Synthesis and Evaluation of Novel Compounds with Anticancer Activity
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2621
Special Issue Editors
Interests: chemotherapy; anti-cancer drugs; vitamin B6 (pyridoxine); derivatives of curcumin and dehydrozingerone; preclinical drug study
2. JSC "Tatchempharmpreparaty", Kazan, Russia
Interests: preclinical and clinical drug study; anticancer drugs; analogs of estradiol; ABC transporters; multidrug resistance
Special Issue Information
Dear Colleagues,
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Drug treatment, together with surgical operation, radiotherapy and biotherapy, constitute the main approaches to cancer treatment. Small molecules—products of chemical synthesis—are still the basis of classical anticancer drugs, such as alkylating agents, antimetabolites, antibiotics, vinca alkaloids, taxanes and topoisomerase inhibitors. Classical anticancer drugs target general biological processes such as DNA synthesis and mitosis and, therefore, are characterized by low selectivity and high cytotoxicity towards rapidly dividing normal cells. Despite this, small molecules still make up 75% of the anticancer drug market, and are cheaper to manufacture, and easier to pack into tablets and capsules for oral use than biological macromolecules. Additionally, small molecules can provide targeted tumor therapy, in particular tyrosine kinase inhibitors, such as imatinib, which block the proliferation of tumor cells that overexpress tyrosine kinases. In this regard, the synthesis and evaluation of small antitumor molecules remains an urgent task for researchers to this day. A newer direction is the synthesis of therapeutic peptides, polypeptides and nucleic acids, which are also of great interest for the development of anticancer drugs. Contributors are encouraged to submit manuscripts and reviews covering but not limited to the following topics:
- Synthesis of novel analogs of known anticancer agents and evaluation of their biological activity;
- Synthesis and evaluation of natural alkaloid derivatives (such as curcumin, dehydrozingerone, colchicine, vinca alkaloids and others) with anticancer activity;
- Synthesis and evaluation of short peptides and polypeptides that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour blood vessels;
- Development and evaluation of siRNAs, shRNAs and other types of nucleic acids as an effective approach to silence cancer-causing genes.
Dr. Oksana Viktorovna Bondar
Dr. Alfiya Iksanova
Guest Editors
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Keywords
- anticancer agents
- synthesis
- design
- biological activity
- natural products
- anticancer peptides
- anticancer nucleic acids
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