Special Issue "Alzheimer's Amyloid: Structure, Function, and Disease"
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".
Deadline for manuscript submissions: closed (30 August 2023) | Viewed by 2043
Interests: structural biology; computational biology; protein crystallography; molecular modeling; molecular docking; drug design; molecular dynamics
Special Issues, Collections and Topics in MDPI journals
Alzheimer’s disease (AD), a fatal neurodegenerative disease, has puzzled the scientific community for over a century. AD currently affects 50 million patients and is estimated to reach 152 million in 2050. The COVID-19 pandemic may have significantly increased these estimates according to an alarming report showing a hazard ratio of 1.69 for new-onset AD in older people as a late sequel of COVID-19. This may substantially increase the already enormous burden on public health budgets, health care and older people and societies. Therefore, despite the controversial approval of an expensive therapy with aducanumab and expected approval of the use of monoclonal antibodies against β-amyloid, there is an urgent need to find cheap and effective small-molecule treatments for this disease. For this Special Issue, we welcome studies concerning inhibitors of β-amyloid aggregation into oligomers and mature fibrils as well as compounds dissolving mature fibrils. Computational studies docking new compounds to β-amyloid monomers, oligomers and fibrils and molecular dynamics experiments alone or preliminary to “wet” biochemistry leading to elucidation of the mechanism underlying the inhibition of aggregation or dissolution of fibrils are also encouraged.
Dr. Adam Jarmuła
Dr. Dariusz Stępkowski
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Alzheimer’s disease
- in silico studies
- inhibition of fibrillation
- dissolution of amyloid fibrils