The Genetics of Animal Metabolic Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Animal Science".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 4835

Special Issue Editors


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Guest Editor
Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, China
Interests: animal model; gene editing; cardiology; metabolic disease
Department of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou, China
Interests: porcine disease model; gene editing; ADPKD; kidney disease

Special Issue Information

Dear Colleagues,

Metabolic diseases, such as obesity, diabetes, atherosclerosis and gout etc., are major life-threatening disorders for human-beings, afflicting millions of people worldwide annually. To seek better therapeutic approaches, lots of efforts have been made to understand the genetic basis of these diseases. To advance our understanding of metabolic diseases, the present special issue, edited by Dr. Lenan Zhuang, will focus on the genetics of metabolic diseases using animal models, including rodents, non-human primates, sheep, and pigs. Topics will encompass molecular/cellular mechanisms of metabolic disorders, novel perspective on the etiology, causative variants identification and validation, new applicable animal models. All types of papers, e.g., original research papers, short communications, or reviews are welcome to submit.

Dr. Lenan Zhuang
Dr. Jin He
Guest Editors

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Keywords

  • genetics
  • metabolic diseases
  • animal models

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Published Papers (1 paper)

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Research

19 pages, 3113 KiB  
Article
Naringin Attenuates the Diabetic Neuropathy in STZ-Induced Type 2 Diabetic Wistar Rats
by Md Fahim Ahmad, Nida Naseem, Inamur Rahman, Nazia Imam, Hina Younus, Swaroop Kumar Pandey and Waseem A. Siddiqui
Life 2022, 12(12), 2111; https://doi.org/10.3390/life12122111 - 15 Dec 2022
Cited by 23 | Viewed by 4234
Abstract
The application of traditional medicines for the treatment of diseases, including diabetic neuropathy (DN), has received great attention. The aim of this study was to investigate the ameliorative potential of naringin, a flavanone, to treat streptozotocin-induced DN in rat models. After the successful [...] Read more.
The application of traditional medicines for the treatment of diseases, including diabetic neuropathy (DN), has received great attention. The aim of this study was to investigate the ameliorative potential of naringin, a flavanone, to treat streptozotocin-induced DN in rat models. After the successful induction of diabetes, DN complications were measured by various behavioral tests after 4 weeks of post-induction of diabetes with or without treatment with naringin. Serum biochemical assays such as fasting blood glucose, HbA1c%, insulin, lipid profile, and oxidative stress parameters were determined. Proinflammatory cytokines such as TNF-α and IL-6, and neuron-specific markers such as BDNF and NGF, were also assessed. In addition, pancreatic and brain tissues were subjected to histopathology to analyze structural alterations. The diabetic rats exhibited increased paw withdrawal frequencies for the acetone drop test and decreased frequencies for the plantar test, hot plate test, and tail flick test. The diabetic rats also showed an altered level of proinflammatory cytokines and oxidative stress parameters, as well as altered levels of proinflammatory cytokines and oxidative stress parameters. Naringin treatment significantly improved these parameters and helped in restoring the normal architecture of the brain and pancreatic tissues. The findings show that naringin’s neuroprotective properties may be linked to its ability to suppress the overactivation of inflammatory molecules and mediators of oxidative stress. Full article
(This article belongs to the Special Issue The Genetics of Animal Metabolic Disease)
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