Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment

A special issue of Journal of Nanotheranostics (ISSN 2624-845X).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2375

Special Issue Editor

Special Issue Information

Dear Colleagues,

Recently, several nanomaterials have appeared as valuable tools for clinical applications in the areas of drug delivery, diagnosis, bioimaging, and biosensing. Among them, carbon-based nanomaterials have gained importance in biomedicine with their unique physio-chemical properties, excellent optical properties, and high mechanical strength. These nanomaterials not only allow the diagnosis and detection at the molecular scale, but also provide specificity and sensitivity in drug delivery and bioimaging. I am pleased to invite you to submit articles discussing the use of carbon-based nanomaterials (carbon nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) alone, or the combination of them with functionalized molecules (drugs, natural compounds, biomolecules, polymers, metal nanoparticles, etc.), for application in drug delivery, as a sensing material and in theranostics. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Carbon nanomaterials;
  • Drug delivery;
  • Bioimaging;
  • Biosensing;
  • Cancer therapy.

I look forward to receiving your contributions.

Prof. Dr. Jyh-Ping Chen
Guest Editor

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Keywords

  • carbon nanotubes
  • graphene
  • graphene oxide
  • carbon quantum dots
  • nanodiamond
  • cancer therapy
  • theranostics
  • biosensing
  • drug delivery

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Published Papers (1 paper)

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Research

16 pages, 3972 KiB  
Article
Graphene Oxide Chemical Refining Screening to Improve Blood Compatibility of Graphene-Based Nanomaterials
by Fabio Pieretti, Alessandro Moretto, Emanuele Papini and Regina Tavano
J. Nanotheranostics 2024, 5(1), 13-28; https://doi.org/10.3390/jnt5010002 - 20 Feb 2024
Viewed by 1534
Abstract
Graphene oxide (GO) nanoparticles, due to their favorable water solubility, compared to graphene (GA), are a hot research topic in biomedical and pharmaceutical research. However, GO clinical translation may be complicated by its high surface/volume ratio enhancing the interaction with human blood components. [...] Read more.
Graphene oxide (GO) nanoparticles, due to their favorable water solubility, compared to graphene (GA), are a hot research topic in biomedical and pharmaceutical research. However, GO clinical translation may be complicated by its high surface/volume ratio enhancing the interaction with human blood components. In fact, GO’s bi-dimensional nature and strong negative charge may lead to severe biological effects, such as thrombogenicity and immune cell activation. This study explores the impact of further GO surface chemical modulation on major adverse effects: blood plasma coagulation and hemolysis. To this aim, we refined GO nanoparticles by fine-tuned reduction chemistry, esterification and introduction of negative or positive charges. With this approach, we were able to mitigate plasma coagulation and hemolysis at variable degrees and to identify GO derivatives with improved biocompatibility. This opens the door to the progress of graphene-based nanotheranostic applications. Full article
(This article belongs to the Special Issue Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment)
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