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Life
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Stem Cells Therapy
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Stem Cells Therapy

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (15 November 2020) | Viewed by 5040

Special Issue Editor

Prof. Dr. Rasul Chaudhry

E-Mail Website
Guest Editor
Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
Interests: stem cell research; cell therapy; bioinformatics; tissue engineering; regulation of gene expression; biotechnology and toxicology

Special Issue Information

Dear Colleagues,

Recently, advances in stem cell research and regenerative medicine have provided promising opportunities in the emerging field of “Stem Cell Therapy”, which will be the topic of the upcoming Special Issue of Life.  The goal of this Special Issue is to report on state-of-the-art research innovations, findings, and developments in stem-cell-based therapies from experts, researchers, and practitioners.  The Special Issue will be of interest to a wide-ranging audience, including researchers, scientists, clinicians, and professionals from academia, government, and industry, as well as the public at large. This issue will focus on the use of multipotent and pluripotent stem cells and their derivatives to treat a broad range of diseases and dysfunctions, with a special focus on human degenerative diseases, inflammatory diseases, musklosletal dysfunctions, wound repair, and cancers.  We welcome submissions of the latest research and reviews on all aspects ranging from cell and molecular biology to clinical trials.

Prof. Dr. Rasul Chaudhry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative medicine
  • degenerative diseases
  • inflammatory diseases
  • wound repair
  • musculoskeletal disorders
  • cancers

Published Papers (2 papers)

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Research

15 pages, 4936 KiB  
Article
Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells
by Da Hee Jung, Malk Eun Pak, Hong Ju Lee, Sung Min Ahn, Young Ju Yun, Yong-Il Shin, Hwa Kyoung Shin, Seo-Yeon Lee and Byung Tae Choi
Life 2020, 10(10), 240; https://doi.org/10.3390/life10100240 - 14 Oct 2020
Cited by 1 | Viewed by 2275
Abstract
Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA could promote functional [...] Read more.
Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA could promote functional improvements and neurogenesis in a neonatal HI rat model. A neonatal HI rat model was induced by permanent ligation of the left carotid artery in postnatal day 7 pups. EA for neonatal HI rats was performed at 2 Hz (1, 3, or 5 mA; 20 min) from 4–6 weeks after birth. HI rats undergoing EA had improved motor and memory function, with the greatest improvement after 3 mA EA. The corpus callosum was significantly thicker and showed a significant increase in proliferating astrocytes in the 3 mA EA group. We observed proliferating cells and a greater number of newly developed neurons and astrocytes in the subventricular zone and dentate gyrus of the 3 mA EA group than in those of the HI group. These results suggest that EA promotes functional improvements following neonatal HI assault via the proliferation and differentiation of neural stem cells. This effect was the strongest after 3 mA EA, suggesting that this is the optimal treatment dose. Full article
(This article belongs to the Special Issue Stem Cells Therapy)
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17 pages, 5192 KiB  
Article
Effects of Diesel Exhaust Particles on Mouse Gastric Stem Cells
by Heba Al-Sadik, Subi Sugathan, Prashanth Saseedharan, Shahrazad Sulaiman, Sumaya Beegam, Abderrahim Nemmar, Samir Attoub and Sherif M. Karam
Life 2020, 10(8), 149; https://doi.org/10.3390/life10080149 - 12 Aug 2020
Cited by 1 | Viewed by 2387
Abstract
Stem cells have attracted many scientists because of their unique properties and therapeutic applications. However, very little is known on the environmental toxins that could affect their biological features. This study focuses on the consequences of the exposure of a cell line representative [...] Read more.
Stem cells have attracted many scientists because of their unique properties and therapeutic applications. However, very little is known on the environmental toxins that could affect their biological features. This study focuses on the consequences of the exposure of a cell line representative of the mouse gastric stem/progenitor (mGS) cells to diesel exhaust particles (DEPs). These immortal cells were cultured using routine protocols. The DEPs were added to the culture media at 1, 10, and 100 µg/mL for 1 to 72 h. The cells were assayed for their viability, migration, oxidative stress, and the expression of genes specific for cell proliferation, pluripotency, and death. DEPs induced a reduction in the metabolic activity of mGS cells, only at a high concentration of 100 µg/mL. However, no significant effects were detected on cell migration, oxidative stress markers (glutathione and thiobarbituric acid reactive substances), and cell death related proteins/genes. Interestingly, these findings were associated with down-regulation of Notch 2 and 3 and Bmi-1 proteins and activation of STAT3 involved in the regulation of the fate of stem cells. In conclusion, this study demonstrates that mGS cells have some resistance to oxidative stress and apoptosis when exposed to DEPs at the expense of their stemness. Full article
(This article belongs to the Special Issue Stem Cells Therapy)
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