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Life
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Biologically-Relevant Materials
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Biologically-Relevant Materials

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".

Deadline for manuscript submissions: closed (17 November 2021) | Viewed by 5471

Special Issue Editors

Dr. Kari Stone

E-Mail Website
Guest Editor
Department of Chemistry, Lewis University, Romeoville, IL 60446, USA
Interests: biocatalysis; metalloenzymes; bioinorganic; green chemistry; chemical education
Special Issues, Collections and Topics in MDPI journals
Dr. Daniel Kissel

E-Mail Website
Guest Editor
Department of Chemistry, Lewis University, Romeoville, IL 60446, USA
Interests: MOFs; coordination chemistry; materials science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The bioinspired development of materials for a myriad of applications has converged researchers from diverse disciplinary backgrounds in the life sciences, chemistry, physics and engineering fields. Fundamental understanding of how biological materials or bioinspired materials interface with biological structure and function is essential for the design of biocompatible materials, biocatalysis, and biomimetic materials. The development of biologically relevant materials is imperative to give rise to the next generation of bioinspired engineering. In this Special Issue we invite original research articles, reviews, and case reports in any context that intersects the fields of biological and materials chemistry for the creation of biologically-relevant materials.

Deadlines:

  • Early-bird deadline: 31 December 2020, with 20% discount on APCs.
  • Last deadline: 28 May 2021.

Dr. Kari Stone
Dr. Daniel Kissel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioinspired materials
  • Biological materials
  • Biomimetic materials
  • Biomedical engineering
  • Sensors
  • Biosensors
  • Biopolymers
  • Nanomedicine
  • Biomedicine
  • Biotechnology
  • Biophysics

Published Papers (2 papers)

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Research

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10 pages, 2730 KiB  
Article
Injectable Hydrogel for Cu2+ Controlled Release and Potent Tumor Therapy
by Chunyu Huang, Bei Chen, Mingzhu Chen, Wei Jiang and Wei Liu
Life 2021, 11(5), 391; https://doi.org/10.3390/life11050391 - 26 Apr 2021
Cited by 9 | Viewed by 1945
Abstract
Disulfiram (DSF) is an important drug for the treatment and management of alcohol dependency. This drug has been approved by US-FDA, and its activity against the tumor is dependent on copper ion (Cu2+). However, the copper toxicity (caused via external copper) [...] Read more.
Disulfiram (DSF) is an important drug for the treatment and management of alcohol dependency. This drug has been approved by US-FDA, and its activity against the tumor is dependent on copper ion (Cu2+). However, the copper toxicity (caused via external copper) and its intrinsic anfractuous distribution in the human body have adversely suppressed the mechanism of DSF in in vivo. In this study, we aimed to design an injectable hydrogel, as CRC (Cu2+ release controller) for the effective treatment of tumors. The hydrogels of agarose have been used for wrapping of CuCl2, and hierarchical microparticles (HMP) for the generation of CRC system. When the laser irradiations (808 nm) have been provided to the system, light energy is transferred into heat energy, which results in the hydrogel hydrolysis (reversible) due to the overheating effect. This is followed by a reaction with DSF (pre-injected) to suppress tumor progression. Hence, the CRC system brings innovative ideas for designing of a Cu2+ delivery system. Full article
(This article belongs to the Special Issue Biologically-Relevant Materials)
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Review

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24 pages, 1270 KiB  
Review
Current Status of Brain Tumor in the Kingdom of Saudi Arabia and Application of Nanobiotechnology for Its Treatment: A Comprehensive Review
by Afrasim Moin, Syed Mohd Danish Rizvi, Talib Hussain, D. V. Gowda, Gehad M. Subaiea, Mustafa M. A. Elsayed, Mukhtar Ansari, Abulrahman Sattam Alanazi and Hemant Yadav
Life 2021, 11(5), 421; https://doi.org/10.3390/life11050421 - 5 May 2021
Cited by 7 | Viewed by 2992
Abstract
Objective: Brain tumors are the most challenging of all tumors and accounts for about 3% of all cancer allied deaths. The aim of the present review is to examine the brain tumor prevalence and treatment modalities available in the Kingdom of Saudi Arabia. [...] Read more.
Objective: Brain tumors are the most challenging of all tumors and accounts for about 3% of all cancer allied deaths. The aim of the present review is to examine the brain tumor prevalence and treatment modalities available in the Kingdom of Saudi Arabia. It also provides a comprehensive analysis of the application of various nanotechnology-based products for brain cancer treatments along with their prospective future advancements. Methods: A literature review was performed to identify and summarize the current status of brain cancer in Saudi Arabia and the scope of nanobiotechnology in its treatment. Results: Depending upon the study population data analysis, gliomas, astrocytoma, meningioma, and metastatic cancer have a higher incidence rate in Saudi Arabia than in other countries, and are mostly treated in accordance with conventional treatment modalities for brain cancer. Due to the poor prognosis of cancer, it has an average survival rate of 2 years. Conventional therapy includes surgery, radiotherapy, chemotherapy, and a combination thereof, but these do not control the disease’s recurrence. Among the various nanomaterials discussed, liposomes and polymeric nanoformulations have demonstrated encouraging outcomes for facilitated brain cancer treatment. Conclusions: Nanomaterials possess the capacity to overcome the shortcomings of conventional therapies. Polymer-based nanomaterials have shown encouraging outcomes against brain cancer when amalgamated with other nano-based therapies. Nonetheless, nanomaterials could be devised that possess minimal toxicity towards normal cells or that specifically target tumor cells. In addition, rigorous clinical investigations are warranted to prepare them as an efficient and safe modality for brain cancer therapy. Full article
(This article belongs to the Special Issue Biologically-Relevant Materials)
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