Special Issue "Molecular Mechanisms of Gestational Length Regulation"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 15 January 2021.

Special Issue Editor

Dr. Jennifer Condon
Guest Editor
Wayen State University Detroit, Michigan, USA
Interests: gestational length; uterine myocyte endoplasmic reticulum stress; uterotonic; pregnancy

Special Issue Information

Dear Colleagues,

Previous preterm birth and cervical length measurement are currently the strongest predictors for a subsequent preterm birth, however nulliparous women with no past obstetrical history continue to remain at a heightened risk. Thus the ability to accurately predict and prevent preterm labor remains one of the most critical challenges facing modern obstetrics. Currently it is clear that progesterone and progesterone receptor action are critical in the maintenance of uterine quiescence. Mechanisms that involve changes in ionic conductance that extend relaxation effects on the uterus have also been found to maintain uterine quiescence during pregnancy. Although largely idiopathic, multiple risk factors have been attributed to cause preterm labor. However to date it remains unclear as to the events that precede and elicit the signals that allow for the onset of preterm uterine contractions and premature labor. As a consequence, although the rates of preterm birth continue to decrease in the US there has been a steady rise in the prevalence of preterm birth globally over the past decade and thereby continues to pose an acute risk for neurodevelopmental and respiratory complications that adversely effect neonatal health. In this issue we will cover trending research advances in the areas of endocrine function, ion channel regulation, exosome and novel paracrine signaling, immunological and inflammatory mediators, mechanical properties of the soft tissues involved in pregnancy and preterm birth and labor as a target of genomic research.

Dr. Jennifer Condon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Hormones
  • Ion Channels
  • Cervix
  • Fetal membranes
  • Exosome
  • Secretome
  • Inflammasome
  • Prematurity
  • Immune response
  • Uterus
  • Contraction
  • Genomics

Published Papers

This special issue is now open for submission.
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