Rehabilitation for Neurological, Psychiatric and Psychological Disorders: A Current Challenge to Evaluate and Treat Traditional Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1586

Special Issue Editors

Special Issue Information

Dear Colleagues,

Neurological, psychiatric and psychological diseases are becoming more and more widespread all over the world, determining difficult conditions of disability due to cognitive impairment and behavioural disorders.

This Special Issue aims to collect valuable scientific contributions to improve the evaluation and treatment of these disorders and to build new rehabilitation strategies for these patients. Therefore, any advancement for treating these patients is desirable, ranging from new evaluation tools to new and traditional drugs, and from physical activity to rehabilitative protocols. Original articles and reviews are welcome to pursue this goal.

Dr. Giacomo Farì
Dr. Andrea Bernetti
Guest Editors

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Keywords

  • rehabilitation
  • neurodegenerative disease
  • behavioural disorders
  • evaluation tools
  • physical activity
  • new drugs

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Published Papers (1 paper)

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8 pages, 2415 KiB  
Case Report
The Synergistic Effects of Incobotulinum Toxin and Physiotherapy in a Rare Case of Paraparesis in a 7-Year-Old Affected by Klippel–Feil Syndrome Related to an MYH3 Gene Mutation: A Case Report
by Maurizio Ranieri, Mariagrazia Riccardi, Maria Vittoria Raele, Giacomo Farì, Marisa Megna and Riccardo Marvulli
J. Pers. Med. 2024, 14(11), 1073; https://doi.org/10.3390/jpm14111073 - 24 Oct 2024
Viewed by 1162
Abstract
Background: Klippel–Feil disease is a condition characterized by a defect in the spine, consisting of the fusion or non-separation of two or more vertebrae of the cervical tract. It affects 1 in every 50,000 newborns, and the pathogenesis remains unknown to date, although [...] Read more.
Background: Klippel–Feil disease is a condition characterized by a defect in the spine, consisting of the fusion or non-separation of two or more vertebrae of the cervical tract. It affects 1 in every 50,000 newborns, and the pathogenesis remains unknown to date, although the role of certain genes that are involved in segmentation processes is being studied. A single case of a genetic Myosin Heavy Chain 3 (MYH3) mutation is described here. Affected patients are typically distinguished by a relatively short neck, which leads to limited mobility, a low hairline, and obesity; they may also experience various other health issues. The common occurrence of comorbidities further diminishes the quality of life of these young individuals. Methods: The following case report describes the synergistic effect of Incobotulinum toxin type A and physiotherapy in a 7-year-old patient with MYH3 mutation-related Klippel–Feil syndrome (KFS) complicated by bilateral paraplegia to improve the spasticity condition of the lower limbs. To assess improvements over time, the patient underwent rating scales to determine spasticity (Modified Ashworth Scale: MAS), the neck’s range of motion (ROM), and muscle tone by using MyotonPro®. Specifically, measurements were taken on the day of the first medical examination (T0), the month after the injection and the startup of therapeutic exercise (T1), at three months (T2), and then once a month for a total of 6 months (T3, T4, and T5). Results: This therapeutic approach resulted in highly satisfactory outcomes for the child’s well-being, which was maintained until the sixth month and was accompanied by a complete absence of any side effects. Full article
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