Heat Shock Proteins in Cancer Treatment
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (22 October 2022) | Viewed by 3362
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer is one of the leading causes of deaths worldwide with around 10 million deaths each year. Due to the growth of populations and their aging, the burden of cancer is expected to grow, in both westernized societies where it is already dominant, but also worldwide. Despite decades of research on the subject, successfully treating cancer patients is still uncertain. Many factors have been shown to increase or decrease cancer patients’ odds of survival. Heat shock proteins (HSPs) are such factors and have been linked to negative outcomes in many cancers. HSPs are protein chaperones that protect cells from various stresses and insults and ensure the stability of the proteome. Tumors are submitted to the stress of their own modified biology and the tumor microenvironment. Furthermore, anticancer treatments represent an additional level of stress for cancer cells. It is therefore unsurprising that many studies conclude that HSPs increase the aggressivity of cancers and their resistance to treatments. This Special Edition focuses on the importance of HSPs in the context of treating cancer. The scope of this Special Edition covers in vitro, in vivo as well as clinical studies, and aims at reporting the latest findings in the following areas:
- Exploring the pathways through which HSPs confer resistance to anticancer therapies.
- Identifying anticancer therapies whose effectiveness is unaffected by HSPs.
- Refining the prognosis value of HSP expression in specific cancer types and anticancer treatment.
- The targeting of HSPs in order to ameliorate the effectiveness of anticancer therapies.
Dr. Sebastien Causse
Guest Editor
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Keywords
- cancer
- anticancer treatment
- heat shock protein
- heat shock response
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