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Life
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Mast Cells in Immune Disfunction and Allergic Diseases
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Mast Cells in Immune Disfunction and Allergic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (16 June 2023) | Viewed by 3209

Special Issue Editors

Dr. Saptarshi Roy

E-Mail Website
Guest Editor
Department of Basic and Translational Sciences, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
Interests: allergy; asthma; inflammation; immune dysregulation; mast cells; MRGPRX2
Dr. Chalatip Chompunud Na Ayudhya

E-Mail Website
Guest Editor
Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand
Interests: mast cells; oral diseases; inflammation; immune dysregulation; MRGPRX2

Special Issue Information

Dear Colleagues,

Mast cells are multifunctional immune sentinel cells, which are well known for their involvement in hypersensitivity and allergic diseases. Mast cells play a crucial role in host defense against parasites and neutralization of snake venom. However, dysregulation of mast cells leads to allergy, asthma and anaphylaxis. Mast cells express the high-affinity IgE receptor FcεRI, which plays a central role in allergy and hypersensitivity reactions. Other than FcεRI, mast cells also express a non-IgE receptor, such as MRGPRX2, which also participates in allergy, pseudoallergy and hypersensitivity reactions. The activation of IgE-dependent and IgE-independent mast cells induces the release of calcium ions from intracellular stores, which triggers subsequent downstream signaling pathways, resulting in the release of preformed and de novo synthesized mediators responsible for allergic reactions.

This Special Issue deals with understanding the immune dysregulation in mast cells that leads to allergy and inflammation, understanding the disease pathogenesis, its clinical implications and treatment. We welcome both reviews and original research articles that cover these urgent issues in the field of mast cell biology.

We welcome articles addressing the following:

  1. Understanding the immune dysregulation in IgE- and non-IgE-mediated mast cell activation.
  2. Disease pathogenesis in allergy and asthma model.
  3. Clinical implications of allergy and inflammation.
  4. Advancements in immunotherapeutic interventions against asthma and allergy.
  5. Transcriptomics and genomics approach to study mast cell dysregulation.

Dr. Saptarshi Roy
Dr. Chalatip Chompunud Na Ayudhya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • FcεRI
  • inflammation
  • immune dysregulation
  • mast cells
  • MRGPRX2

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Published Papers (1 paper)

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10 pages, 681 KiB  
Perspective
Pediatric Angioedema without Wheals: How to Guide the Diagnosis
by Lucia Liotti, Luca Pecoraro, Carla Mastrorilli, Riccardo Castagnoli, Francesca Saretta, Francesca Mori, Stefania Arasi, Simona Barni, Mattia Giovannini, Lucia Caminiti, Michele Miraglia Del Giudice and Elio Novembre
Life 2023, 13(4), 1021; https://doi.org/10.3390/life13041021 - 15 Apr 2023
Cited by 2 | Viewed by 2747
Abstract
Angioedema (AE) is a vascular reaction of subcutaneous and submucosal tissues that identifies various clinical pictures and often is associated with wheals. AE without wheals (AEwW) is infrequent. The ability to distinguish between AEwW mediated by mast cells and bradykinin-mediated or leukotriene-mediated pathways [...] Read more.
Angioedema (AE) is a vascular reaction of subcutaneous and submucosal tissues that identifies various clinical pictures and often is associated with wheals. AE without wheals (AEwW) is infrequent. The ability to distinguish between AEwW mediated by mast cells and bradykinin-mediated or leukotriene-mediated pathways is often crucial for a correct diagnostic–therapeutic and follow-up approach. AEwW can be hereditary or acquired. Factors typically correlated with hereditary angioedema (HAE) are a recurrence of episodes, familiarity, association with abdominal pain, onset after trauma or invasive procedures, refractoriness to antiallergic therapy, and lack of pruritus. The acquired forms of AE can present a definite cause based on the anamnesis and diagnostic tests. Still, they can also have an undetermined cause (idiopathic AE), distinguished according to the response to antihistamine in histamine-mediated and non-histamine-mediated forms. Usually, in childhood, AE responds to antihistamines. If AEwW is not responsive to commonly used treatments, it is necessary to consider alternative diagnoses, even for pediatric patients. In general, a correct diagnostic classification allows, in most cases, optimal management of the patient with the prescription of appropriate therapy and the planning of an adequate follow-up. Full article
(This article belongs to the Special Issue Mast Cells in Immune Disfunction and Allergic Diseases)
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