Chronic Lymphocytic Leukemia (CLL): From Benchside to Bedside

A special issue of Lymphatics (ISSN 2813-3307).

Deadline for manuscript submissions: 30 December 2025 | Viewed by 840

Special Issue Editor


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Guest Editor
MD Anderson Cancer Centerdisabled, University of Texas, Houston, TX, USA
Interests: lymphoma; chronic lymphocytic leukemia; translational research; transcription inhibitors; therapeutics for leukemias

Special Issue Information

Dear Colleagues,

This Special Issue of the Lymphatics journal aims to enable the rapid publication of contributions and discoveries concerning all aspects of chronic lymphocytic leukemia (CLL) research, ranging from basic research to clinical applications, with the focus on the translational research.

In the past few decades, with the new understanding of pathogenesis and molecular biology of CLL, the prognosis tools and targeted therapies have been greatly developed. However, it is still far from sufficient to reach robust conclusions and guidelines for treatment. We are pleased to invite you to share with us your perspectives and research results of CLL in the Collection. Topics include, but are not limited to, the following:

- Normal B-cells and CLL B-cells

- Genetics and genomics of CLL

- Microenvironment

- Molecular biology, pathology and diagnostics

- Therapeutics, chemotherapy and chemoimmunotherapy

- Therapeutics, novel targeted therapies including cellular therapies

- Resistance mechanisms

- Curing CLL

Prof. Dr. Varsha Gandhi
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Lymphatics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • B-cells
  • BTK
  • Bcl-2
  • chemoimmunotherapy
  • CLL
  • cure
  • microenvironment
  • resistance

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Published Papers (1 paper)

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Research

17 pages, 871 KB  
Article
The Role of Daily Activity in Risk and Survival Outcomes for Chronic Lymphocytic Leukemia Patients: Baseline Insights from the ADRENALINE Pilot Study
by Pedro Cunha, Ricardo Ribeiro, Andreia Pizarro, Jorge Mota and José Carlos Ribeiro
Lymphatics 2025, 3(4), 45; https://doi.org/10.3390/lymphatics3040045 - 9 Dec 2025
Viewed by 76
Abstract
The ADRENALINE pilot study explores the role of physical activity in health outcomes among patients with Chronic Lymphocytic Leukemia (CLL), focusing on disease markers, functional capacity, immune parameters, and quality of life. This baseline analysis includes treatment-naïve participants enrolled between September 2023 and [...] Read more.
The ADRENALINE pilot study explores the role of physical activity in health outcomes among patients with Chronic Lymphocytic Leukemia (CLL), focusing on disease markers, functional capacity, immune parameters, and quality of life. This baseline analysis includes treatment-naïve participants enrolled between September 2023 and August 2024, prior to randomization. Eleven patients (aged 47–78 years) underwent assessments of body composition, cardiovascular fitness, muscular strength, and immune profiling. Quality of life was evaluated using validated questionnaires (FACIT-F, EORTC QLQ-30/CLL17), and daily activity was objectively measured via accelerometry. Correlation analyses examined associations between physical activity, muscle strength, lean mass, and physical aptitude. Despite high self-reported physical function, participants demonstrated suboptimal body composition and cardiovascular fitness. Accelerometry revealed marked sedentary behavior, particularly among females, and overall activity levels were below current recommendations. Moderate-to-vigorous physical activity correlated positively with muscular strength and lean mass. Immune profiling identified a variability in key markers, warranting further investigation of their relationship with physical activity. These findings highlight the need for tailored interventions to increase activity and reduce sedentary time in CLL patients and support incorporating functional and immune monitoring into survivorship care. Full article
(This article belongs to the Special Issue Chronic Lymphocytic Leukemia (CLL): From Benchside to Bedside)
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