Effects of Exercise on Susceptibility to Environmental and Disease Stressors
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 2555
Special Issue Editor
Special Issue Information
Dear Colleagues,
Exercise is often prescribed as a method to prevent or to treat cardiovascular and metabolic diseases. However, recent data suggest potential mechanisms by which exercise produces substrates (exerkines) which promote crosstalk between all organ systems to maintain health in the face of internal and external stressors. For example, the release of myokines from exercising muscles has been shown to influence the function of the brain, the liver, bone, adipose tissue, blood vessels, the pancreas, and even the skin. Exercise is known to alter gut permeability and intestinal microbiome diversity, with effects on the gut–brain axis and immune function. And the release of heat shock proteins during exercise may increase tolerance to several forms of environmental stress, improve immune function, and stabilize gut permeability. Some, or all, of the above responses influence our susceptibility to cognitive, metabolic, skeletal-muscle, and immunological diseases and tumor growth, as well as preventing cardiovascular diseases.
In this Special Issue, we invite both original research papers and insightful review articles that further address the beneficial effects of exercise. We need to understand not only their mechanisms, but also the specific type, intensity, and frequency of exercise required. While many of the above effects have been found in cell and animal models, more work is needed to confirm the transfer of these results to humans.
Prof. Dr. Suzanne M. Schneider
Guest Editor
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Keywords
- aerobic exercise
- physical activity
- steps per day
- cytokines
- exerkines
- hepatokines
- myokines
- adipokines
- gut–brain axis
- immune function
- obesity
- diabetes
- cardiovascular disease
- hypertension
- osteoporosis
- tumor growth
- cognitive function
- dementia
- depression
- sleep disorders
- hyperthermia
- asthma
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