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Mesenchymal Stem Cells and Transforming Growth Factor-β3 (TGF-β3) to Enhance the Regenerative Ability of an Albumin Scaffold in Full Thickness Wound Healing

Department of Biomedical Engineering, The University of Alabama at Birmingham, UAB, Birmingham, AL 25294, USA
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J. Funct. Biomater. 2018, 9(4), 65; https://doi.org/10.3390/jfb9040065
Received: 27 September 2018 / Revised: 25 October 2018 / Accepted: 1 November 2018 / Published: 14 November 2018
(This article belongs to the Special Issue Biomaterial Enhanced Regeneration)
Pressure ulcers are one of the most common forms of skin injury, particularly in the spinal cord injured (SCI). Pressure ulcers are difficult to heal in this population requiring at least six months of bed rest. Surgical treatment (grafting) is the fastest recovery time, but it still requires six weeks of bed rest plus significant additional costs and a high recurrence rate. A significant clinical benefit would be obtained by speeding the healing rate of a non-surgical treatment to close to that of surgical treatment (approximately doubling of healing rate). Current non-surgical treatment is mostly inactive wound coverings. The goal of this project was to look at the feasibility of doubling the healing rate of a full-thickness defect using combinations of three treatments, for the first time, each shown to increase healing rate: application of transforming growth factor-β3 (TGF-β3), an albumin based scaffold, and mesenchymal stem cells (MSCs). At one week following surgery, the combined treatment showed the greatest increase in healing rate, particularly for the epithelialization rate. Although the target level of a 100% increase in healing rate over the control was not quite achieved, it is anticipated that the goal would be met with further optimization of the treatment. View Full-Text
Keywords: mesenchymal stem cells; TGF-β3; albumin scaffold; wound healing; pressure ulcers mesenchymal stem cells; TGF-β3; albumin scaffold; wound healing; pressure ulcers
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Feldman, D.S.; McCauley, J.F. Mesenchymal Stem Cells and Transforming Growth Factor-β3 (TGF-β3) to Enhance the Regenerative Ability of an Albumin Scaffold in Full Thickness Wound Healing. J. Funct. Biomater. 2018, 9, 65.

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