Special Issue "New Insights in Osteoclasts’ Biology"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 3109

Special Issue Editors

Prof. Dr. Sophie Roux
E-Mail Website
Guest Editor
Université de Sherbrooke, Sherbrooke, QC, Canada
Interests: osteoclast; bone resorption; autophagy; epigenetics; bone diseases; rheumatoid arthritis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hugues Allard-Chamard
E-Mail Website
Guest Editor
Université de Sherbrooke, Sherbrooke, QC, Canada
Interests: lymphocytes; epigenetics; osteo-immunology; primary immunodeficiency; IgG4-related disease; arthritis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the explosion of knowledge triggered by the cloning of RANKL and its partners RANK and OPG in the late 1990s, the comprehension of osteoclasts’ physiology and its involvement in bone diseases characterized by hypersorption have grown steadily. The discovery of new signaling and trafficking pathways have challenged our understanding of bone homeostasis, and has opened the path for the emergence of new therapeutics. Moreover, knowledge about cell interactions has also been refined, particularly with immune T- or B-cells, leading to the definition of the osteoimmunology field. Translational research in bone diseases also benefits from the development of high-throughput screening techniques to refine our understanding of the genetic and epigenetic components involved in bone dysregulation.

The journals IJMS and Life will jointly be publishing a Special Issue covering the topic "New Insights in Osteoclasts’ Biology". This Special Issue on osteoclasts is therefore open to research articles and reviews, and aims to better understand the osteoclastic cell, from its activation to the signaling and regulatory pathways, as well as osteoclast dysfunctions in bone diseases.

You may choose our Joint Special Issue in International Journal of Molecular Sciences.

Prof. Dr. Sophie Roux
Prof. Dr. Hugues Allard-Chamard
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human osteoclast
  • mouse models
  • cell differentiation
  • multinucleation
  • trafficking
  • epigenetics
  • RANKL pathway
  • osteoprotegerin
  • cytokines
  • micro-RNAs
  • bone diseases

Published Papers (1 paper)

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Review

Review
Osteoclasts and Microgravity
Life 2020, 10(9), 207; https://doi.org/10.3390/life10090207 - 16 Sep 2020
Cited by 15 | Viewed by 2900
Abstract
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related impairment of [...] Read more.
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related impairment of osteocyte and osteoblast function and the consequent upregulation of osteoclast-mediated bone resorption. This review describes the ontogeny of osteoclast hematopoietic stem cells and the contributions macrophage colony stimulating factor, receptor activator of the nuclear factor-kappa B ligand, and the calcineurin pathways make in osteoclast differentiation and provides details of bone formation, the osteoclast cytoskeleton, the immune regulation of osteoclasts, and osteoclast mechanotransduction on Earth, in space, and under conditions of simulated microgravity. The article discusses the need to better understand how osteoclasts are able to function in zero gravity and reviews current and prospective therapies that may be used to treat osteoclast-mediated bone disease. Full article
(This article belongs to the Special Issue New Insights in Osteoclasts’ Biology)
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