Emerging Natural-Polymer-Based Materials for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: 31 March 2027 | Viewed by 431

Editors


E-Mail Website
Guest Editor
CICECO−Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Aveiro, Portugal
Interests: natural polymers; biomaterials; microneedles; skin patches; drug delivery; wound healing; skin applications

E-Mail Website
Guest Editor
IPREM (Institute of Analytical Sciences and Physico-Chemistry for Environment and Materials), University of Pau and the Adour Countries, Pau, France
Interests: natural materials; natural polymers; marine-based biomaterials; bio-inspiration; tissue engineering; 3D scaffolds; hydrogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural polymers are rapidly emerging as key players in the development of next-generation biomedical systems. Proteins and polysaccharides, including collagen, gelatin, silk, chitin, chitosan, alginate, cellulose and hyaluronic acid, possess inherent biocompatibility, biodegradability and structural versatility that make them well-suited for medical use. These polymers can be fabricated into hydrogels, films, fibers, micro- and nanoparticles, three-dimensional scaffolds and microneedle patches, providing a wide range of material architectures with tunable physical and chemical properties that can be tailored for drug delivery, wound healing, tissue engineering and other biomedical applications.

Despite substantial progress in this field, further innovation is needed to expand the functionality and translational potential of natural-polymer-based materials. Key challenges include limited mechanical strength, variable stability, and the need for improved control over drug release and material architecture. Advances in functionalization with bioactive compounds, stimuli-responsive designs and emerging fabrication approaches, including micromolding and 3D bioprinting, are helping to overcome these barriers, opening new avenues for their biomedical use.

This Special Issue aims to highlight recent advances and emerging trends in natural-polymer-based materials for biomedical applications. We invite authors to submit original research articles and reviews addressing innovative fabrication strategies, functional modifications, biological performance, bio-inspiration and novel therapeutic uses of natural-polymer systems. We hope this Special Issue will foster new collaborations and drive progress in natural-polymer-based materials for biomedical applications.

Dr. Ana Cristina Quintans da Silva
Dr. Susana C. M. Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural polymers
  • bioactive compounds
  • biomaterials
  • drug delivery
  • wound healing
  • tissue engineering
  • biomedical applications

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 6736 KB  
Article
Sustainable Carboxymethyl Cellulose-Based Foams via Deep Eutectic Solvent Processing for pH-Responsive Drug Delivery
by Bruno B. Ravanello, Filipe Silva de Matos, Bruna Ramos Navalhas, Luís Pereira and Nalin Seixas
J. Funct. Biomater. 2026, 17(7), 337; https://doi.org/10.3390/jfb17070337 - 12 Jul 2026
Abstract
Carboxymethyl cellulose (CMC)-based materials are widely studied for functional materials and porous platform applications, yet their stability usually requires energy-intensive thermal curing or toxic chemical crosslinkers, which limit process sustainability. In this work, we present a more sustainable approach for the preparation of [...] Read more.
Carboxymethyl cellulose (CMC)-based materials are widely studied for functional materials and porous platform applications, yet their stability usually requires energy-intensive thermal curing or toxic chemical crosslinkers, which limit process sustainability. In this work, we present a more sustainable approach for the preparation of CMC-based foams using deep eutectic solvents (DES) as multifunctional structuring agents. CMC hydrogels were prepared with different DES at room temperature, followed by freeze-drying to obtain foams. Among the tested DES, choline chloride:oxalic acid (1:1) combined with glycerol produced foams with the most favorable properties, including high water uptake (288.24 ± 3.02% after 1 h) and water stability for 28 days. Morphological analysis revealed a homogeneous and interconnected porous network (32.2 ± 13.3 µm), while compression tests demonstrated good mechanical recovery (93.29 ± 3.12% over 10 cycles). Fourier transform infrared spectroscopy suggests interactions between CMC and DES, especially hydrogen bonds. The foams exhibited pH-dependent behavior, with limited resveratrol release under acidic conditions (22.2 ± 4.0% after 24 h), with significant release at pH 7.4 (85.30 ± 5.75%) and total release at pH 13.0. Drug release kinetics suggest a diffusion-controlled mechanism under acidic pH, transitioning to anomalous transport at higher pH values. This study demonstrates that DES can be used to prepare CMC-based foams, providing a more sustainable route to porous materials. Although biological validation is needed to confirm therapeutic safety, this study provides an initial physicochemical basis for using these matrices as tunable and stimuli-responsive porous materials. Full article
(This article belongs to the Special Issue Emerging Natural-Polymer-Based Materials for Biomedical Applications)
Show Figures

Figure 1

Back to TopTop