Life | Special Issue : Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition

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Dear Colleagues,

The incidence of chronic inflammatory skin diseases, as well as their comorbidities, is constantly growing. Diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic urticaria are characterized by a complex etiopathogenesis involving genetic susceptibility, environmental factors, immunological dysfunction, and alterations of the epidermal barrier. Their severe forms can be enormously disabling and have a negative impact on the quality of life of the affected patients. The clinical course is chronic–remitting–relapsing, with, therefore, the indispensable need to ensure safe and effective therapies. The study of the complex pathogenetic mechanisms will allow the identification of new therapeutic targets, as well as novel biomarkers with diagnostic significance and predictive value for disease severity and response to therapy.

Dr. Annunziata Raimondo
Guest Editor

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Published Papers (1 paper)

Research

20 pages, 1941 KiB

Open AccessArticle

Oral Lesions and Oral Health-Related Quality of Life in Adult Patients with Psoriasis: A Retrospective Chart Review

by Federica Di Spirito, Annunziata Raimondo, Maria Pia Di Palo, Stefano Martina, Mario Fordellone, Donato Rosa, Massimo Amato and Serena Lembo

Life 2024, 14(3), 347; https://doi.org/10.3390/life14030347 - 7 Mar 2024

Viewed by 814

Abstract

Psoriasis is a widespread chronic inflammatory skin disease, that negatively affects physical and emotional well-being and quality of life, as shown by the generally low Dermatology Life Quality Index (DLQI). Psoriasis is burdened by associated comorbidities and some patients manifest concurrent oral lesions, although the existence of oral psoriasis remains controversial. Psoriasis-specific and nonspecific oral lesions and Oral Health-Related Quality of Life (OHRQoL), self-assessed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire, were retrospectively reviewed in adult untreated psoriasis patients with ≥15 teeth, who were non-smokers and had no dental or periodontal infections. Sample (age, gender, comorbidities) and descriptive variables (Body Surface Area-BSA, Psoriasis Area and Severity Index-PASI, Dermatology Life Quality Index-DLQI, severity of psoriasis, distribution of lesions and predominant involvement, years since diagnosis) were correlated with DLQI and OHIP-14 and compared by baseline DLQI and OHRQoL classes. Charts from 90 participants were included. No oral lesions were detected, and excellent/good OHRQoL was found in 94% of the participants. DLQI scores displayed positive significant associations with PASI and BSA, while OHIP-14 with hypertension and IMID, and age. PASI and BSA were significantly higher in participants with DLQI > 10 and also differed significantly among OHQRoL ranks, as well as mucosal involvement and comorbidities. Specifically, among subjects revealing an Excellent OHQRoL, 92.6% were non-IMID, 75% non-hypertensive, 89.7% non-diabetic subjects, 86.8% of non CVD-subjects. Full article

(This article belongs to the Special Issue Immuno-Pathogenesis Skin Diseases: Novel Molecular Targets and Biomarkers: 2nd Edition)

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