Personalized Medicine in Cardiovascular Patients: From Basic Concepts to the Clinical Challenges

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 1355

Special Issue Editor

1. Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11220, Taiwan
2. Institute of Clinical Medicine and Cardiovascular Research Institute, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
Interests: cardiac arrhythmias; electrophysiology; biological pacemakers; artificial intelligence

Special Issue Information

Dear Colleagues,

The individual differences in the genome and the environment bring about variable risks with regard to disease onset, therapeutic response, and prognosis in patients with cardiovascular diseases.

We hope to elucidate the novel mechanisms and relevant biomarkers to identify the patients at risk for rapid disease progression or poor therapeutic response. Therefore, personalized designs could be made for the diagnosis and treatment of cardiovascular diseases.

Rapid progression in the areas of the genome, omics, images, and physiology real-time monitoring all give us the chance to identify new mechanisms or biomarkers to identify personal variation for personalized medicine. However, the integration of these big data and their correlation to clinical practice and outcomes remains challenging. A translational study to prove the clinical benefits is a critical step before the personalized strategy is used in guiding clinical practice.

We are soliciting and will publish papers related to new mechanisms and specific biomarkers, and which are suggestive of the translational potential or could identify patients at risk for disease onset, poor therapeutic response, or prognosis in cardiovascular diseases.

Dr. Yu-Feng Hu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • personalized medicine
  • cardiovascular diseases
  • genome
  • omics
  • images
  • physiology monitoring
  • mechanisms
  • biomarker

Published Papers (1 paper)

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Research

16 pages, 3077 KiB  
Article
Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study
by Zorica Savovic, Bozidar Pindovic, Maja Nikolic, Ivan Simic, Goran Davidovic, Vladimir Ignjatovic, Jelena Vuckovic, Nenad Zornic, Tamara Nikolic Turnic, Vladimir Zivkovic, Ivan Srejovic, Sergej Bolevich, Vladimir Jakovljevic and Violeta Iric Cupic
J. Pers. Med. 2023, 13(7), 1050; https://doi.org/10.3390/jpm13071050 - 26 Jun 2023
Viewed by 953
Abstract
(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the [...] Read more.
(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of myocardial infarction (MI). (2) Methods: This prospective observational case-control study included 40 consecutive STEMI and 39 NSTEMI patients hospitalized in the coronary care unit of the cardiology clinic at the Kragujevac Clinical Center, Serbia, between 1 January 2016 and 1 January 2017. Blood samples were collected from all patients for measuring cardio-specific enzymes at admission and 12 h after admission to evaluate systemic oxidative stress biomarkers and the activity of antioxidant enzymes. (3) Results: In this study, participants were predominately female (52%), with a mean age of 56.17 ± 1.22 years old in the STEMI group and 69.17 ± 3.65 in the non-STEMI group. According to the Killip classification, the majority of patients (>50%) were at the second and third level. We confirmed the elevation of superoxide anion radicals in the non-STEMI group 6 h after admission in comparison with the STEMI and CTRL groups, but levels had decreased 12 h after admission. Levels of hydrogen peroxide were statistically significantly increased in the NSTEMI group. A positive correlation of superoxide anion radicals and levels of troponin I at admission was observed (r = 0.955; p = 0.045), as well as an inverse correlation between reduced glutathione and levels of NT-pBNP measured 6 h after admission (r = −0.973; p = 0.027). (4) Conclusions: We confirmed that superoxide anion radicals and reduced glutathione observed together with hs-troponin I at admission and NT-pBNP during hospital treatment could be predictors of ST evolution. Full article
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