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Life
Special Issues
Development of Anticancer and Antiviral Drugs
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Development of Anticancer and Antiviral Drugs

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (23 June 2023) | Viewed by 4983

Special Issue Editors

Prof. Dr. Ming-Hon Hou

E-Mail Website
Guest Editor
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
Interests: DNA-binding drug design; anticancer drug targeting DNA or RNA; coronavirus nucleocapsid protein; antiviral drug development; structural biology; virology; X-ray crystallography; biophysical techniques
Special Issues, Collections and Topics in MDPI journals
Dr. Roshan Satange

E-Mail Website
Guest Editor
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
Interests: nucleic acids structures and functions; DNA mismatches; DNA-binding drugs; anticancer drug development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Technological advances in recent years have enabled significant progress in the development of drugs for various diseases. However, cancer and viral diseases remain the two major categories of human diseases that require special attention in drug development. Many drugs have been approved for clinical use to treat cancers and viral infections, but none of these drugs are without toxicities or other side effects. In addition, the heterogeneity of cancers and drug resistance pose another problem for currently available drugs. Therefore, the continuous search for new candidates that can be used against cancer and viral diseases is necessary. In drug discovery, initial laboratory studies such as identification of novel druggable targets or potential lead molecules, screening, and evaluation of druggable properties of small molecule compounds, etc. play an important role. The advent of new molecular and cell biology techniques, bioinformatics, genomics, and other structural and functional methods have opened new opportunities for anticancer and antiviral drug development. With this Special Issue, we aim to provide an overview of recent advances in cancer and antiviral drug development to a broader academic and scientific community.

We invite you to contribute original research articles, reviews, clinical study results, molecular and bioinformatics analyses, and structural and biophysical studies on anticancer and antiviral drug development that highlight new advances in the field.

We look forward to receiving your submission.

Prof. Dr. Ming-Hon Hou
Dr. Roshan Satange
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancers
  • viral diseases
  • drug development
  • anticancer drugs
  • antiviral drugs
  • drug discovery
  • structure-based drug designing
  • molecular biology
  • cell biology

Published Papers (2 papers)

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Research

15 pages, 1811 KiB  
Article
Comprehensive Phytochemical Analysis of Various Solvent Extracts of Artemisia judaica and Their Potential Anticancer and Antimicrobial Activities
by Merajuddin Khan, Mujeeb Khan, Khaleel Al-hamoud, Syed Farooq Adil, Mohammed Rafi Shaik and Hamad Z. Alkhathlan
Life 2022, 12(11), 1885; https://doi.org/10.3390/life12111885 - 14 Nov 2022
Cited by 2 | Viewed by 1303
Abstract
Solvents play an important role in the extraction process by considerably affecting the amount and nature of secondary metabolites of medicinal plants. Thus, the effect of solvents must be investigated to obtain desired biological properties of plant extracts. In the current study, we [...] Read more.
Solvents play an important role in the extraction process by considerably affecting the amount and nature of secondary metabolites of medicinal plants. Thus, the effect of solvents must be investigated to obtain desired biological properties of plant extracts. In the current study, we extracted aerial parts of Artemisia judaica, native to Saudi Arabia, in three different solvents, including methanol (MeOH), hexane (Hex), and chloroform (Chl). Obtained extracts from the aerial parts of A. judaica were analysed by GC–MS and GC–FID techniques, which resulted in the identification of 46, 18, and 17 phytoconstituents from the Hex, Chl, and MeOH extracts, respectively. All the extracts contain oxygenated terpenes, aliphatic hydrocarbons, and aromatics as major classes of compounds in varying amounts. Among the various phytoconstituents identified, piperitone was the dominant compound and was found in all the extracts in different amounts, specifically, 28.8, 26.1, and 20.1% in the Chl, MeOH, and Hex extracts, respectively. Moreover, all these extracts (Chl, MeOH, and Hex) were tested for the antimicrobial properties on both Gram-positive and negative bacteria as well as for their anticancer properties on four different cell lines including HepG2, DU145, Hela, and A549. Among the different extracts, the Hex and Chl extracts demonstrated identical antimicrobial properties, while the Chl extract showed superior anticancer properties when compare to the other extracts. The higher biological properties of Chl extracts including both antimicrobial and anticancer activities may be attributed to the presence of large amounts of piperitone and/or santonin, which are distinctly present in excess amounts in the Chl extract. Full article
(This article belongs to the Special Issue Development of Anticancer and Antiviral Drugs)
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19 pages, 5915 KiB  
Article
Green Synthesis and Anticancer Potential of 1,4-Dihydropyridines-Based Triazole Derivatives: In Silico and In Vitro Study
by Sabera Bijani, Danish Iqbal, Sheefa Mirza, Vicky Jain, Sadaf Jahan, Mohammed Alsaweed, Yahya Madkhali, Suliman A. Alsagaby, Saeed Banawas, Abdulrahman Algarni, Faris Alrumaihi, Rakesh M. Rawal, Wael Alturaiki and Anamik Shah
Life 2022, 12(4), 519; https://doi.org/10.3390/life12040519 - 31 Mar 2022
Cited by 7 | Viewed by 2609
Abstract
A library of 1,4-dihydropyridine-based 1,2,3-triazol derivatives has been designed, synthesized, and evaluated their cytotoxic potential on colorectal adenocarcinoma (Caco-2) cell lines. All compounds were characterized and identified based on their 1H and 13C NMR (Nuclear Magnetic Resonance) spectroscopic data. Furthermore, molecular [...] Read more.
A library of 1,4-dihydropyridine-based 1,2,3-triazol derivatives has been designed, synthesized, and evaluated their cytotoxic potential on colorectal adenocarcinoma (Caco-2) cell lines. All compounds were characterized and identified based on their 1H and 13C NMR (Nuclear Magnetic Resonance) spectroscopic data. Furthermore, molecular docking of best anticancer hits with target proteins (protein kinase CK2α, tankyrase1, and tankyrase2) has been performed. Our results implicated that most of these compounds have significant antiproliferative activity with IC50 values between 0.63 ± 0.05 and 5.68 ± 0.14 µM. Moreover, the mechanism of action of most active compounds 13ab′ and 13ad′ suggested that they induce cell death through apoptosis in the late apoptotic phase as well as dead phase, and they could promote cell cycle arrest at the G2/M phase. Furthermore, the molecular docking study illustrated that 13ad′ possesses better binding interaction with the catalytic residues of target proteins involved in cell proliferation and antiapoptotic pathways. Based on our in vitro and in silico study, 13ad′ was found to be a highly effective anti-cancerous compound. The present data indicate that dihydropyridine-linked 1,2,3-triazole conjugates can be generated as potent anticancer agents. Full article
(This article belongs to the Special Issue Development of Anticancer and Antiviral Drugs)
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