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Bioprospecting of Marine Halophyte Plants

A Special Issue of Marine Drugs (ISSN 1660-3397) belonging to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 20 January 2027 | Viewed by 3872

Editors

Special Issue Information

Dear Colleagues,

Marine halophyte plants are a distinct group of salt-tolerant species capable of growing and completing their life cycle in environments characterized by high salinity, periodic flooding, intense radiation and oxidative stress, such as salt marshes, coastal dunes, tidal flats and saline wetlands. Depending on the species, halophytes can tolerate sodium chloride (NaCl) concentrations ranging from moderate salinity to levels comparable to or exceeding seawater (~600 mM), with some extreme halophytes reported to survive concentrations approaching 800–1000 mM NaCl under controlled conditions. These extreme environments drive the evolution of specialized physiological and metabolic adaptations, resulting in unique chemical diversity.

This Special Issue of Marine Drugs, entitled “Bioprospecting of Marine Halophyte Plants”, invites original research articles and reviews focused on marine and coastal halophytes as sources of bioactive natural products with pharmaceutical and nutraceutical relevance. Submissions are particularly encouraged in the following core topics:

  • Isolation, identification and structural characterization of natural products from marine halophyte plants
  • Phytochemical profiling and metabolomics of halophytes under saline and environmental stress
  • Biological activities relevant to human health, including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, anticancer and metabolic effects
  • Molecular and cellular mechanisms of action of halophyte-derived bioactive compounds
  • Influence of salinity and environmental stressors on secondary metabolite production and bioactivity
  • Ethnopharmacological knowledge and its experimental validation
  • Role of plant-associated microbiota (e.g., endophytic fungi and bacteria) in modulating halophyte metabolite production and bioactivity
  • Biotechnological approaches supporting the discovery, production and sustainable exploitation of halophyte-derived bioactive compounds

By integrating advanced analytical techniques, functional bioassays and mechanistic studies, this Special Issue aims to consolidate marine halophyte plants as a relevant and still underexplored source of marine-derived bioactive compounds, fostering innovation in drug discovery.

Dr. Luísa Custódio
Dr. Maria João Rodrigues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • natural products
  • secondary metabolites
  • phytochemistry
  • metabolomics
  • stress-induced metabolism
  • antioxidant activity
  • neuroprotective effects
  • blue biotechnology

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Published Papers (2 papers)

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Research

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26 pages, 6877 KB  
Article
Schoenoplectus californicus (C.A. Mey.) Soják: Chemical Profile, Antioxidant Capacity, Psychopharmacological Exploration and Analgesic Activity
by Julio Campos-Florián, Gladys Galliani-Huamanchumo, Alessandra Victoria Campos-Bazán, Betsabé Chunga-Flores, Inés Castro-Dionicio, Víctor E. Villarreal-La Torre, Lucia Fátima Flores-Atoche, Lucia Gonzales-Mendez, Gianfranco Ramos-Farfán, José Condor-Goytizolo, Ana María Guevara-Vásquez, Marilú Roxana Soto-Vásquez, Juan Carlos Rodríguez-Soto, Paul Alan Arkin Alvarado-García, William Sagástegui-Guarniz and Billy Cabanillas-Amado
Mar. Drugs 2026, 24(5), 160; https://doi.org/10.3390/md24050160 - 30 Apr 2026
Cited by 1 | Viewed by 2579
Abstract
Schoenoplectus californicus, a macrophyte from Peruvian marine–coastal wetlands, is traditionally used for medicinal purposes, yet its pharmacological potential remains insufficiently explored. This study evaluated the chemical profile, antioxidant capacity, psychopharmacological effects, and analgesic activity of a hydroethanolic extract from its rhizomes. Phytochemical [...] Read more.
Schoenoplectus californicus, a macrophyte from Peruvian marine–coastal wetlands, is traditionally used for medicinal purposes, yet its pharmacological potential remains insufficiently explored. This study evaluated the chemical profile, antioxidant capacity, psychopharmacological effects, and analgesic activity of a hydroethanolic extract from its rhizomes. Phytochemical screening and LC–MS/MS analyses were performed to characterize secondary metabolites. Antioxidant activity was assessed using DPPH and ABTS assays, while in vivo anxiolytic, sedative, and analgesic effects were evaluated in Balb/c mice through open field, elevated plus maze, rotarod, analgesimeter, tail-flick, and hot plate tests, with diazepam and tramadol as reference drugs. In silico PASS and BOILED-Egg analyses were used to predict pharmacological mechanisms and central nervous system permeability. The extract contained flavonoids, phenolic compounds, and stilbenes and exhibited notable antioxidant activity (IC50: 0.7319 mg/mL for DPPH and 0.6207 mg/mL for ABTS). Anxiolytic effects were observed at 50 mg/kg, sedative effects at 200 mg/kg, and significant analgesic activity at 50 mg/kg. Several compounds were predicted to cross the blood–brain barrier, with inhibition of GABA aminotransferase suggested as a potential mechanism. Acute toxicity was detected (LD50 > 2000 mg/kg). These findings support S. californicus as a promising source of neuroactive and analgesic compounds, although further mechanistic and dose-optimization studies are required. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Halophyte Plants)
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Review

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44 pages, 1560 KB  
Review
Ethnomedicinal Uses, Phytochemistry and Bioactivities of Halophytes and Salt-Tolerant Plants with Potential Against Metabolic Syndrome: A Comprehensive Review
by Maria João Rodrigues, Pedro García-Caparrós, Catarina Guerreiro Pereira, Christian Magné, Karim Ben Hamed, Mariana Laundry de Mesquita and Luísa Custódio
Mar. Drugs 2026, 24(8), 262; https://doi.org/10.3390/md24080262 - 29 Jul 2026
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Abstract
Metabolic syndrome (MetS) is a complex cluster of interconnected metabolic abnormalities, including central obesity, insulin resistance, dyslipidemia, hypertension, chronic inflammation, and impaired glucose metabolism, which collectively increase the risk of type 2 diabetes and cardiovascular diseases. Although current therapeutic strategies, including lifestyle interventions [...] Read more.
Metabolic syndrome (MetS) is a complex cluster of interconnected metabolic abnormalities, including central obesity, insulin resistance, dyslipidemia, hypertension, chronic inflammation, and impaired glucose metabolism, which collectively increase the risk of type 2 diabetes and cardiovascular diseases. Although current therapeutic strategies, including lifestyle interventions and pharmacological treatments, can be effective in managing specific MetS components, the multifactorial nature of this condition continues to encourage the search for complementary approaches and novel bioactive compounds. Salt-tolerant plants (STPs), particularly halophytes, survive under adverse saline and oxidative stress conditions through specialized physiological and biochemical adaptations, including the production of diverse secondary metabolites such as phenolic acids, flavonoids, sterols, terpenoids and polysaccharides. Several of these compounds have been associated with health-promoting properties, including antioxidant, anti-inflammatory, antidiabetic, antihypertensive, lipid-modulating and cardioprotective effects. This review provides an integrated and critical overview of the ethnomedicinal uses, phytochemistry and bioactivities of STPs with potential relevance to MetS and its associated conditions, namely chronic inflammation, diabetes, hypertension, cardiovascular disorders, dyslipidemia and obesity. The review first introduces the main features of MetS and the relevance of STPs as bioresources, followed by a synthesis of ethnomedicinal uses related to MetS-associated disorders. It then discusses in vitro and in vivo evidence for selected species, extracts and compounds, including reported bioactive metabolites and proposed mechanisms of action when available. Finally, the most promising species, extracts and metabolites are highlighted, together with current limitations and future research needs regarding efficacy, safety, bioavailability, standardization and clinical relevance. Full article
(This article belongs to the Special Issue Bioprospecting of Marine Halophyte Plants)
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