Update on Clinical Pharmacology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 661

Special Issue Editor


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Guest Editor
Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Interests: drug delivery system; clinical pharmacology; pharmacokinetics; disease models; new drug development; clinical trials; exosome; clinical toxicology; therapeutic drug monitoring; drug assays method; development in biological fluids
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Special Issue Information

Dear Colleagues,

Clinical pharmacology is a branch of biomedical science that studies the clinical use and effects of drugs on their targets in living systems, along with their discovery, and the biological functions related to these chemicals. This Special Issue, “Update on Clinical Pharmacology”, will feature in Life, an international, peer-reviewed, and open access journal. It aims to cover various aspects of pharmacological applications, such as drug efficacy, drug safety (adverse drug reactions), new drug development, clinical trials, therapeutic drug monitoring, pharmacodynamics, pharmacokinetics, pharmacoeconomics, pharmacovigilance and clinical toxicology. Original research, methodology papers, short reports, reviews and commentaries in all areas of drug experience in humans will be considered.

Prof. Dr. Ju-Seop Kang
Guest Editor

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Keywords

  • drug efficacy and drug safety
  • new drug development
  • therapeutic drug monitoring
  • clinical trials
  • pharmacodynamic and pharmacokinetics
  • pharmacovigilance
  • clinical toxicology

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Published Papers (1 paper)

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Research

13 pages, 1650 KB  
Article
Safety, Pharmacokinetics, and Food Effect of the RORα Agonist TB-840, a Novel Candidate for Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Randomized First-in-Human Study in Healthy Volunteers
by Inyoung Hwang, Shi-Ra Lee, Heung Jae Kim, Yun Kim and Sang Won Lee
Life 2025, 15(9), 1410; https://doi.org/10.3390/life15091410 - 7 Sep 2025
Viewed by 420
Abstract
TB-840 is a novel RORα agonist being developed by Therasid Bioscience Inc. for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending doses of TB-840 in healthy adult volunteers. In the [...] Read more.
TB-840 is a novel RORα agonist being developed by Therasid Bioscience Inc. for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending doses of TB-840 in healthy adult volunteers. In the single ascending dose part, 64 participants were randomized to receive TB-840 (12.5–200 mg) or placebo. In the food effect part, 6 participants received a single 200 mg dose under fasted and fed conditions in a crossover design. TB-840 was rapidly absorbed (median Tmax 1.7–2.5 h) with a mean half-life of 4.8–9.7 h. Systemic exposure increased dose-proportionally across the studied dose range. A high-fat meal delayed absorption and increased the systemic exposure. TB-840 was well-tolerated, with no serious adverse events reported. These results support the continued development of TB-840 as a potential treatment for MASH. Further studies are warranted to evaluate its efficacy and safety in the target patient population (ClinicalTrials.gov identifier: NCT05045534). Full article
(This article belongs to the Special Issue Update on Clinical Pharmacology)
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