Placental Development and Function

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Evolutionary Biology".

Deadline for manuscript submissions: closed (20 August 2022) | Viewed by 462

Special Issue Editor

E-Mail Website
Guest Editor
Veterinary Medicine And Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA
Interests: placenta; trophoblast cells; animal models; pregnancy disorders; fetal growth; placental nutrient transport; metabolism; hormones

Special Issue Information

Dear Colleagues,

Normal pregnancy is critically dependent on a proper functioning placenta. Any impairment of placental (trophoblast) cell development or differentiation negatively impacts both the mother and the developing fetus and can lead to intrauterine growth restriction (IUGR). IUGR is a pathological condition in which the fetus never reaches its growth potential. This is associated with altered fetal tissue programming and can have long-lasting consequences for future offspring, also referred to as the Barker hypothesis, or fetal origin of adult diseases, which includes a predisposition to develop cardiovascular disease, diabetes, or infertility. Therefore, understanding trophoblast cell development and differentiation is critical to provide insight into pregnancy complications that adversely affect both mother and fetal health and well-being. Studying placental development and function in humans is greatly hampered by the obvious considerable ethical issues that arise when, for example, obtaining placental tissues during pregnancies. Furthermore, although the placenta has the same critical function in mammals, substantial differences exist in its anatomy, requiring the use of different animal models to provide insight into human placentation.

This Special Issue is open to both original and review articles highlighting the molecular, cellular and genetic regulation underlying trophoblast cell proliferation and differentiation, as well as the use of new and unique in vitro and in vivo models to study placental function in humans and animals.

Prof. Dr. Gerrit Bouma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • placenta
  • trophoblast cells
  • animal models
  • pregnancy disorders
  • fetal growth
  • placental nutrient transport
  • metabolism
  • hormones

Published Papers

There is no accepted submissions to this special issue at this moment.
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