Marine Bioactive Compound Discovery through OSMAC Approach
A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 12707
Special Issue Editor
Special Issue Information
Dear Colleagues,
Marine microorganisms have proven to be a source of novel natural products with variety biological activities. However, because of the limitations of the traditional natural product mining methods, the number of gene clusters potentially encoding the production of natural products and the actual number of chemically characterized metabolites for a given microorganism are widely different.
In recent years, with the rapid development of gene sequencing technology and bioinformatics, cryptic metabolic pathways can be accessed using molecular techniques or cultivation-based approaches. The OSMAC approach (one strain—many compounds), based on modification of growth conditions, has proven to be a powerful strategy for the discovery of new cryptic natural products. The addition of chemical elicitors or epigenetic modifiers have also been used to activate silent genes.
This Special Issue invites articles from both molecular techniques or cultivation-based approaches on marine microorganisms with a focus on natural product discovery and characterization. We particularly welcome articles that combine genomic, metabolomic, and epigenetic approaches with OSMAC for the characterization of marine microorganism secondary metabolites.
Dr. Xiaoling Lu
Guest Editor
Manuscript Submission Information
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Keywords
- marine microorganisms
- secondary metabolites
- OSMAC
- epigenetic
- cryptic
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