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LabMed
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Laboratory Medicine in Hematology
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Laboratory Medicine in Hematology

A Special Issue of LabMed (ISSN 2813-9038).

Deadline for manuscript submissions: 30 November 2026 | Viewed by 5894

Editor

Dr. Glen L. Hortin

E-Mail Website1 Website2
Guest Editor
1. Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA
2. Department of Oncologic Science, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Interests: clinical chemistry; clinical pathology

Special Issue Information

Dear Colleagues,

Laboratory medicine is crucial for diagnosing and monitoring hematological disorders and guiding therapeutic decisions. LabMed is pleased to announce the launch of this Special Issue, which is dedicated to the study of hematology. We welcome the submission of papers broadly related to laboratory investigations in this area, including coagulation, disorders of platelets, red cells, and leukocytes, and hematological malignancies. The development of innovative molecular tests and laboratory technologies helps provide greater insights into clinical disorders, and the publication of new findings can facilitate the implementation of these tools. Additionally, numerous therapeutic advances, such as new anticoagulants, therapeutic monoclonal antibodies, and chimeric antigen receptor T-cell therapies (CAR-T), are enhancing the efficacy of laboratory evaluations. 

LabMed is a new open access journal that rapidly distributes research that can be accessed without a subscription. The journal’s peer review process is fast, and editing support is available.

Dr. Glen L. Hortin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. LabMed is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hematology
  • coagulation
  • anemia evaluation
  • platelet disorders
  • evaluation of hematological malignancies
  • laboratory evaluation of thrombosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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24 pages, 1140 KB  
Article
Pre-Operational Validation of a Deviation-Ready QMS for Source Plasma Centers: Readiness Metrics and Hematology Supply Implications
by Ankush U. Patel, Ryan McDougall and Samir Atiya
LabMed 2026, 3(1), 2; https://doi.org/10.3390/labmed3010002 - 14 Jan 2026
Viewed by 1407
Abstract
Source plasma centers sustain hematology therapeutics by safeguarding testing, traceability, and cold-chain integrity before fractionation. Despite regulatory requirements (21 CFR 606/640; EU Directive 2005/62/EC), published pre-operational validation frameworks demonstrating deviation-readiness before first collections remain sparse. We conducted a simulation-based pre-operational validation of an [...] Read more.
Source plasma centers sustain hematology therapeutics by safeguarding testing, traceability, and cold-chain integrity before fractionation. Despite regulatory requirements (21 CFR 606/640; EU Directive 2005/62/EC), published pre-operational validation frameworks demonstrating deviation-readiness before first collections remain sparse. We conducted a simulation-based pre-operational validation of an electronic quality management system (eQMS) with an Incident → Deviation → Corrective Action and Preventive Action (CAPA) pathway at a new source plasma center, performing 20 chairside mock runs, 3 freezer-alarm drills, and a document-control stress test. Primary endpoints were anomaly rate, alarm-response time relative to a 15 min service-level agreement (SLA), and deviation-closure SLA compliance. Analyses were descriptive and designed to demonstrate system functionality, not long-term process stability. Minor anomalies occurred in 6/20 mock runs (30.0%; 95% CI 11.9–54.3); no major/critical events were observed (0/20; 95% CI 0–16.8). Deviation-closure SLAs were met in 6/6 tests (100%; 95% CI 54.1–100). Alarm-response times averaged 7.0 min (SD 1.0; range 6–8 min; 95% CI 4.5–9.5), and all drills met the 15 min vendor SLA, illustrating a preliminary readiness margin (Cpu ≈ 2.7) rather than a statistically stable capability estimate. Simulation-based pre-operational validation produced inspection-ready documentation and quantitative acceptance criteria aligned to U.S./EU expectations, supporting reproducible multi-site deployment. By protecting cold-chain integrity and traceability before first collections, the validated QMS helps preserve supply reliability for plasma-derived therapeutics central to hematology care and establishes the measurement infrastructure for post-operational performance validation. Full article
(This article belongs to the Special Issue Laboratory Medicine in Hematology)
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Review

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27 pages, 6467 KB  
Review
Hemoglobin—A Review of Structure, Mechanisms and Analysis in the Clinical Diagnostic Laboratory
by Neil S. Harris, Paul Boothe, Hanna Mbatia, William E. Winter and Maximo J. Marin
LabMed 2026, 3(2), 15; https://doi.org/10.3390/labmed3020015 - 31 May 2026
Cited by 1 | Viewed by 3173
Abstract
This review focuses on the analysis of hemoglobin in the clinical laboratory with an emphasis on the structure–function relationships of hemoglobin and the various methodologies used for its measurement. In clinical laboratories, hemoglobin analysis may take on many forms. These include measuring the [...] Read more.
This review focuses on the analysis of hemoglobin in the clinical laboratory with an emphasis on the structure–function relationships of hemoglobin and the various methodologies used for its measurement. In clinical laboratories, hemoglobin analysis may take on many forms. These include measuring the concentration of hemoglobin, as well as determining the percentage of oxyhemoglobin, deoxyhemoglobin and dyshemoglobins such as carboxyhemoglobin. There are also techniques available to estimate the oxygen affinity of hemoglobin. Hemoglobin separation techniques by means of electrophoresis or chromatography are essential in the diagnosis of hemoglobinopathies (such as sickle cell anemia) and thalassemias, where there is an imbalance in globin chain synthesis. Hemoglobin contains four globin subunits, which create a unique quaternary structure in which the oxygen affinity can be changed by allosteric modifiers, including oxygen itself. The heme iron-containing tetrapyrrole ring not only carries oxygen; it also controls the binding of oxygen to the other globin subunits. The organization and regulation of the globin genes are discussed to provide essential biological context for informed interpretation of clinical test results. Building on this foundation, selected hemoglobinopathies and thalassemias are highlighted to further illustrate structure–function relationships and their implications for diagnostic testing. However, an exhaustive analysis of hemoglobinopathies is beyond the intended scope of this review, which is not meant to be all-encompassing, as these subjects are extensively addressed in many textbooks and published articles and reviews. Full article
(This article belongs to the Special Issue Laboratory Medicine in Hematology)
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