Special Issue "Biomaterial Enhanced Regeneration"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (31 July 2018)
Dr. Dale Feldman
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA
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Interests: biomaterials enhanced regeneration; tissue engineering; wound healing enhancement and characterization; tissue state and wound healing assessment; degradable polymers for drug delivery systems and tissue scaffolds
This particular issue is devoted to the use of biomaterials to stimulate regeneration or a more regenerative response. This can relate to how biomaterials can be used to enhance the regenerative process, or which methods enhance regeneration that benefit from the presence of the biomaterial.
Biomaterial enhanced regeneration falls under the broad heading of tissue engineering: the use of materials (synthetic and natural) usually in conjunction with cells (both native and genetically modified, as well as stem cells) and/or biological response modifiers (growth factors and cytokines, as well as other stimuli which alter cellular activity). The goal is to use these systems to replace tissue and organ functions (biochemical and/or structural).
Biomaterial enhanced regeneration is the branch of tissue engineering as it relates to biomaterials. This is the designing of materials to better deliver and protect the cells (also potentially guide the differentiation of stem cells) and biological response modifiers as well as, in many cases, to better serve as scaffolds to help promote the healing and regenerative process.
Enhancing regeneration covers both moving more toward regeneration, but also speeding up the process. Typically the step that hinders regeneration is angiogenesis (ingrowth of blood supply in a scaffold) to provide short and long-term viability of the tissue, as well as a high enough oxygen level for fibroblasts to produce extracellular matrix (actual tissue ingrowth).
The presence of a scaffold reduces the healing time by reducing the need for the fibroblasts to produce a scaffold along which it can migrate. The scaffold geometry can be optimized for both fibroblast and blood vessel ingrowth. The surface texture and chemistry can also be modified to enhance this response. The scaffold is also important to best utilize biological response modifiers that stimulate mitosis or migration, which would have a limited effect without a scaffold for the cells to attach to and move along.
Dr. Dale Feldman
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Tissue engineering scaffolds
- Cell–matrix interactions
- Cell-seeded scaffolds
- Degradable–regenerative scaffolds
- Angiogenic or vasculogenic scaffolds
- Growth factor drug delivery systems
- Biomimetic extra cellular matrix