Proteotranscriptomics-Guided Research on Insects and Arachnids Toxins

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Proteins and Proteomics".

Deadline for manuscript submissions: closed (24 March 2023) | Viewed by 2222

Special Issue Editors

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Guest Editor
Institut National Polytechnique Félix Houphouët Boigny de Yamoussoukro, Yamoussoukro, Côte d'Ivoire
Interests: bioinformatics; transcriptomics; venomics; proteomics; next-gen sequencing

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Guest Editor
Laboratory of Genomics and Proteomics of Disease Vectors, Biology Centre, Czech Academy of Sciences, Institute of Parasitology, 37005 Budweis, Czech Republic
Interests: proteomics; next generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; kunitz; tick; insect; vector-host interaction
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Special Issue Information

Dear Colleagues, 

Venoms are rich cocktails of active peptides, proteins, and enzymes that are very commonly used by various species to capture their prey or defend themselves. In most cases, these toxic secretions from one organism are injected into the internals of another organism through a mechanical injury. The exploration of venoms and their selected components—resulting from decades of evolution—have revealed dozens of therapeutically active and promising drug candidates. This exploration has implied various technical approaches, among which proteomics, transcriptomics, and bioinformatics are today in pole position. In this Special Issue, we first want to highlight and demonstrate—once again and again if necessary—how valuable molecules issued from insects and arthropods venoms can be for new drug candidate discovery. Since insects and arthropods account for most species of eukaryotic life on Earth, it seems obvious to expect that the richness of their venom arsenal is far from being completely explored. Second, this Special Issue aims to promote innovative results from research conducted on “noncommon” species focusing on the venom role in species adaptation. We therefore expect authors to share complete and exciting evidence of valuable action of discovered or optimized molecules.

Dr. Dominique Kadio Koua
Dr. Michail Kotsyfakis
Guest Editors

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  • insect toxins
  • arachnid toxins
  • venom gland transcriptomics
  • venom proteomics
  • therapeutic valorization of venom components

Published Papers (1 paper)

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17 pages, 2380 KiB  
Comparative Proteomic Analysis of the Venoms from the Most Dangerous Scorpions in Morocco: Androctonus mauritanicus and Buthus occitanus
by Ines Hilal, Soukaina Khourcha, Amal Safi, Abdelaziz Hmyene, Syafiq Asnawi, Iekhsan Othman, Reto Stöcklin and Naoual Oukkache
Life 2023, 13(5), 1133; - 5 May 2023
Cited by 3 | Viewed by 1979
Morocco is known to harbor two of the world’s most dangerous scorpion species: the black Androctonus mauritanicus (Am) and the yellow Buthus occitanus (Bo), responsible for 83% and 14% of severe envenomation cases, respectively. Scorpion venom is a mixture [...] Read more.
Morocco is known to harbor two of the world’s most dangerous scorpion species: the black Androctonus mauritanicus (Am) and the yellow Buthus occitanus (Bo), responsible for 83% and 14% of severe envenomation cases, respectively. Scorpion venom is a mixture of biological molecules of variable structures and activities, most of which are proteins of low molecular weights referred to as toxins. In addition to toxins, scorpion venoms also contain biogenic amines, polyamines, and enzymes. With the aim of investigating the composition of the Am and Bo venoms, we conducted an analysis of the venoms by mass spectrometry (ESI-MS) after separation by reversed-phase HPLC chromatography. Results from a total of 19 fractions obtained for the Am venom versus 22 fractions for the Bo venom allowed the identification of approximately 410 and 252 molecular masses, respectively. In both venoms, the most abundant toxins were found to range between 2–5 kDa and 6–8 kDa. This proteomic analysis not only allowed the drawing of an extensive mass fingerprint of the Androctonus mauritanicus and Buthus occitanus venoms but also provided a better insight into the nature of their toxins. Full article
(This article belongs to the Special Issue Proteotranscriptomics-Guided Research on Insects and Arachnids Toxins)
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