Insights into Obstructive Sleep Apnea

Dear Colleagues,

This Special Issue focuses on Obstructive Sleep Apnea (OSA), a prevalent and chronic disorder characterized by repetitive apneas and hypopneas during sleep. It is associated with increased morbidity and mortality and is considered a potential etiological factor for cardiometabolic diseases such as hypertension, diabetes mellitus, stroke, insulin resistance, and atrial fibrillation. Diagnosing OSA is complex, requiring overnight sleep monitoring through polysomnography (PSG). However, PSG alone may not fully demonstrate individual susceptibility to systemic effects. Thus, the inclusion of biomarkers and vascular parameters can improve prognosis prediction and treatment response. Serum and salivary biomarkers offer promising tools for ongoing disease severity monitoring.

Various treatment options for OSAS, including continuous positive airway pressure (CPAP), mandibular advancement devices, upper airway (UA) surgery, and hypoglossal nerve stimulation, mainly focus on improving the impaired UA anatomy. While CPAP remains the "gold standard," its compliance rate is low, and knowledge gaps exist regarding targeted therapy for OSAS. Identifying clinical phenotypes and predictive factors is vital to enable personalized treatment for this complex condition.

This Special Issue aims to highlight the recent advances and new perspectives on OSA diagnosis, personalized treatment strategies, and patient follow-up. The goal is to enhance our understanding of OSA and ultimately improve patient outcomes and quality of life. Authors are encouraged to contribute research on clinical phenotypes, predictive factors, and innovative treatments, ultimately striving to improve the management and outcomes of OSAS patients.

Prof. Dr. Kimberly A. Hardin
Guest Editor

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