Urinary Microbiome and Genitourinary System Disorders: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 1163

Special Issue Editors


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Guest Editor
Nij Smellinghe Hospital, Compagnonsplein 1, 9202 NN Drachten, The Netherlands
Interests: functional urology; microbiome; neuromodulation
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Guest Editor
Department of Urology, Maastricht University, Maastricht, The Netherlands
Interests: neuro-urology; endourology; urologic surgical procedures; urology; neuromodulation; urinary incontinence; pelvic floor; prostate cancer; urodynamics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Editors are grateful to the many researchers who contributed to the success of the first volume of this issue (https://www.mdpi.com/journal/life/special_issues/Urinary_Microbiome). We are very pleased to announce the second volume of our Special Issue “Urinary Microbiome and Genitourinary System Disorders”.

The urinary microbiome is a newly introduced concept that has attracted the attention of medical researchers. Until recently, the urine of healthy individuals was assumed to be sterile. However, the improvement in bacterial detection methods has debunked this assumption. Recent studies have shown that the bladder contains microbiomes, which are not detectable under standard conditions. Analysis using 16S rRNA sequencing and expanded quantitative urine cultures has provided evidence for the presence of live bacteria in urine. Furthermore, the development of metagenomic sequencing has revealed a unique urinary microbiota that is not detectable using standard culture protocols.

Since its a recent introduction, researchers have conducted many fruitful studies on this phenomenon, changing our perspective toward the role of bacteria in the urinary tract and our perception of genitourinary system health.

A deeper understanding of the urinary microbiome can help us to develop more efficient methods for restoring the microbiota to a healthy composition and providing symptom relief. The modification of the urinary microbiome without antibiotic use can be a possible avenue for future research.

Dr. Mohammad Sajjad Rahnama'i
Prof. Dr. Philip Van Kerrebroeck
Guest Editors

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Keywords

  • microbiome
  • microbiota
  • bacteria
  • 16s-RNA sequencing
  • bladder
  • urinary tract infection
  • urgency
  • incontinence
  • lower urinary tract symptoms (LUTS)

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Published Papers (2 papers)

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20 pages, 770 KiB  
Systematic Review
Exploring Childhood Lower Urinary Tract Symptoms (LUTS), Urinary Tract Infections (UTIs) and the Microbiome—A Systematic Review
by Mauro Van den Ende, Laure Van de Steen, Karel Everaert, François Hervé and George Bou Kheir
Life 2025, 15(5), 730; https://doi.org/10.3390/life15050730 (registering DOI) - 30 Apr 2025
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Abstract
Pediatric lower urinary tract symptoms (LUTS) are influenced by age and coexist with nocturnal enuresis (NE) and bladder-bowel dysfunction (BBD). Urinary tract infections (UTIs) are common and linked to LUTS, though the causal relationship remains unclear. This systematic review aims to analyze microbiome [...] Read more.
Pediatric lower urinary tract symptoms (LUTS) are influenced by age and coexist with nocturnal enuresis (NE) and bladder-bowel dysfunction (BBD). Urinary tract infections (UTIs) are common and linked to LUTS, though the causal relationship remains unclear. This systematic review aims to analyze microbiome alterations in pediatric LUTS and UTIs. Methods: A systematic review was conducted following PRISMA guidelines. PubMed, Embase, and CINAHL databases were searched for studies analyzing gut and urinary microbiomes in pediatric patients with LUTS and UTIs. Quality assessment was performed using the QUADOMICS checklist. Results: Nine studies published between 2018 and 2024 were included; seven out of nine studies employed prospective designs. Six hundred nineteen patients (44.3% pathology groups, 55.7% controls) were analyzed, with microbiome sequencing performed on stool samples in four studies and urine samples in five studies. UTIs and BBD were associated with reduced alpha diversity and distinct bacterial compositions, while beta diversity analyses revealed distinct clustering of microbiome compositions between affected and healthy groups. The gut microbiome of UTI patients showed alterations in Actinobacteria and Proteobacteria abundance, while voiding dysfunction (VD) was linked to the presence of Fusobacterium nucleatum, Clostridium difficile, and Bacteroides clarus without significant VDSS correlation. Conclusion: This systematic review reveals microbial alterations in pediatric LUTS and UTIs, with lower urinary diversity in UTI patients and sex-specific differences post-puberty. Microbiome-based interventions may offer novel therapeutic strategies for LUTS and UTIs. Full article
(This article belongs to the Special Issue Urinary Microbiome and Genitourinary System Disorders: 2nd Edition)
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19 pages, 733 KiB  
Systematic Review
The Role of Urinary Microbiome Analysis in the Diagnostic Approach and Management of Urinary Incontinence: A Systematic Review
by Pouyan Shaker, Zohreh Roshani, Ehsan Timajchi, Zahra Sharifi, Sarah Nikzadfar Goli, Behrooz Broumand and Mohammad Ali Shafiee
Life 2025, 15(2), 309; https://doi.org/10.3390/life15020309 - 17 Feb 2025
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Abstract
Urinary incontinence (UI) is a significant global health issue that impacts mainly middle-aged women, severely affecting their quality of life. Emerging research highlights the urinary microbiome’s complex role in the etiology and management of UI, with microbial dysbiosis potentially influencing symptom severity and [...] Read more.
Urinary incontinence (UI) is a significant global health issue that impacts mainly middle-aged women, severely affecting their quality of life. Emerging research highlights the urinary microbiome’s complex role in the etiology and management of UI, with microbial dysbiosis potentially influencing symptom severity and treatment outcomes. This systematic review aimed to evaluate the current evidence on the urinary microbiome’s role in diagnosing and managing UI, focusing on variations in microbial composition across UI subtypes. We identified 21 studies, mostly employing 16S rRNA sequencing to characterize urinary microbiota and their associations with various UI subtypes, including urgency urinary incontinence (UUI), overactive bladder (OAB), and stress urinary incontinence (SUI). The findings revealed distinct microbial patterns, such as reduced Lactobacillus levels and increased Gardnerella prevalence, particularly in UUI. Altered microbiome profiles correlated with symptom severity, with reduced Lactobacilli suggesting a protective role in maintaining urinary health. Specific microbial species, including Actinotignum schaalii and Aerococcus urinae, emerged as potential biomarkers for UI diagnosis. Despite promising findings, limitations such as small sample sizes, variability in microbiome profiling methods, and insufficient causal evidence underscore the need for further research. Full article
(This article belongs to the Special Issue Urinary Microbiome and Genitourinary System Disorders: 2nd Edition)
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