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Life
Special Issues
Advanced Therapeutic and Diagnostic Strategies in Urological Infections
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Advanced Therapeutic and Diagnostic Strategies in Urological Infections

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2231

Special Issue Editors

Dr. Rǎzvan Cosmin Petca

E-Mail Website
Guest Editor
Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: urinary tract infections; UTI; antimicrobial resistance; AMR; uropathogens; renal lithiasis; renal cancer; prostate cancer; urinary bladder cancer
Prof. Dr. Viorel Jinga

E-Mail Website
Guest Editor
Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Interests: prostate cancer; UTI; AMR; uropathogens; genomic sequencing; prostate cancer; renal cancer; renal lithiasis.

Special Issue Information

Dear Colleagues,

We are organizing a Special Issue entitled "Advanced Therapeutic and Diagnostic Strategies in Urological Infections" to be published in the journal Life.

Urological infections are a diverse group of conditions that significantly impact public health; they include not only urinary tract infections (UTIs), which alone affect more than 150 million individuals annually, but also other important conditions like cystitis, prostatitis, and epididymitis.

Many infections in urology are caused by microbiologically challenging pathogens, making them difficult to manage clinically. This complexity encompasses a range of disorders, from UTIs to prostatitis and epididymitis. Therefore, multidisciplinary approaches that cover advanced therapeutic and diagnostic strategies become critically important. These approaches aim to improve treatment outcomes, ensure the cost-effectiveness of interventions, and mitigate potential risks, such as the emergence of antibiotic resistance, toxicity, and the selection of hard-to-treat pathogenic strains. Given the evolving nature of urinary system infections, innovations in treatment and diagnostic modalities are imperative.

Topics of interest include, but are not limited to, the following:

  • Antimicrobial resistance;
  • Recurrent cystitis;
  • Complicated urinary tract infections;
  • Gram-positive and Gram-negative uropathogens;
  • Treatment innovations in various urological infections;
  • Innovations in the prevention and control of urological infections;
  • Catheter-associated complications and management.

This Special Issue invites exciting studies that will expand our current understanding in the field of urology. In addition to research that has steadily improved existing issues, we welcome research papers that present new and significant results.

Please provide a working title and brief abstract in advance so that we can conduct a suitability check. We look forward to receiving your valuable contributions.

Dr. Rǎzvan Cosmin Petca
Prof. Dr. Viorel Jinga
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • urinary tract infections (UTIs)
  • urethritis
  • prostatitis
  • orchitis
  • epididymitis
  • pyelonephritis
  • antimicrobial resistance
  • antibiotic resistance
  • uropathogens
  • E. coli
  • Klebsiella
  • Enterococcus

Published Papers (2 papers)

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Research

11 pages, 234 KiB  
Article
Autovaccine-Based Immunotherapy: A Promising Approach for Male Recurrent Urinary Tract Infections
by Alexandru Ciudin, Bernat Padulles, Razvan Popescu and Pasqualino Manasia
Life 2024, 14(1), 111; https://doi.org/10.3390/life14010111 - 10 Jan 2024
Cited by 1 | Viewed by 862
Abstract
Background: Recurrent Urinary Tract Infections (UTIs) in men range from 0.9 to 2.4/1000 individuals in younger men to 7.7/1000 in those over 85, significantly impacting their quality of life. Preventive strategies include autovaccines, but limited evidence exists for males. Methods: A prospective monocentric, [...] Read more.
Background: Recurrent Urinary Tract Infections (UTIs) in men range from 0.9 to 2.4/1000 individuals in younger men to 7.7/1000 in those over 85, significantly impacting their quality of life. Preventive strategies include autovaccines, but limited evidence exists for males. Methods: A prospective monocentric, open-label observational study was conducted from August 2018 to August 2021, with follow-up until August 2023 including patients with recurrent UTIs treated with immunotherapy. We evaluated the incidence rate of UTIs per year, the incidence rate of episodes after two or three rounds of the autovaccine, and quality of life measured with the IPSS-QoL questionnaire. Results: A total of 49 patients fulfilled inclusion criteria. The mean age was 72 years (±15), and the median 61. The evolution of UTIs number of episodes after the autovaccine rounds: −37.74% for the first round from 5.3 to 3.3; −33.33% for the second round from 3.3 to 2.2; −45.45% for the third round from 2.2 to 1.2. The mean IPSS score improved from 10.69 to 7.27 after the treatment (32%). The mean QoL subscore enhancement was from 4.22 to 1.92 (54%). With a mean follow-up of 3 years, only nine patients required retreatment. Conclusion: Autovaccine treatment significantly reduced the number of UTI episodes, with a cumulative effect observed after multiple rounds of treatment, demonstrating an enhancement in QoL and with sustained effectiveness and a low need for retreatment. Full article
(This article belongs to the Special Issue Advanced Therapeutic and Diagnostic Strategies in Urological Infections)
15 pages, 1341 KiB  
Article
Update on Urinary Tract Infection Antibiotic Resistance—A Retrospective Study in Females in Conjunction with Clinical Data
by Cristian Mareș, Răzvan-Cosmin Petca, Răzvan-Ionuț Popescu, Aida Petca, Răzvan Mulțescu, Cătălin Andrei Bulai, Cosmin Victor Ene, Petrișor Aurelian Geavlete, Bogdan Florin Geavlete and Viorel Jinga
Life 2024, 14(1), 106; https://doi.org/10.3390/life14010106 - 9 Jan 2024
Cited by 1 | Viewed by 1017
Abstract
Urinary tract infections (UTIs) represent a frequent pathology among the female population that has become more and more difficult to treat in the past decade, considering the increase in antibiotic resistance—a serious global public health problem. A cross-sectional retrospective study was conducted for [...] Read more.
Urinary tract infections (UTIs) represent a frequent pathology among the female population that has become more and more difficult to treat in the past decade, considering the increase in antibiotic resistance—a serious global public health problem. A cross-sectional retrospective study was conducted for six months to report an update regarding the rates of resistance and susceptibility of uropathogens necessary for optimal treatment. A total of 5487 patients were screened, of which 524 (9.54%) were female patients who met the criteria for inclusion in the study. Escherichia coli was the most common pathogen, representing 290 cases (55.34%), followed by Enterococcus spp. 82 (15.64%). Escherichia coli presented the highest resistance to amoxicillin-clavulanic acid (R = 33.1%), followed by trimethoprim-sulfamethoxazole (R = 32.41%) and levofloxacin (R = 32.06%). The highest sensitivity rates were observed for fosfomycin (S = 96.55%), followed by imipenem (S = 93.1%). Enterococcus spp. showed the highest resistance to levofloxacin (R = 50.0%), followed by penicillin (R = 39.02%). The highest sensitivity was observed for fosfomycin (S = 90.24%), linezolid (S = 89.02%), and nitrofurantoin (S = 86.58%). The second most frequent Gram-negative uropathogen was represented by Klebsiella spp., which had the highest resistance to amoxicillin-clavulanic acid (R = 35.89%), followed by levofloxacin (R = 25.64) and trimethoprim-suflamethoxazole (R = 24.35%). The most frequently associated pathology was an episode of UTI in the previous year, followed by diabetes and chronic kidney disease. Antibiotic resistance is a serious problem for all clinicians who treat UTIs. An up-to-date knowledge of antibiotic resistance rates is a major necessity to stop its evolution. Overall, the highest resistance rates were observed for aminopenicillins, fluoroquinolones, and trimethoprim-sulfamethoxazole. The best susceptibility rates were observed for fosfomycin, nitrofurantoin, and carbapenems. Our report aims to guide clinicians whenever they are forced to prescribe antibiotics empirically. Full article
(This article belongs to the Special Issue Advanced Therapeutic and Diagnostic Strategies in Urological Infections)
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