Macrophages in Human Diseases: From Pathophysiology to Therapeutic Targets
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3137
Special Issue Editors
Interests: cancer immunotherapy; tumor associated macrophages; phagocytosis checkpoint; breast cancer; non-hodgkin lymphoma
Special Issue Information
Dear Colleagues,
As an essential component of innate immune system, macrophages are recognized as a central player in regulating immune responses. They are professional phagocytes, engulfing and digesting foreign substances, damaged cells, and even tumor cells. They are constructors, responsible for wound healing and tissue remodeling. They are also professional antigen presenting cells, together with their role in initiation of inflammation, bridging innate and adaptive immunity. Therefore, it is not surprising that macrophage dysfunction are involved in a plethora of human diseases. There has been explosive growth in macrophage-targeted therapy worldwide during the past decade, showing the great potential of macrophages as a therapeutic target. However, special attention on limiting any possible adverse effect should also be paid due to their broad presence and regulatory effects in nearly every tissue of human body.
This Special Issue is focused on recent advances in the molecular mechanisms of macrophage dysfunction-related diseases, including but not limited to cancers, tumor cell immune escape, cardiovascular disorders, metabolic diseases, neurological diseases, arthritis, inflammatory bowel disease, transplant rejection, and drug-induced diseases, from pathophysiology to therapeutic targets. We invite authors to submit original research articles or review articles relating to the topic.
Dr. Xu Cao
Dr. Hai-Jian Sun
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- macrophages
- microglia
- inflammatory diseases
- innate immunity
- cancer
- metabolic diseases
- immune disorders
