Immune Activation and Modulation in Neurological Disorders

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (14 July 2023) | Viewed by 2534

Special Issue Editor


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Guest Editor
Department of Microbiology and Immunology, School of Medicine, Taipei, Taiwan
Interests: stroke; brain tumor; autism; microbiome
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Special Issue Information

Dear Colleagues,

The interaction between the immune system and the central nervous system is a dynamic process that contributes to the pathophysiology of neurological disorders. The neuro-immune crosstalk orchestrates a wide range of physiological processes, including tissue homeostasis, repair, and brain function. The aim of the present Special Issue is to collect original articles and reviews aimed at highlighting the role of immunomodulation in the neurological disorders of the central nervous system. How does immune responses and immunomodulation treatment affect neuron and glial cell function, behavior, learning, neurogenesis, and the neuro-immune interaction in central nervous systems are important research topics to understand the pathophysiology of neurological disorders.

Researches describing (i) novel neuro-immune interaction signals and pathways, (ii) neuro-immune interaction mechanisms underlying disease pathogenesis, (iii) the mechanism of therapeutic treatment that affects immune responses in neurological disease, (iv) Actions of cytokines in inflammatory responses in stroke or other types of CNS disorder disease, (v) Regulation of brain injury by the activation of immune responses are the main focus of this Special Issue. This research will elucidate the physiological mechanisms of neurological disorders development and immunomodulation treatment.

Dr. Gilbert Aaron Lee
Guest Editor

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Keywords

  • stroke
  • inflammatory response
  • immune activation
  • immunomodulation
  • the role of cytokine in central nervous system

Published Papers (1 paper)

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Review

15 pages, 883 KiB  
Review
Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
by Edward S. Wickstead, Egle Solito and Simon McArthur
Life 2022, 12(12), 2009; https://doi.org/10.3390/life12122009 - 02 Dec 2022
Cited by 3 | Viewed by 2182
Abstract
Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood–brain barrier endothelial cells. Thus, the roles of these [...] Read more.
Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood–brain barrier endothelial cells. Thus, the roles of these immune-associated receptors are extensive, from governing cellular adhesion and directed migration through chemotaxis, to granule release and superoxide formation, to phagocytosis and efferocytosis. In this review, we will describe the similarities and differences between the two principal pro-inflammatory and anti-inflammatory FPRs, FPR1 and FPR2, and the evidence for their importance in the development of neuroinflammatory disease, alongside their potential as therapeutic targets. Full article
(This article belongs to the Special Issue Immune Activation and Modulation in Neurological Disorders)
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