New Insights in Osteoclasts’ Biology
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 5783
Special Issue Editors
Interests: osteoclast; bone resorption; autophagy; epigenetics; bone diseases; rheumatoid arthritis
Special Issues, Collections and Topics in MDPI journals
Interests: lymphocytes; epigenetics; osteo-immunology; primary immunodeficiency; IgG4-related disease; arthritis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the explosion of knowledge triggered by the cloning of RANKL and its partners RANK and OPG in the late 1990s, the comprehension of osteoclasts’ physiology and its involvement in bone diseases characterized by hypersorption have grown steadily. The discovery of new signaling and trafficking pathways have challenged our understanding of bone homeostasis, and has opened the path for the emergence of new therapeutics. Moreover, knowledge about cell interactions has also been refined, particularly with immune T- or B-cells, leading to the definition of the osteoimmunology field. Translational research in bone diseases also benefits from the development of high-throughput screening techniques to refine our understanding of the genetic and epigenetic components involved in bone dysregulation.
The journals IJMS and Life will jointly be publishing a Special Issue covering the topic "New Insights in Osteoclasts’ Biology". This Special Issue on osteoclasts is therefore open to research articles and reviews, and aims to better understand the osteoclastic cell, from its activation to the signaling and regulatory pathways, as well as osteoclast dysfunctions in bone diseases.
You may choose our Joint Special Issue in International Journal of Molecular Sciences.
Prof. Dr. Sophie Roux
Prof. Dr. Hugues Allard-Chamard
Guest Editors
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Keywords
- human osteoclast
- mouse models
- cell differentiation
- multinucleation
- trafficking
- epigenetics
- RANKL pathway
- osteoprotegerin
- cytokines
- micro-RNAs
- bone diseases
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