Pathogenic Mechanisms, Diagnosis, and Treatment of Hypertension: Insights and Implications

Dear Colleagues

More than one billion people worldwide suffer from hypertension, a leading cause of cardiovascular disease and the primary risk factor for cardiovascular mortality. In the U.S., approximately 670,000 deaths yearly are attributed to hypertension as a primary or contributing cause. Unfortunately, achieving adequate blood pressure control poses a significant challenge, with only around 25% of hypertensive patients in the U.S. attaining normal blood pressure levels through medication regimens. Moreover, discontinuing antihypertensive medications is not an option, even for patients with controlled blood pressure, as sustained elevation tends to recur. These alarming statistics underscore the critical need to identify unknown mechanisms involved in hypertension’s pathogenesis and design improved medications for its treatment. The pathogenesis of hypertension involves an intricate interplay among various systemic regulations within the body, including the renin–angiotensin–aldosterone system (RAAS), vasculature system, renal sodium-fluid regulation system, sympathetic nervous system, metabolic regulation system, immune system, genetic factors, lifestyle factors, and more. This multidimensional perspective highlights the urgency for comprehensive research aimed at unraveling the complexities of hypertension’s mechanisms. Efforts in this direction are essential for the development of advanced diagnostic tools and therapeutic interventions that can effectively address this widespread health challenge. In light of these imperative research needs, we cordially invite the submission of research and review papers contributing to our understanding of hypertension’s pathogenesis and proposing innovative solutions for its diagnosis and treatment. Researchers and experts in the field are encouraged to share their findings and insights, fostering a collaborative effort to advance our capabilities in combating this global health crisis.

Dr. Shengyu Mu
Dr. Sankar Devarajan
Guest Editors

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