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Life
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Medicinal Plants in the Strategies for Prevention and Treatment of...
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Medicinal Plants in the Strategies for Prevention and Treatment of Multidrug Resistance Microbe and Chronic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Plant Science".

Deadline for manuscript submissions: closed (1 January 2023) | Viewed by 4153

Special Issue Editors

Prof. Dr. Samy Selim

E-Mail Website
Guest Editor
Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Sakaka 72341, Saudi Arabia
Interests: plant biology, natural biological activities products from medicinal plants and microorganisms, antimicrobial resistance microorganisms; molecular biology; biotechnology
Dr. Amr Elkelish

E-Mail Website
Guest Editor
Faculty of Science, Suez Canal University, Ismailia, Egypt
Interests: transcriptomic and proteomic techniques; bioinformatics; molecular biology; biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medicinal plants remain a predominant health treatment in many cultures, with more than 80% of the population in developing countries wholly depending on medicinal plants for medical purposes. Many diseases can be effectively cured by different plant parts (leaf, bark, and root). Moreover, medicinal plants can be used to prevent and/or revert abnormalities. Recently, plants have been extensively used in the form of drugs and dietary supplements. Many researchers in pharmacology, microbiology, botany, and phytochemistry have directed their efforts towards discovering novel bioactive compounds with potential to treat various diseases.

Prof. Dr. Samy Selim
Dr. Amr Elkelish
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal plants, chemical composition, bioactive compounds
  • multidrug resistance microbe
  • nanotechnology
  • drug discovery
  • biological activities, plant stress

Published Papers (2 papers)

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Research

10 pages, 4930 KiB  
Communication
Microwave-Assisted Hydrodistillation of Essential Oil from Plectranthus amboinicus: Evaluation of Its Antifungal Effect and Chemical Composition
by Oscar Antonio-Gutiérrez, José Antonio Alvízar-Martínez, Rodolfo Solano, Alfonso Vásquez-López, Sandra Luz Hernández-Valladolid, Hermes Lustre-Sánchez, Hilda Elizabet Flores-Moctezuma, Erick de Jesús de Luna-Santillana and Luicita Lagunez-Rivera
Life 2023, 13(2), 528; https://doi.org/10.3390/life13020528 - 15 Feb 2023
Cited by 2 | Viewed by 1586
Abstract
Fusarium wilt, a vascular syndrome in a wide range of plants, is caused by the pathogen Fusarium Oxysporum. The objective of this investigation was to evaluate the antifungal effect of four essential oils (EOs) (Plectranthus amboinicus, Syzygium aromaticum, Lippia [...] Read more.
Fusarium wilt, a vascular syndrome in a wide range of plants, is caused by the pathogen Fusarium Oxysporum. The objective of this investigation was to evaluate the antifungal effect of four essential oils (EOs) (Plectranthus amboinicus, Syzygium aromaticum, Lippia alba, and Rosmarinus officinalis), which were obtained by using microwave-assisted hydrodistillation (MAH), against F. oxysporum. The yield obtained from P. amboinicus with the use of MAH was 0.2%, which was higher than that of a conventional extraction; its extraction time was also shorter. For concentrations of 100 and 300 μL/L, P. amboinicus caused an inhibition rate of 27.2 and 55.7%, respectively, while S. aromaticum caused an inhibition rate of 23.1 and 87.3%, respectively. It was observed that increasing the concentration also increased the % inhibition rate. The extracts of L. alba and R. officinalis caused an inhibition rate of 14.5 and 14.7% at 500 µL/L, respectively, at 10 days of incubation, while at this concentration, P. amboinicus and S. aromaticum achieved 100%. The major chemical compounds of P. amboinicus were carvacrol (41.20%), o-cymene (11.61%), caryophyllene (11.45%), α-bergamotene (7.71%), and caryophyllene oxide (4.62%), and these monoterpene hydrocarbons were responsible for the biological activity. The essential oil of P. amboinicus in appropriate concentrations is a potent antifungal agent that could be used for the control of F. oxysporum. Full article
(This article belongs to the Special Issue Medicinal Plants in the Strategies for Prevention and Treatment of Multidrug Resistance Microbe and Chronic Diseases)
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13 pages, 4652 KiB  
Article
Mechanism of Wuyao–Ginseng Medicine Pair in the Prevention and Treatment of Diarrhea-Type Irritable Bowel Syndrome Based on Gene Expression Omnibus Chip Data
by Wenjing Sun, Ruizi Qing, Zhiqiang Fan, Qin He, Jinhong Wu, Yang He, Linqi Ouyang, Zhen Chen and Guiming Deng
Life 2023, 13(2), 339; https://doi.org/10.3390/life13020339 - 27 Jan 2023
Cited by 1 | Viewed by 1887
Abstract
Based on a Gene Expression Omnibus (GEO) chip analysis combined with network pharmacology and molecular docking technology, in this study we explored the molecular targets and mechanism of the wuyao–ginseng medicine pair in the prevention and treatment of diarrhea-type irritable bowel syndrome (IBS-D). [...] Read more.
Based on a Gene Expression Omnibus (GEO) chip analysis combined with network pharmacology and molecular docking technology, in this study we explored the molecular targets and mechanism of the wuyao–ginseng medicine pair in the prevention and treatment of diarrhea-type irritable bowel syndrome (IBS-D). The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to search for the chemical constituents and targets of wuyao and ginseng. The UniProt database was used to search for the target gene name. In the GEO database, IBS was searched to obtain GSE36701 and GSE14841 microarray data. We imported the intersection targets into the STRING database to construct a protein–protein interaction (PPI) network. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (Go) pathway analyses were performed using the Metascape database. A total of 30 active ingredients of wuyao–ginseng, 171 drug targets, 1257 IBS differentially expressed genes, and 20 drug-disease intersection genes were obtained from the GEO data. We screened the results and obtained the core active ingredients beta-sitosterol, DMPEC, Boldine, etc.; the core targets NCOA2, EGFR, VEGFA, etc.; and the key pathways P13K-Akt, MAPK, etc. The wuyao–ginseng medicine pair may be involved in inflammation-related signaling pathways, acting on disease targets such as NCOA2, EGFR, and VEGFA as well as pathways such as P13K-Akt and MAPK, thereby playing a key role in the prevention and treatment of IBS-D. Full article
(This article belongs to the Special Issue Medicinal Plants in the Strategies for Prevention and Treatment of Multidrug Resistance Microbe and Chronic Diseases)
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