Chunxia Zhou, Pengzhi Hong, Shengli Sun, Yi Zhang and Zhong-Ji Qian

Mar. Drugs 2023, 21(3), 156; https://doi.org/10.3390/md21030156 - 26 Feb 2023

Cited by 1 | Viewed by 1667

Abstract

Epi-aszonalenin A (EAA) is an alkaloid that is isolated and purified from the secondary metabolites of coral symbiotic fungi and has been shown to have good atherosclerotic intervention activity and anti-angiogenic activity in our previous studies. In the present study, antiangiogenic activity was used as a basis of an intensive study of its mechanism of action against tumor metastasis and invasion. Invasive metastatic pairs are a hallmark of malignancy, and the dissemination of tumor cells is the most dangerous process in the development of tumors. The results of cell wound healing and the Transwell chamber assay showed that EAA interfered well with PMA-induced migration and invasion of HT1080 cells. Western blot and the ELISA assay showed that EAA decreased MMPs and vascular endothelial growth factor (VEGF) activity and inhibited the expression of N-cadherin and hypoxia-inducible factor-1α (HIF-1α) by regulating the phosphorylation of downstream mitogen-activated protein kinase (MAPK), PI3K/AKT, and NF-κB pathways. Simultaneous molecular docking results revealed that the mimic coupling between the EAA and MMP-2/-9 molecules formed a stable interaction. The results of this study provide a research basis for the inhibition of tumor metastasis by EAA, and together with previous studies, confirm the potential pharmacology and drug potential for this class of compound for application in angiogenesis-related diseases and further improve the availability of coral symbiotic fungi. Full article

(This article belongs to the Special Issue Bioactive Substances from Marine Sediments, Invertebrates and Algae Derived Fungi)

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11 pages, 1996 KiB

Open AccessArticle

Equisetin Targets Intracellular Staphylococcus aureus through a Host Acting Strategy

by Jiayao Tian, Shang Chen, Fei Liu, Qian Zhu, Jianzhong Shen, Wenhan Lin and Kui Zhu

Mar. Drugs 2022, 20(11), 656; https://doi.org/10.3390/md20110656 - 22 Oct 2022

Cited by 4 | Viewed by 2030

Abstract

Mammalian cells act as reservoirs of internalized bacteria to circumvent extracellular antibacterial compounds, resulting in relapse and reinfection diseases. The intracellular persistence of Staphylococcus aureus renders most traditional antibiotics useless, due to their inadequate subcellular accumulation. To replenish our antibiotic arsenal, we found that a marine-derived compound, equisetin, efficiently eliminates intracellular S. aureus by potentiating the host autophagy and inducing mitochondrial-mediated ROS generation to clear the invading S. aureus. The remarkable anti-infection activity of equisetin was validated in a peritonitis-infected mouse model. The marine product equisetin utilizes a unique dual mechanism to modulate the host–pathogen interaction in the clearance of intracellular bacteria. Thus, equisetin is an inspiring host-acting candidate for overcoming intracellular pathogens. Full article

(This article belongs to the Special Issue Bioactive Substances from Marine Sediments, Invertebrates and Algae Derived Fungi)

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17 pages, 2969 KiB

Open AccessArticle

Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639

by Olesya I. Zhuravleva, Elena B. Belousova, Galina K. Oleinikova, Alexandr S. Antonov, Yuliya V. Khudyakova, Anton B. Rasin, Roman S. Popov, Ekaterina S. Menchinskaya, Phan Thi Hoai Trinh, Anton N. Yurchenko and Ekaterina A. Yurchenko

Mar. Drugs 2022, 20(9), 584; https://doi.org/10.3390/md20090584 - 19 Sep 2022

Cited by 9 | Viewed by 2063

Abstract

Chemical investigation of a coculture of the marine-derived fungi Beauveria felina KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of three new drimane-type sesquiterpenes, asperflavinoids B, D and E (2, 4, 5), and nine previously reported related compounds. The structures of these compounds were established using spectroscopic methods and by comparison with known analogues. We also investigated the cytotoxic activity of the isolated compounds against several cancer and normal cell lines. Asperflavinoid C (3) and ustusolate E (9) exerted a significant effect on human breast cancer MCF-7 cell viability, with IC₅₀ values of 10 µM, and induced in caspase-dependent apoptosis and arrest of the MCF-7 cell cycle in the G2/M phase in these cells. Full article

(This article belongs to the Special Issue Bioactive Substances from Marine Sediments, Invertebrates and Algae Derived Fungi)

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12 pages, 2721 KiB

Open AccessArticle

Identification of PKS-NRPS Hybrid Metabolites in Marine-Derived Penicillium oxalicum

by Hongcheng Li, Wei Zhang, Xuan Zhang, Shen Tang, Ping Men, Mengyi Xiong, Zhimin Li, Yongyu Zhang, Xuenian Huang and Xuefeng Lu

Mar. Drugs 2022, 20(8), 523; https://doi.org/10.3390/md20080523 - 16 Aug 2022

Cited by 2 | Viewed by 2335

Abstract

Filamentous fungi are abundant resources of bioactive natural products. Here, 151 marine-derived fungi were collected from the north Yellow Sea and identified by an internal transcribed spacer (ITS) sequence. The crude extracts of all strains were evaluated for their antimicrobial activities and analyzed by HPLC fingerprint. Based on these, strain Penicillium oxalicum MEFC104 was selected for further investigation. Two new polyketide–amino acid hybrid compounds with feature structures of tetramic acid, oxopyrrolidine A and B, were isolated. Their planner structures were assigned by HRESIMS and 1D/2D NMR experiments. The absolute configurations were determined by modified Mosher’s method, J-based configuration analysis, and ECD calculations. Furthermore, the biosynthetic pathway was identified by bioinformatic analysis and gene-deletion experiments. This study established a link between oxopyrrolidines and the corresponding biosynthesis genes in P. oxalicum. Full article

(This article belongs to the Special Issue Bioactive Substances from Marine Sediments, Invertebrates and Algae Derived Fungi)

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