Magnetic Nanoparticles and Nanocomposites for Biomedical Applications

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Nanospecies".

Deadline for manuscript submissions: 25 July 2026 | Viewed by 984

Special Issue Editors


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Guest Editor
Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China
Interests: magnetic induction hyperthermia; hydrogel for bio-application; Chinese massage therapy; cell mechanics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China
2. School of Mechanical and Electrical Engineering, Xinyu University, Xinyu 338004, China
Interests: magnetic nanoparticles for magnetic hyperthermia and magnetic resonance imaging; hydrogels for tissue engineering

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles (MNPs) have established themselves as an important research focus in advanced biomedical applications due to their exclusive chemical and physical properties. Their unique physicochemical properties, such as size-dependent superparamagnetism enabling non-invasive manipulation, precisely controllable surface chemistry permitting targeted functionalization, and inherent capacity for multimodal integration, underpin their paradigm-shifting applications in precision medicine, particularly in magnetic resonance imaging diagnosis, magnetic-guided drug delivery, tumor magnetic hyperthermia, and photothermal therapy.

This Special Issue will highlight cutting-edge scientific advances and innovative theories in the development and application of multifunctional MNPs. It will cover fundamental principles, material innovations, synthesis and surface functionalization strategies, material performance optimization techniques, integrated diagnosis and treatment strategies, and the integration of magnetic hyperthermia with other therapeutic strategies. We aim to explore the unique characteristics of new magnetic materials and their applications in biomedical fields.

We are particularly interested in and invite colleagues to submit original research articles that will fit, but are not limited to, one of the topics listed below:

  • Research and development of novel magnetic nanomaterials for hyperthermia, drug delivery, magnetic resonance imaging diagnosis, and photothermal therapy;
  • Principle and mechanism of magnetothermal conversion, photothermal conversion, targeted drug delivery, and magnetic resonance imaging diagnosis;
  • Numerical simulation and calculation, including the calculation of magnetic properties, micromagnetic simulation, simulation and optimization of temperature fields in hyperthermia, modeling and simulation of drug delivery systems, etc.;
  • Multi-technology integration strategies, such as the combination of cancer diagnosis and treatment, combination therapies of magnetic hyperthermia with other cancer treatments, and the combination of hyperthermia and controlled drug release;
  • Challenges in the promotion of clinical applications, such as material safety and biocompatibility, the optimization and innovation of magnetic field technology, and regulatory and safety considerations in clinical applications.

Short communications, reviews, and original research articles are encouraged. We look forward to your valuable contributions to this Special Issue.

Prof. Dr. Wei Zhang
Dr. Xiaogang Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanomaterial
  • nanocomposites
  • magnetic properties
  • hyperthermia
  • cancer therapy
  • magneto-thermal conversion
  • principles and mechanisms
  • simulation and optimization
  • magnetic resonance imaging
  • drug delivery

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Published Papers (1 paper)

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Research

25 pages, 8395 KB  
Article
Construction of a Novel Nanoparticulate Drug Co-Delivery System for Two Active Components of Traditional Chinese Medicine and Its In Vitro and In Vivo Quality Evaluation
by Siyu Wei, Gang Gui, Cancan Yuan, Ziqi Fan and Qin Xu
Magnetochemistry 2026, 12(3), 38; https://doi.org/10.3390/magnetochemistry12030038 - 19 Mar 2026
Viewed by 647
Abstract
Background: Co-delivery of two drugs with diverse physicochemical properties and a specific administration sequence holds great importance in cancer theranostics to overcome drug resistance and reduce side effects. Paclitaxel (PTX) and hydroxycamptothecin (HCPT) have long been used clinically as chemotherapeutic agents for Nasopharyn-geal [...] Read more.
Background: Co-delivery of two drugs with diverse physicochemical properties and a specific administration sequence holds great importance in cancer theranostics to overcome drug resistance and reduce side effects. Paclitaxel (PTX) and hydroxycamptothecin (HCPT) have long been used clinically as chemotherapeutic agents for Nasopharyn-geal carcinoma (NPC). However, their clinical application is severely restricted by low water solubility, poor stability, and systemic adverse reactions. Nanoparticle-based drug delivery systems provide a promising platform for combination cancer therapy. Methods: In this study, folic acid-modified and dual drug-loaded self-assembled HCPT/PTX@FA@p-PS-SPIONs were successfully fabricated via the emulsification–solvent evaporation method using amphiphilic phosphorylated polystyrene (p-PS). The characterization, cellular uptake, and in vivo pharmacokinetic profiles of the nanoparticles in NPC models were systematically investigated. Result: HCPT/PTX@FA@p-PS-SPIONs were successfully prepared with p-PS as the copolymer backbone. The nanoparticles exhibited a uniform particle size of 196.9 ± 5.5 nm and a zeta potential of −7.3 ± 0.7 mV. The encapsulation efficiency (EE) was 81.4 ± 2.5% for PTX and 67.6 ± 4.1% for HCPT. The drug loading (DL) efficiency was 18.4 ± 1.5% for PTX and 12.2 ± 1.0% for HCPT. HCPT/PTX@FA@p-PS-SPIONs showed favorable biocompatibility. Sustained and sequential release of the two drugs contributed to an enhanced therapeutic effect. Moreover, under magnetic field (MF) guidance, HCPT/PTX@FA@p-PS-SPIONs exhibited stronger inhibitory effects on NPC cells than single-drug, cocktail, or dual-drug groups, demonstrating the superiority of the combined therapy. Pharmacokinetic studies in rats revealed that the half-lives of PTX and HCPT were 3.9 ± 1.2 h and 4.7 ± 1.1 h, respectively, confirming that HCPT/PTX@FA@p-PS-SPIONs could resist rapid metabolism and clearance in vivo. Conclusions: The long-circulating, folic acid-targeted nanoparticles HCPT/PTX@FA@p-PS-SPIONs show great potential for the targeted therapy of nasopharyngeal carcinoma. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles and Nanocomposites for Biomedical Applications)
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