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Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment
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Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment

A special issue of Journal of Nanotheranostics (ISSN 2624-845X).

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 7062

Special Issue Editor

Prof. Dr. Jyh-Ping Chen

E-Mail Website
Guest Editor
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan
Interests: drug delivery; tissue engineering; nanobiotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, several nanomaterials have appeared as valuable tools for clinical applications in the areas of drug delivery, diagnosis, bioimaging, and biosensing. Among them, carbon-based nanomaterials have gained importance in biomedicine with their unique physio-chemical properties, excellent optical properties, and high mechanical strength. These nanomaterials not only allow the diagnosis and detection at the molecular scale, but also provide specificity and sensitivity in drug delivery and bioimaging. I am pleased to invite you to submit articles discussing the use of carbon-based nanomaterials (carbon nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) alone, or the combination of them with functionalized molecules (drugs, natural compounds, biomolecules, polymers, metal nanoparticles, etc.), for application in drug delivery, as a sensing material and in theranostics. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Carbon nanomaterials;
  • Drug delivery;
  • Bioimaging;
  • Biosensing;
  • Cancer therapy.

I look forward to receiving your contributions.

Prof. Dr. Jyh-Ping Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Nanotheranostics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon nanotubes
  • graphene
  • graphene oxide
  • carbon quantum dots
  • nanodiamond
  • cancer therapy
  • theranostics
  • biosensing
  • drug delivery

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Published Papers (3 papers)

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Research

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16 pages, 3972 KiB  
Article
Graphene Oxide Chemical Refining Screening to Improve Blood Compatibility of Graphene-Based Nanomaterials
by Fabio Pieretti, Alessandro Moretto, Emanuele Papini and Regina Tavano
J. Nanotheranostics 2024, 5(1), 13-28; https://doi.org/10.3390/jnt5010002 - 20 Feb 2024
Cited by 1 | Viewed by 2169
Abstract
Graphene oxide (GO) nanoparticles, due to their favorable water solubility, compared to graphene (GA), are a hot research topic in biomedical and pharmaceutical research. However, GO clinical translation may be complicated by its high surface/volume ratio enhancing the interaction with human blood components. [...] Read more.
Graphene oxide (GO) nanoparticles, due to their favorable water solubility, compared to graphene (GA), are a hot research topic in biomedical and pharmaceutical research. However, GO clinical translation may be complicated by its high surface/volume ratio enhancing the interaction with human blood components. In fact, GO’s bi-dimensional nature and strong negative charge may lead to severe biological effects, such as thrombogenicity and immune cell activation. This study explores the impact of further GO surface chemical modulation on major adverse effects: blood plasma coagulation and hemolysis. To this aim, we refined GO nanoparticles by fine-tuned reduction chemistry, esterification and introduction of negative or positive charges. With this approach, we were able to mitigate plasma coagulation and hemolysis at variable degrees and to identify GO derivatives with improved biocompatibility. This opens the door to the progress of graphene-based nanotheranostic applications. Full article
(This article belongs to the Special Issue Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment)
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Review

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34 pages, 3131 KiB  
Review
Advanced Nanoparticles in Combating Antibiotic Resistance: Current Innovations and Future Directions
by Dana Mohammed AlQurashi, Tayf Fahad AlQurashi, Raneia Idrees Alam, Sumera Shaikh and Mariam Abdulaziz M. Tarkistani
J. Nanotheranostics 2025, 6(2), 9; https://doi.org/10.3390/jnt6020009 - 23 Mar 2025
Cited by 2 | Viewed by 1444
Abstract
Antibiotic resistance poses a significant global health challenge, undermining the effectiveness of conventional treatments and increasing mortality rates worldwide. Factors such as the overuse and misuse of antibiotics in healthcare and agriculture, along with poor infection control practices, have accelerated the emergence of [...] Read more.
Antibiotic resistance poses a significant global health challenge, undermining the effectiveness of conventional treatments and increasing mortality rates worldwide. Factors such as the overuse and misuse of antibiotics in healthcare and agriculture, along with poor infection control practices, have accelerated the emergence of resistant bacterial strains. The stagnation in the development of new antibiotics, compounded by economic and biological challenges, has necessitated alternative approaches to combat resistant infections. Nanotechnology provides a promising solution using nanoparticles (NPs), which combat bacteria through mechanisms like membrane disruption and reactive oxygen species (ROS) generation. Metal-based nanoparticles such as silver and zinc oxide possess intrinsic antimicrobial properties, while polymer- and carbon-based nanoparticles enhance drug delivery and biofilm penetration. Unlike conventional antibiotics, nanoparticles operate through multi-mechanistic pathways, reducing the likelihood of resistance development and improving treatment efficacy. This review aims to provide an updated, in-depth look at recent advances in nanoparticle research targeting antibiotic resistance, discussing different types of nanoparticles, mechanisms of action, and current challenges and opportunities. By exploring the evolving role of nanotechnology in addressing this crisis, this review intends to highlight the potential for nanoparticles to transform the treatment landscape for resistant bacterial infections and inspire further research into these innovative solutions. Full article
(This article belongs to the Special Issue Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment)
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23 pages, 2221 KiB  
Review
Carbon Dots: New Rising Stars in the Carbon Family for Diagnosis and Biomedical Applications
by Muneeb Ullah, Uzma Azeem Awan, Haider Ali, Abdul Wahab, Shahid Ullah Khan, Muhammad Naeem, Muhammad Ruslin, Apon Zaenal Mustopa and Nurhasni Hasan
J. Nanotheranostics 2025, 6(1), 1; https://doi.org/10.3390/jnt6010001 - 28 Dec 2024
Cited by 4 | Viewed by 2353
Abstract
Carbon dots (CDs) are a class of carbon-based nanomaterials undergoing rapid development with broad potential applications across diverse biomedical fields. These materials are highly attractive for diagnostics, therapeutics, and nanomedicine due to their remarkable optical and physicochemical properties, including photoluminescence, biocompatibility, and aqueous [...] Read more.
Carbon dots (CDs) are a class of carbon-based nanomaterials undergoing rapid development with broad potential applications across diverse biomedical fields. These materials are highly attractive for diagnostics, therapeutics, and nanomedicine due to their remarkable optical and physicochemical properties, including photoluminescence, biocompatibility, and aqueous dispersibility. CDs can be synthesized using various techniques, ranging from top-down to bottom-up approaches. Among these, biogenic synthesis, utilizing natural sources and waste materials, presents an eco-friendly and sustainable alternative. CDs have exhibited considerable promise in diagnostics, especially with bioimaging and biosensing, providing both high sensitivity and precise identification. CDs are presently being investigated in the pharmaceutical sector for their potential applications in cancer and infection treatment, as well as in photodynamic and thermal therapies. The advancement of CD composites, through enhanced functionality and broader application, facilitates novel research in nanomedicine. This article highlights the advantages of CDs, focusing on their structural properties, classification, and versatility in synthesis methods. Furthermore, the safety and toxicity profiles of CDs are critically analyzed. In conclusion, the innocuity, adaptability, and multifunctionality of CDs position them as a cornerstone in the advancement of nanotechnology and biomedical applications. With their broad applicability and promising potential, CDs stand poised to drive significant innovation across diagnostics, therapeutics, and other domains, heralding a new era in nanomedicine and sustainable material development. Full article
(This article belongs to the Special Issue Carbon Nanomaterials as Nano-Theranostic Tools in Disease Treatment)
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